Taking Risks and Embracing Difference

Thinking about the public speaking classroom as public space provides a generative metaphor as long as critiques of public space, particularly feminist critiques, and critical pedagogy theory are considered. These critiques recognize the importance of encouraging students to engage with the public world in such a way that they see their own paper to effect change. Risk-taking and confronting issues of racism and sexism are integral to this process

Formulation and evaluation of Lornoxicam loaded Lyotropic liquid crystalline gel

GIT irritation is prominent limitation with the use of Non-steroidal anti-inflammatory drugs (NSAID’s). There is rising interest in designing formulations which will deliver the drug at the site of action as topical gels, to avoid GIT irritation and other systemic side effects. Liquid Crystal phase has emerged as a novel material for the preparation of topical drug delivery system. In present study the attempt is made to prepare Lornoxicam loaded lyotropic liquid crystalline gel using glycerol monooleate. Glycerol monooleate is biocompatible, bioadhesive, penetration enhancer and sustain release agent. It also promotes ceramide extraction and enhancement of lipid fluidity in the stratum corneum region of the skin. Five formulation of lornoxicam were prepared and evaluated for parameters like drug content, viscosity, spreadability, Extrudability In-vitro drug release along with in vivo study.  In-Vitro and Ex-Vivo drug release kinetics showed that there was 72.85% and 77.98% drug release within 48 hrs. Skin irritation test suggested that prepared formulation was safe for human use. In-Vivo evaluation of this formulation was done by carrageenan induced rat paw edema anti-inflammatory model. Keywords: Lornoxicam, GMO, Lyotropic liquid crystal, Anti-Inflammatory, Topical drug deliver

CURCUMIN-ZN-ARTEMETHER COMBINATION THERAPY FOR PLASMODIUM BERGHEI INFECTED MICE

Objective: Studies have shown that a new combination therapy with artemisinin derivatives and curcumin is unique, with potential advantages over known Artemisinin Combination Therapy (ACT). The problems of poor solubility, stability and bioavailability of curcumin can be overcome by preparing curcumin metal complex. In present study curcumin-Zn complex was prepared and evaluated for antimalarial activity in combination with artemether.Methods: Curcumin Zn complex was prepared using zinc sulfate. The mice survival and % parasitemia were studied in Plasmodium berghei (P. berghei) infected albino mice treated with curcumin, curcumin-Zn complex and combination of curcumin-Zn with artemether.Results: The mean survival time in mice infected with P. berghei was compared after treatment with curcumin, curcumin-Zn, artemether and combination of curcumin-Zn-artemether. Oral administration of curcumin-Zn-artemether prolonged the survival of P. berghei infected mice. All the mice were treated with Curcumin-Zn (5 mg/day) artemether (1000 µg) survived for more than 40 days and recovered with no detectable parasitemia. Administration of curcumin-Zn artemether combination reduced the parasitemia in mice more effectively compared to that in mice treated with a single drug.Conclusion: In vivo antimalarial activity of curcumin-Zn complex was found superior to curcumin. A single dose of 1000 µg of artemether in combination with curcumin-Zn gives complete protection in P. berghei infected mice. Such suppressive action was superior to that of administration of the single drug at the same dose. This may reduce the chances of drug resistance.Â

Development and Validation of RP-HPLC Method for Estimation of Etizolam in Bulk

The present research work describes a simple, accurate, precise, effective, stability indicating, RP-HPLC method for estimation of Etizolam in there tablet dosage form. A Reverse phase high performance chromatographic method was developed for estimation of Etizolam dosage. The separation was achieved by Cosmosil C18 (250mm×4.6ID, Particle size: 5 micron) and methanol: water in the proportion of 30:70v/v as mobile phase, at a flow rate 0.8ml/min. Detection was carried out at 242nm. For RP-HPLC method results of the validation indicate that the method was linear in the range of 100-600 µg/ml for Etizolam. The % recoveries for Etizolam obtained in the accuracy study were 99.77-99.51% respectively. The LOD for Etizolam were found to be 0.7877µg/ml. LOQ for Etizolam found to be 2.382µ/ml. Developed methods were found to be accurate, precise, rapid and stability indicating for estimation of Etizolam. Keywords: Etizolam, RP-HPLC, tablet dosage for

Formulation Development and Evaluation of Leaf Extract of Ficus benghalensis for Antidiabetic Activity

Herbal products are known for their inherent property i.e. comparatively safe and economic. In present study, leaf extract of ficus benghalensis was evaluated for antidiabetic activity. The aim of the research work was to formulate and evaluate capsule dosage form of ethanolic extract. Leaves of Ficus benghalensis collected from local area of Ahmednagar district and shade dried. Ethanolic, Hydroalcoholic and petroleum ether extracts were prepared using soxhlet apparatus. Extracts were screened for antidiabetic activity using alloxan induced diabetes in rats. Oral glucose tolerance test was measured as parameter to check antidiabetic activity. Ethanolic extract was found most effective among them. Granules were prepared using ethanolic ectract and filled in capsule.  Capsule were evaluated for parameters including uniformity of weight, disintegration time. Keywords: Ficus benghalensis, Ethanolic extract, Antidiabetic activit

Antihistaminic effect of Bauhinia racemosa leaves

Bauhinia racemosa Lam. (Caesalpiniaceae) leaves have been used in the treatment of asthma traditionally and we therefore undertook this study to scientifically validate its benefit in asthma using suitable animal models. Antihistaminic principles are known to be useful in the treatment of asthma; hence, in the present work, the antihistaminic activity of an ethanol extract of B. racemosa (at a dose of 50 mg/kg, i.p.) was assessed using clonidine-induced catalepsy and haloperidol-induced catalepsy in Swiss albino mice. The results showed that the ethanol extract inhibits clonidine-induced catalepsy but there is no effect on haloperidol-induced catalepsy. This suggests that the inhibition is through an antihistaminic action and that there is no role of dopamine. Hence, we concluded that the ethanol extract has significant antihistaminic activity. The polar constituents in the ethanol extract of leaves of B. racemosa may be responsible for the antihistaminic activity and B. racemosa may therefore have a role in the treatment of asthma

Modeling fecal coliform contamination in the Rio Grande

This study examines sources of fecal coliform in Segment 2302 of the Rio Grande, located south of the International Falcon Reservoir in southern Texas. The watershed is unique because the contributing drainage areas lie in Texas and Mexico. Additionally, the watershed is mostly rural, with populated communities known as "colonias." The colonias lack sewered systems and discharge sanitary water directly to the ground surface, thus posing an increased health hazard from coliform bacteria. Monitoring data confirm that Segment 2302 is not safe for contact recreation due to elevated fecal coliform levels. The goal of the study was to simulate the observed exceedences in Segment 2302 and evaluate potential strategies for their elimination. Fecal coliform contributions from ranching and colonia discharges were modeled using the Hydrologic Simulation Program-Fortran (HSPF). Model results indicated that the regulatory 30-day geometric mean fecal coliform concentration of 200 colony forming units (cfu) per 100 milliliters is exceeded approximately three times per year for a total of 30 days. Ongoing initiatives to improve wastewater facilities will reduce this to approximately once per year for 14 days. Best management practices will be necessary to reduce cattle access to streams and eliminate all exceedences. The developed model was limited by the relatively sparse flow and fecal coliform data

Statement to Congress, September 28, 1993 (implications of the proposed North American Free Trade Agreement)

North American Free Trade Agreement ; Laware, John Patrick

Statement to Congress, February 28, 1991 (financial industry reform)

Financial institutions ; Laware, John Patrick ; Bank supervision