Synthesis of regional crust and upper-mantle structure from seismic and gravity data

Available seismic and ground based gravity data are combined to infer the three dimensional crust and upper mantle structure in selected regions. This synthesis and interpretation proceeds from large-scale average models suitable for early comparison with high-altitude satellite potential field data to more detailed delineation of structural boundaries and other variations that may be significant in natural resource assessment. Seismic and ground based gravity data are the primary focal point, but other relevant information (e.g. magnetic field, heat flow, Landsat imagery, geodetic leveling, and natural resources maps) is used to constrain the structure inferred and to assist in defining structural domains and boundaries. The seismic data consists of regional refraction lines, limited reflection coverage, surface wave dispersion, teleseismic P and S wave delay times, anelastic absorption, and regional seismicity patterns. The gravity data base consists of available point gravity determinations for the areas considered

Synthesis of regional crust and upper-mantle structure from seismic and gravity data

Analyses of regional gravity and magnetic patterns, LANDSAT images and geological information revealed two major lineaments crossing western Pennsylvania and parts of surrounding states. These lineaments are inferred to be expressions of fracture zones which penetrare deeply into the crust and possibly the upper mantle. The extensions of the Tyron-Mt. Union and the Pittsburgh-Washington lineaments bound a distinct crustal block (Lake Erie-Maryland block) over 100 km wide and probably more than 600 km in length. Evidence exists for the lateral displacement of this block at least 60 km northwestward during late Precambrian to Lower Ordovician time. Subsequent movements have been mainly vertical with respect to neighboring blocks. A possible crustal block that passes through eastern Kentucky, proposed by a TVA study on tectonics in the southern Appalachians, was also investigated. Finally, the use of regional gravity and magnetic data in identifying major crustal structures beneath western Pennsylvania is discussed

Energy Efficient Engine acoustic supporting technology report

The acoustic development of the Energy Efficient Engine combined testing and analysis using scale model rigs and an integrated Core/Low Spool demonstration engine. The scale model tests show that a cut-on blade/vane ratio fan with a large spacing (S/C = 2.3) is as quiet as a cut-off blade/vane ratio with a tighter spacing (S/C = 1.27). Scale model mixer tests show that separate flow nozzles are the noisiest, conic nozzles the quietest, with forced mixers in between. Based on projections of ICLS data the Energy Efficient Engine (E3) has FAR 36 margins of 3.7 EPNdB at approach, 4.5 EPNdB at full power takeoff, and 7.2 EPNdB at sideline conditions

Influencia del recuento de células somáticas en leche de tanque sobre los parámetros productivos y económicos de las explotaciones de raza Assaf

publishedTomo I . Sección: Sistemas Ganaderos-Economía y Gestión. Sesión: Economía II. Ponencia nº 1

Influencia del tamaño de la explotación sobre los parámetros productivos y económicos de las explotaciones de raza Assaf

publishedTomo I . Sección: Sistemas Ganaderos-Economía y Gestión. Sesión: Economía II. Ponencia nº 1

A multicenter, randomized controlled trial comparing a single intra-articular injection of Gel-200, a new cross-linked formulation of hyaluronic acid, to phosphate buffered saline for treatment of osteoarthritis of the knee

Objective To compare the safety and efficacy of a single intra-articular (IA) injection of a new cross-linked hyaluronic acid product, Gel-200, with phosphate buffered saline (PBS, control) in a multi-center randomized controlled trial in patients with symptomatic osteoarthritis (OA) of the knee. Design Patients were randomized 2:1 to receive a single injection of Gel-200 or PBS, after joint aspiration. The primary measure of effectiveness was Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain subscores by 100-mm Visual Analog Scale (VAS); secondary outcomes included: total WOMAC, physical function, and stiffness subscores; patient and physician global assessments of disease activity, Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT–OARSI) strict responders, as well as safety of Gel-200. Results Of 379 patients randomized, safety was evaluated in 377 and efficacy in 375 (98.9% randomized) in the intent-to-treat population. Effectiveness of Gel-200 by WOMAC pain subscores was statistically significant at week 13 (P = 0.037). Mean improvements from baseline in WOMAC pain subscores consistently favored Gel-200 at each visit. Effectiveness of Gel-200 treatment was statistically significant over weeks 3–13 by WOMAC total score, physical function, and physician global evaluations (P \u3c 0.05). The number of “strict” OMERACT–OARSI responders was statistically significant from weeks 6 to 13 (P = 0.022). Adverse events were not significantly different between treatment groups, including serious adverse events considered related to study treatment. Conclusions This trial demonstrated that a single injection of Gel-200 was well tolerated and relieved pain associated with symptomatic OA of the knee over 13 weeks. Trial registration number ClinicalTrials.gov NTC 00449696

Radiosensitive melanoma cell line with mutation of the gene for ataxia telangiectasia.

The human melanoma cell lines MM96L, A2058 and HT144 were examined for sensitivity to ionizing radiation and UVB radiation. HT144 demonstrated a significant increase in sensitivity to ionizing and UVB radiation compared with the MM96L and A2058 cells. Sensitivity to both agents was associated with susceptibility to apoptosis. Using a protein truncation assay, a mutation for the gene for ataxia telangiectasia (ATM) was identified in HT144 cells. This was confirmed to be a homozygous mutation by subsequent sequencing of the abnormal region. Protein truncation assay of the other two cell lines showed no abnormality. The results suggest that somatic mutation of the A-T gene may be important in determining tumour radiosensitivity

Coastal Upwelling Off The Rias Bajas, Galicia, Northwest Spain I: Hydrographic Studies

Coastal upwelling occurs off the Rias Bajas of Spain between April and October. Superimposed on large-scale upwelling is a mesoscale regime of enhanced upwelling induced by topographic influences. We show that the region surrounding Cape Finisterre has intensified topographically induced upwelling. The rias have a relatively unobstructed connection with the open ocean. Upwelling of high nitrate water on the continental shelf by Ekman transport sets up pressure gradients at the mouth of the rias that induce upwelled water to flow into the rias. Deep water in the rias responds directly to cycles of upwelling and downwelling on the continental shelf