Urinary Nitric Oxide levels are associated with blood pressure, fruit and vegetable intake and total polyphenol excretion in adolescents from the SI! Program

first_pagesettingsOrder Article Reprints Open AccessArticle Urinary Nitric Oxide Levels Are Associated with Blood Pressure, Fruit and Vegetable Intake and Total Polyphenol Excretion in Adolescents from the SI! Program by Sonia L. Ramírez-Garza 1ORCID,Emily P. Laveriano-Santos 1,2ORCID,Camila Arancibia-Riveros 1,Jose C. Carrasco-Jimenez 3,Patricia Bodega 4,5ORCID,Amaya de Cos-Gandoy 4,5ORCID,Mercedes de Miguel 4,5,Gloria Santos-Beneit 4,6,Juan Miguel Fernández-Alvira 5ORCID,Rodrigo Fernández-Jiménez 5,7,8,Jesús Martínez-Gómez 5ORCID,Ramón Estruch 2,9ORCID,Rosa M. Lamuela-Raventós 1,2ORCID andAnna Tresserra-Rimbau 1,2,*ORCID 1 Departament de Nutrició, Ciències de l’Alimentació i Gastronomia, Xarxa d’Innovació Alimentària (XIA), Facultat de Farmàcia i Ciències de l’Alimentació, Institut de Nutrició i Seguretat Alimentària (INSA-UB), Universitat de Barcelona (UB), 08028 Barcelona, Spain 2 Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28220 Madrid, Spain 3 Barcelona Supercomputing Center (BSC), 08034 Barcelona, Spain 4 Foundation for Science, Health and Education (SHE), 08008 Barcelona, Spain 5 Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain 6 The Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA 7 Hospital Universitario Clinico San Carlos, 28040 Madrid, Spain 8 Centro de Investigación Biomédica en Red en Enfermedades CardioVasculares (CIBERCV), 28029 Madrid, Spain 9 Department of Internal Medicine, Hospital Clínic, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona, 08036 Barcelona, Spain * Author to whom correspondence should be addressed. Antioxidants 2022, 11(11), 2140; https://doi.org/10.3390/antiox11112140 Received: 4 October 2022 / Revised: 21 October 2022 / Accepted: 25 October 2022 / Published: 28 October 2022 (This article belongs to the Special Issue Dietary Antioxidants and Cardiovascular Health) Download Browse Figures Review Reports Versions Notes Abstract Nitric oxide (NO) is important to cardiovascular health (CVH), and its bioavailability could be regulated by the antioxidant effect of polyphenols, improving endothelial function and consequently blood pressure (BP). However, scant research has been carried out on NO and CVH correlates in adolescent populations. Therefore, our aim was to investigate the association between NO and the CVH status and other health factors in adolescents. NO, total polyphenol excretion (TPE), anthropometric measurements, BP, blood lipid profile, blood glucose, diet, physical activity, and smoking status were recorded, while CVH score was classified as ideal, intermediate, and poor. Negative associations were observed between NO and body mass index, body fat percentage, BP, and triglycerides; and positive associations between NO and skeletal muscle percentage, HDL-cholesterol, fruit and vegetable intake, and TPE was observed. To capture more complex interactions among different factors, multiple linear regression was performed, obtaining a significant association between NO and fruit and vegetable intake (β = 0.175), TPE (β = 0.225), and systolic BP (β = −0.235). We conclude that urinary NO levels are positively associated with the consumption of fruits and vegetables rich in antioxidants such as polyphenols and negatively associated with systolic BP.Peer Reviewed"Article signat per 14 autors/es:" Sonia L. Ramírez-Garza, Emily P. Laveriano-Santos, Camila Arancibia-Riveros, Jose C. Carrasco-Jimenez, Patricia Bodega, Amaya de Cos-Gandoy, Mercedes de Miguel, Gloria Santos-Beneit, Juan Miguel Fernández-Alvira,Rodrigo Fernández-Jiménez,Jesús Martínez-Gómez, Ramón Estruch, Rosa M. Lamuela-Raventós, and Anna Tresserra-Rimbau"Postprint (published version

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Prevalence and correlates of cardiovascular health among early adolescents enrolled in the SI! Program in Spain: a cross-sectional analysis.

The Instituto de Salud Carlos III-Fondo de Investigacion Sanitaria (PI19/01704) and the European Regional Development Fund/European Social Fund ("A way to make Europe"/"Investing in your future"), the Fundació la Marató de TV3 (369/C/2016), the ‘la Caixa’ Foundation (LCF/PR/CE16/10700001 and LCF/PR/MS19/12220001), the Ministerio de Ciencia e Innovación (AGL2016–75329-R), the Generalitat de Catalunya, and the SHE Foundation. The CNIC is supported by the Instituto de Salud Carlos III (ISCIII), the Ministerio de Ciencia e Innovación, and the Pro CNIC Foundation and is a Severo Ochoa Center of Excellence (SEV-2015-0505).S

Urinary Nitric Oxide Levels Are Associated with Blood Pressure, Fruit and Vegetable Intake and Total Polyphenol Excretion in Adolescents from the SI! Program.

Nitric oxide (NO) is important to cardiovascular health (CVH), and its bioavailability could be regulated by the antioxidant effect of polyphenols, improving endothelial function and consequently blood pressure (BP). However, scant research has been carried out on NO and CVH correlates in adolescent populations. Therefore, our aim was to investigate the association between NO and the CVH status and other health factors in adolescents. NO, total polyphenol excretion (TPE), anthropometric measurements, BP, blood lipid profile, blood glucose, diet, physical activity, and smoking status were recorded, while CVH score was classified as ideal, intermediate, and poor. Negative associations were observed between NO and body mass index, body fat percentage, BP, and triglycerides; and positive associations between NO and skeletal muscle percentage, HDL-cholesterol, fruit and vegetable intake, and TPE was observed. To capture more complex interactions among different factors, multiple linear regression was performed, obtaining a significant association between NO and fruit and vegetable intake (β = 0.175), TPE (β = 0.225), and systolic BP (β = -0.235). We conclude that urinary NO levels are positively associated with the consumption of fruits and vegetables rich in antioxidants such as polyphenols and negatively associated with systolic BP.The SI! Program for Secondary Schools trial was supported by the SHE Foundation, the la Caixa Foundation (LCF/PR/CE16/10700001), the Fundació la Marató de TV3 (grant number 369/C/2016). Support was also provided by the Ministerio de Ciencia, Innovación y Universidades (PID2020-114022RB-I00), CIBEROBN from the Instituto de Salud Carlos III, ISCIII from the Ministerio de Ciencia, Innovación y Universidades (AEI/FEDER, UE), and Generalitat de Catalunya. RF-J is a recipient of grant PI19/01704 funded by the Fondo de Investigación Sanitaria- Instituto de Salud Carlos III (ISCIII) and co-funded by the European Regional Development Fund/European Social Fund a way to make Europe/Investing in your future. The CNIC is supported by the ISCIII, the Ministerio de Ciencia e Innovación (MCIN) and the Pro CNIC Foundation, and is a Severo Ochoa Center of Excellence (grant CEX2020-001041-S funded by MICIN/AEI/10.13039/501100011033). GS-B was the recipient of grant LCF/PR/MS19/12220001 funded by la Caixa Foundation (ID 100010434). AT-R is a Serra Húnter fellow. EL-S was a FI-SDUR (EMC/3345/2020) fellowship from the Generalitat de Catalunya. JM-G was a postgraduate fellow of the Ministerio de Ciencia e Innovación of Spain at the Residencia de Estudiantes (2020–ongoing).S