Silmän etuosauveiittien tunnusomaiset piirteet Pohjois-Suomessa vuosina 2009–2018

Tiivistelmä. Uveiitilla tarkoitetaan silmän sisäistä tulehdusta, jossa tulehdusta on pääosin silmän suonikalvolla. Uveiitit jaetaan tarkemmin eri ryhmiin tulehduksen sijainnin, taudin keston sekä etiologian mukaan. Tässä retrospektiivisessä tutkimuksessa tarkasteltiin silmän etuosan uveiitteja eli iriittejä, jolloin tulehdus rajoittuu silmän etukammioon. Iriittien tiedetään liittyvän useisiin kroonisiin sairauksiin, kuten selkärankareumaan ja Crohnin tautiin. Iriiteillä on havaittu olevan vahva yhteys HLA-B27 kudostyyppiin. Iriittiin voi sairastua esimerkiksi myös silmäleikkauksen tai silmävamman jälkeen. Iriittien hoidon perustana ovat kortikosteroidit ja lisäksi muut immunosuppressiiviset lääkkeet kuten metotreksaatti. Tutkimuksen tarkoituksena oli saada tietoa Pohjois-Suomen iriittipopulaatiosta ja sen tunnusomaisista piirteistä. Tutkimuksen aineisto on Oulun yliopistollisen sairaalan ESKO-potilastietojärjestelmästä, ja siihen kerättiin vuosina 2009–2018 iriittiin sairastuneiden aikuispotilaiden tiedot. Lopulliseen analyysiin saatiin 416 potilasta. Miehiä oli potilaista 50,7 prosenttia ja naisia 49,3 prosenttia. Keskimääräinen sairastumisikä oli noin 40 vuotta. Puolella potilaista iriitti oli idiopaattinen eli taustalla olevaa syytä ei tiedetty. Suurimmalla osalla potilaista (58,4 %) taudinkuva oli krooninen. Tutkimuksessa havaittiin, että yleisin iriitin taustalla oleva perussairaus on selkärankareuma, jota oli 22,4 prosentilla potilaista ja se oli yleisempi miehillä kuin naisilla. Muita havaittuja perussairauksia olivat muun muassa haavainen paksusuolentulehdus, Crohnin tauti, lastenreuma sekä MS-tauti. HLA-B27 positiivisia tautimuotoja oli 70,5 prosenttia, mikä vastaa myös aiemman suomalaisen tutkimuksen tulosta. Suurin osa iriiteistä oli ei-infektiooseja, mutta tutkimuksessa havaittiin myös herpesvirusten ja toksoplasman aiheuttamia reaktioita. Yleisimpänä iriitin aiheuttamana lisäsairautena oli kaihi, jota tavattiin 36,8 prosentilla ja toiseksi yleisin lisäsairaus oli glaukooma, joka todettiin 13,0 prosentilla potilaista. Lähes kaikki tutkimuksen potilaat saivat sidekalvolle annosteltavaa kortikosteroidia iriitin hoitoon. Tutkimuksen tulokset lisäävät merkittävästi tietämystä iriittiä sairastavien potilaiden taudinkuvasta, riskitekijöistä, etiologisista tekijöistä sekä komplikaatioista

Search for supersymmetry in proton-proton collisions at <mml:msqrt>s</mml:msqrt>=13 TeV in events with high-momentum Z bosons and missing transverse momentum

A search for new physics in events with two highly Lorentz-boosted Z bosons and large missing transverse momentum is presented. The analyzed proton-proton collision data, corresponding to an integrated luminosity of 137 fb(-1), were recorded at s = 13 TeV by the CMS experiment at the CERN LHC. The search utilizes the substructure of jets with large radius to identify quark pairs from Z boson decays. Backgrounds from standard model processes are suppressed by requirements on the jet mass and the missing transverse momentum. No significant excess in the event yield is observed beyond the number of background events expected from the standard model. For a simplified supersymmetric model in which the Z bosons arise from the decay of gluinos, an exclusion limit of 1920 GeV on the gluino mass is set at 95% confidence level. This is the first search for beyond-standard-model production of pairs of boosted Z bosons plus large missing transverse momentum.Peer reviewe

Measurements of the W boson rapidity, helicity, double-differential cross sections, and charge asymmetry in pp collisions at root s=13 TeV

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Measurement of the top quark Yukawa coupling from t(t)over-bar kinematic distributions in the dilepton final state in proton-proton collisions at root s=13 TeV

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Measurement of the CP-violating phase phi(s) in the B-s(0) -> J/psi phi(1020) -> mu(+)mu-K+K- channel in proton-proton collisions at root s=13 TeV

The CP-violating weak phase ?s and the decay width difference ??s between the light and heavy B0s mass eigenstates are measured with the CMS detector at the LHC in a sample of 48 500 reconstructed B0s? J/I) d (1020) ?11+11? K+K? events. The measurement is based on a data sample corresponding to an integrated luminosity of 96.4 fb?1, collected in proton-proton collisions at ?s = 13 TeV in 2017?2018. To extract the values of ?s and ??s, a time-dependent and flavor-tagged angular analysis of the 11+11?K+K? final state is performed. The analysis employs a dedicated tagging trigger and a novel opposite-side muon flavor tagger based on machine learning techniques. The measurement yields ?s = ?11 ?50 (stat) ? 10 (syst) mrad and ??s = 0.114 ? 0.014 (stat)? 0.007 (syst) ps?1, in agreement with the standard model predictions. When combined with the previous CMS measurement at ?s = 8 TeV, the following values are obtained: ?s = ?21 ? 44 (stat) ? 10 (syst) mrad, ??s = 0.1032 ? 0.0095 (stat) ? 0.0048 (syst) ps?1, a significant improvement over the 8 TeV result. ? 2021 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY licensePeer reviewe

Search for dark matter produced in association with a leptonically decaying Z boson in proton-proton collisions at root s=13TeV

A Publisher's Erratum to this article was published on 19 April 2021, https://link.springer.com/article/10.1140%2Fepjc%2Fs10052-020-08739-5A search for dark matter particles is performed using events with a Z boson candidate and large missing transverse momentum. The analysis is based on proton-proton collision data at a center-of-mass energy of 13 TeV, collected by the CMS experiment at the LHC in 2016-2018, corresponding to an integrated luminosity of 137 fb(-1). The search uses the decay channels Z -> ee and Z -> mu mu. No significant excess of events is observed over the background expected from the standard model. Limits are set on dark matter particle production in the context of simplified models with vector, axial-vector, scalar, and pseudoscalar mediators, as well as on a two-Higgs-doublet model with an additional pseudoscalar mediator. In addition, limits are provided for spin-dependent and spin-independent scattering cross sections and are compared to those from direct-detection experiments. The results are also interpreted in the context ofmodels of invisible Higgs boson decays, unparticles, and large extra dimensions.Peer reviewe

Development and validation of HERWIG 7 tunes from CMS underlying-event measurements

This paper presents new sets of parameters ("tunes") for the underlying-event model of the herwig 7 event generator. These parameters control the description of multiple-parton interactions (MPI) and colour reconnection in herwig 7, and are obtained from a fit to minimum-bias data collected by the CMS experiment at v s = 0.9, 7, and 13 TeV. The tunes are based on the NNPDF3.1 next-to-nextto-leading-order parton distribution function (PDF) set for the parton shower, and either a leading-order or next-to-nextto-leading-order PDF set for the simulation of MPI and the beam remnants. Predictions utilizing the tunes are produced for event shape observables in electron-positron collisions, and forminimum-bias, inclusive jet, top quark pair, and Zand Wboson events in proton-proton collisions, and are compared with data. Each of the new tunes describes the data at a reasonable level, and the tunes using a leading-order PDF for the simulation of MPI provide the best description of the data.Peer reviewe

Measurement of prompt D-0 and D-0 meson azimuthal anisotropy and search for strong electric fields in PbPb collisions at root S-NN=5.02 TeV

The strong Coulomb field created in ultrarelativistic heavy ion collisions is expected to produce a rapiditydependent difference (Av2) in the second Fourier coefficient of the azimuthal distribution (elliptic flow, v2) between D0 (uc) and D0 (uc) mesons. Motivated by the search for evidence of this field, the CMS detector at the LHC is used to perform the first measurement of Av2. The rapidity-averaged value is found to be (Av2) = 0.001 ? 0.001 (stat)? 0.003 (syst) in PbPb collisions at ?sNN = 5.02 TeV. In addition, the influence of the collision geometry is explored by measuring the D0 and D0mesons v2 and triangular flow coefficient (v3) as functions of rapidity, transverse momentum (pT), and event centrality (a measure of the overlap of the two Pb nuclei). A clear centrality dependence of prompt D0 meson v2 values is observed, while the v3 is largely independent of centrality. These trends are consistent with expectations of flow driven by the initial-state geometry. ? 2021 The Author. Published by Elsevier B.V. This is an open access article under the CC BY licensePeer reviewe

Search for decays of the 125 GeV Higgs boson into a Z boson and a rho or phi meson

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Measurements of the associated production of a W boson and a charm quark in proton–proton collisions at s√=8TeV

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