Total positivity for cominuscule Grassmannians

In this paper we explore the combinatorics of the non-negative part (G/P)+ of a cominuscule Grassmannian. For each such Grassmannian we define Le-diagrams -- certain fillings of generalized Young diagrams which are in bijection with the cells of (G/P)+. In the classical cases, we describe Le-diagrams explicitly in terms of pattern avoidance. We also define a game on diagrams, by which one can reduce an arbitrary diagram to a Le-diagram. We give enumerative results and relate our Le-diagrams to other combinatorial objects. Surprisingly, the totally non-negative cells in the open Schubert cell of the odd and even orthogonal Grassmannians are (essentially) in bijection with preference functions and atomic preference functions respectively.Comment: 39 page

The Effects of Gender and Self Construal on Perception of Racism

When looking into the idea of if one\u27s gender and their self-construal has an effect on how they perceive racism, we hypothesize that women will take a more interdependent self-construal and men will take a more independent self-construal. Based on how they identify, we believe that those in the interdependent condition will perceive more racism and those in the independent condition will perceive less racism

Trends in concussions at Ontario schools prior to and subsequent to the introduction of a concussion policy - an analysis of the Canadian hospitals injury reporting and prevention program from 2009 to 2016

Background: Concussion is a preventable injury that can have long-term health consequences for children and youth. In Ontario, the Policy/Program Memorandum # 158 (PPM) was introduced by the Ministry of Education of Ontario in March 2014. The PPM’s main purpose is to require each school board in the province to create and implement a concussion policy. The purpose of this paper is to examine trends in school-based concussions prior to and subsequent to the introduction of the PPM. Methods: This report examined emergency department (ED) visits in 5 Ontario hospitals that are part of the Canadian Hospitals Injury Reporting and Prevention Program (CHIRPP), and compared trends over time in diagnosed concussions, and suspected concussions identified as “other head injury” in children and youth aged 4–18. Results: From 2009 to 2016 study years, there were 21,094 suspected concussions, including 8934 diagnosed concussions in youth aged 4–18. The average number of diagnosed concussions in the 5 years before the PPM was 89 concussions/month, compared to approximately 117 concussions per month after; a 30% increase in the monthly rate of concussions presenting to the ED. The total number of concussion or head injury-related ED visits remained relatively unchanged but the proportion of diagnosed concussions rose from 31% in 2009 to 53% in 2016. The proportion of diagnosed concussions in females also increased from 38% in 2013 to 46% in 2016. The percent of all diagnosed concussions occurring at schools increased throughout the study reaching almost 50% in 2016 with most injuries taking place at the playground (24%), gymnasium (22%) or sports field (20%). Conclusions: The introduction of the PPM may have contributed to a general increase in concussion awareness and an improvement in concussion identification at the school level in children and youth aged 4–18. Keywords: Concussion, Policy, Emergency department, YouthYork University Librarie

Performance of a quality assurance program for assessing dental health in methamphetamine users.

BackgroundSystematic characterization of the dental consequences of methamphetamine (MA) abuse presupposes a rigorous quality assurance (QA) program to ensure the credibility of the data collected and the scientific integrity and validity of the clinical study. In this report we describe and evaluate the performance of a quality assurance program implemented in a large cross-sectional study of the dental consequences of MA use.MethodsA large community sample of MA users was recruited over a 30 month period during 2011-13 and received comprehensive oral examinations and psychosocial assessments by site examiners based at two large community health centers in Los Angeles. National Health and Nutrition Examination Survey (NHANES) protocols for oral health assessments were utilized to characterize dental disease. Using NHANES oral health quality assurance guidelines, examiner reliability statistics such as Cohen's Kappa coefficients and inter-class correlation coefficients were calculated to assess the magnitude of agreement between the site examiners and a reference examiner to ensure conformance and comparability with NHANES practices.ResultsApproximately 9% (n = 49) of the enrolled 574 MA users received a repeat dental caries and periodontal examination conducted by the reference examiner. There was high concordance between the reference examiner and the site examiners for identification of untreated dental disease (Kappa statistic values: 0.57-0.75, percent agreement 83-88%). For identification of untreated caries on at least 5 surfaces of anterior teeth, the Kappas ranged from 0.77 to 0.87, and percent agreement from 94 to 97%. The intra-class coefficients (ICCs) ranged from 0.87 to 89 for attachment loss across all periodontal sites assessed and the ICCs ranged from 0.79 to 0.81 for pocket depth. For overall gingival recession, the ICCs ranged from 0.88 to 0.91. When Kappa was calculated based on the CDC/AAP case definitions for severe periodontitis, inter-examiner reliability for site examiners was low (Kappa 0.27-0.67).ConclusionOverall, the quality assurance program confirmed the procedural adherence of the quality of the data collected on the distribution of dental caries and periodontal disease in MA-users. Examiner concordance was higher for dental caries but lower for specific periodontal assessments

California Drought Outlooks Based on Climate Change Models’ Effects on Water Availability

Future streamflow in California is evaluated based on eight climate projections models and the effects on water availability. The unimpaired projected streamflow for eleven California rivers, collected from Cal-Adapt, are compared with unimpaired historical flows (1950–2015) using eight climate model projections (2020–2099) identified as representative as possible future scenarios; Warm Dry RCP 4.5, Average RCP 4.5, Cool Wet RCP 4.5, Other RCP 4.5, Warm Dry RCP 8.5, Average RCP 8.5, Cool Wet RCP 8.5, and Other RCP 8.5. Projected drought deficits (or magnitudes), durations, and intensities are statistically tested against historical values to determine significance of differences between past streamflow and future streamflow. The models show significant differences between historical and projected streamflow with all three drought categories (deficit, duration, intensity), using difference in means t-tests. Warm Dry and Other simulations are projected to have larger droughts (2–3 times larger) than the historical record. Average and Cool Wet simulations are projected to have fewer droughts than the historical period. Results are consistent for 4.5 and 8.5 RCP scenarios that represent two different greenhouse gas emission levels. Potential impacts of such streamflow variations are discussed

Pancreatic Enzyme Dosing and Gastrointestinal Symptoms in Children with Cystic Fibrosis

The aim of this study is to determine if higher than the recommended dosing for pancreatic enzyme replacement therapy (PERT) improves GI symptoms in children with Cystic fibrosis. Children with CF and exocrine pancreatic insufficiency (EPI) were categorized into two groups based on PERT dosing: less than 10,000 lipase units/kg/day, or greater than 10,000 lipase units/kg/day. Methods: 142 pediatric CF patients from the Nebraska Regional CF Center were included in the retrospective evaluation. Patients were split into two different groups based on their pancreatic enzyme dosing. Group 1 was greater than 10,000 lipase units/kg/day of enzymes, and group 2 was less than 10,000 lipase units/kg/day. Results: The p-value of the results was 0.5992, meaning that there was no statistical difference between the GI symptoms for those who take less or greater than 10,000 lipase units/kg/day of enzymes. The group that takes greater than 10,000 lipase units/kg/day are 1.194 times more likely to experience GI symptoms compared to the group with less than 10,000 lipase units per day. Conclusion: Based on the analysis that was completed on the data, there is no statistical significance between those that take greater or less than 10,000 lipase units/kg/day of pancreatic enzymes.https://digitalcommons.unmc.edu/surp2021/1018/thumbnail.jp

Sensitization of renal carcinoma cells to TRAIL-induced apoptosis by rocaglamide and analogs

Rocaglamide has been reported to sensitize several cell types to TRAIL-induced apoptosis. In recent years, advances in synthetic techniques have led to generation of novel rocaglamide analogs. However, these have not been extensively analyzed as TRAIL sensitizers, particularly in TRAIL-resistant renal cell carcinoma cells. Evaluation of rocaglamide and analogs identified 29 compounds that are able to sensitize TRAIL-resistant ACHN cells to TRAIL-induced, caspase-dependent apoptosis with sub-µM potency which correlated with their potency as protein synthesis inhibitors and with loss of cFLIP protein in the same cells. Rocaglamide alone induced cell cycle arrest, but not apoptosis. Rocaglates averaged 4–5-fold higher potency as TRAIL sensitizers than as protein synthesis inhibitors suggesting a potential window for maximizing TRAIL sensitization while minimizing effects of general protein synthesis inhibition. A wide range of other rocaglate effects (e.g. on JNK or RAF-MEK-ERK signaling, death receptor levels, ROS, ER stress, eIF4E phosphorylation) were assessed, but did not contribute to TRAIL sensitization. Other than a rapid loss of MCL-1, rocaglates had minimal effects on mitochondrial apoptotic pathway proteins. The identification of structurally diverse/mechanistically similar TRAIL sensitizing rocaglates provides insights into both rocaglate structure and function and potential further development for use in RCC-directed combination therapy.This project has been funded in whole or in part with Federal funds from the National Cancer Institute, National Institutes of Health, under Contract No. HHSN261200800001E. The content of this publication does not necessarily reflect the views or policies of the Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the U.S. Government. This research was supported [in part] by the Intramural Research Program of NIH, Frederick. National Lab, Center for Cancer Research. Research performed at Boston University was supported in part by NIH R35 GM118173. Work at the BU-CMD is supported by R24 GM111625. (HHSN261200800001E - National Cancer Institute, National Institutes of Health; Intramural Research Program of NIH, Frederick. National Lab, Center for Cancer Research; R35 GM118173 - NIH; R24 GM111625)Published versio