The cultural divide in Europe: migration, multiculturalism, and political trust

One of the defining features of modern states is their incorporation of notions of political and social community based on shared language, history, and myths. However, large numbers of citizens in modern states have come to believe their national communities are under threat from several modern forces, including immigration. Using the European Social Survey (2002-2009), this paper explores the extent to which perceived threats posed by large-scale immigration undermine national political communities by reducing trust in national politicians and political institutions. The findings indicate that even after controlling for other predictors of trust in the political system, concerns about the effect of immigration on the national community have an impact on trust in politics. Moreover, having a lengthy post-war history with mass immigration mediates this effect, while the potentially mobilizing effects of far-right parties on the relationship between concern about immigration and political distrust are somewhat limited

Explaining Opposition to Turkish Membership of the EU

This article examines EU citizen attitudes to Turkey's bid to join the EU. The key theoretical constructs investigated to explain opposition to Turkey's EU membership are related to rational economic self-interest and group-level interests and concerns. The findings indicate that the former are irrelevant for distinguishing between opponents and supporters of Turkey's candidacy, while the latter do provide fairly powerful explanations for opposition to Turkish EU membership. However, because these factors do not completely explain overall levels of hostility to Turkey's candidacy, context is also introduced, particularly the threatening context provided by Turkish migration. The findings indicate that migration from Turkey to some of the EU member states has combined with feelings of group protectiveness to produce widespread animosity to Turkey's entry into the EU

Special considerations in the treatment of patients with bipolar disorder and medical co-morbidities

BACKGROUND: The pharmacological treatment of bipolar disorder has dramatically improved with multiple classes of agents being used as mood-stabilizers, including lithium, anticonvulsants, and atypical antipsychotics. However, the use of these medications is not without risk, particularly when a patient with bipolar disorder also has comorbid medical illness. As the physician who likely has the most contact with patients with bipolar disorder, psychiatrists must have a high index of suspicion for medical illness, as well as a basic knowledge of the risks associated with the use of medications in this patient population. METHODS: A review of the literature was conducted and papers addressing this topic were selected by the authors. RESULTS AND DISCUSSION: Common medical comorbidities and treatment-emergent illnesses, including obesity, diabetes mellitus, dyslipidemia, cardiac disease, hepatic disease, renal disease, pulmonary disease and cancer are reviewed with respect to concomitant use of mood stabilizers. Guidance to clinicians regarding effective monitoring and treatment is offered. CONCLUSIONS: Mood-stabilizing medications are necessary in treating patients with bipolar disorder and often must be used in the face of medical illness. Their safe use is possible, but requires increased vigilance in monitoring for treatment-emergent illnesses and effects on comorbid medical illness

Immigration and trust in politics in Britain

This paper argues that a previously overlooked explanation for varying individual-levels of political trust is concern about immigration. Focusing on the case of Britain, where levels of opposition to immigration have remained high since the 1960s and yet the implications of such opposition are still unclear, this paper examines the effect of concern about immigration on political trust. Using the pre- and post-election panel component of the 2005 British Election Study and the 2002-3 European Social Survey, we illustrate that after controlling for a wide range of other predictors of trust in politics, concerns about the impact of immigration significantly affect political trust. In addition, in 2005 the perception that government had not handled the issue of immigration effectively also significantly affected political trust, with both linear and interactive effects

Immigration and trust in politics in Britain

This paper argues that a previously overlooked explanation for varying individual-levels of political trust is concern about immigration. Focusing on the case of Britain, where levels of opposition to immigration have remained high since the 1960s and yet the implications of such opposition are still unclear, this paper examines the effect of concern about immigration on political trust. Using the pre- and post-election panel component of the 2005 British Election Study and the 2002-3 European Social Survey, we illustrate that after controlling for a wide range of other predictors of trust in politics, concerns about the impact of immigration significantly affect political trust. In addition, in 2005 the perception that government had not handled the issue of immigration effectively also significantly affected political trust, with both linear and interactive effects

Targeted SERS nanosensors measure physicochemical gradients and free energy changes in live 3D tumor spheroids.

Use of multicellular tumor spheroids (MTS) to investigate therapies has gained impetus because they have potential to mimic factors including zonation, hypoxia and drug-resistance. However, analysis remains difficult and often destroys 3D integrity. Here we report an optical technique using targeted nanosensors that allows in situ 3D mapping of redox potential gradients whilst retaining MTS morphology and function. The magnitude of the redox potential gradient can be quantified as a free energy difference (ΔG) and used as a measurement of MTS viability. We found that by delivering different doses of radiotherapy to MTS we could correlate loss of ΔG with increasing therapeutic dose. In addition, we found that resistance to drug therapy was indicated by an increase in ΔG. This robust and reproducible technique allows interrogation of an in vitro tumor-model's bioenergetic response to therapy, indicating its potential as a tool for therapy development.Leverhulme Trust (Grant ID: RPG-2012-680), Jamie King Cancer Research FundThis is the final version of the article. It first appeared from the Royal Society of Chemistry via http://dx.doi.org/10.1039/C6NR06031

Analysis of the outer retinal bands in ABCA4 and PRPH2-associated retinopathy using OCT

Purpose: To evaluate the outer retinal bands using OCT in ABCA4- and PRPH2-associated retinopathy and develop a novel imaging biomarker to differentiate between these 2 genotypes. Design: Multicenter case-control study. Participants: Patients with a clinical and genetic diagnosis of ABCA4- or PRPH2-associated retinopathy and an age-matched control group. Methods: Macular OCT was used to measure the thickness of the outer retinal bands 2 and 4 by 2 independent examiners at 4 retinal loci. Main Outcome Measures: Outcome measures included the thicknesses of band 2, band 4, and the band 2/band 4 ratio. Linear mixed modeling was used to make comparisons across the 3 groups. Receiver operating characteristic (ROC) analysis determined the optimal cutoff for the band 2/band 4 ratio to distinguish PRPH2- from ABCA4-associated retinopathy. Results: We included 45 patients with ABCA4 variants, 45 patients with PRPH2 variants, and 45 healthy controls. Band 2 was significantly thicker in patients with PRPH2 compared with ABCA4 (21.4 vs. 15.9 m, P \u3c 0.001) variants, whereas band 4 was thicker in patients with ABCA4 variants than those with PRPH2 variants (27.5 vs. 21.7 m, P \u3c 0.001). Similarly, the band 2/band 4 ratio was significantly different (1.0 vs. 0.6 for PRPH2 vs. ABCA4, P \u3c 0.001). The area under the ROC curve was 0.87 for either band 2 ( \u3e 18.58 m) or band 4 ( \u3c 26.17 μm) alone and 0.99 (95% confidence interval: 0.97–0.99) for the band 2/band 4 ratio with a cutoff threshold of 0.79, providing 100% specificity. Conclusions: We report an altered outer retinal band profile whereby the band 2/band 4 ratio was able to discriminate between PRPH2- and ABCA4-associated retinopathy. This may have future clinic utility in predicting the genotype and provide further insight into the anatomic correlate of band 2. Financial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article

Global change effects on plant communities are magnified by time and the number of global change factors imposed

Global change drivers (GCDs) are expected to alter community structure and consequently, the services that ecosystems provide. Yet, few experimental investigations have examined effects of GCDs on plant community structure across multiple ecosystem types, and those that do exist present conflicting patterns. In an unprecedented global synthesis of over 100 experiments that manipulated factors linked to GCDs, we show that herbaceous plant community responses depend on experimental manipulation length and number of factors manipulated. We found that plant communities are fairly resistant to experimentally manipulated GCDs in the short term (<10 y). In contrast, long-term (≥10 y) experiments show increasing community divergence of treatments from control conditions. Surprisingly, these community responses occurred with similar frequency across the GCD types manipulated in our database. However, community responses were more common when 3 or more GCDs were simultaneously manipulated, suggesting the emergence of additive or synergistic effects of multiple drivers, particularly over long time periods. In half of the cases, GCD manipulations caused a difference in community composition without a corresponding species richness difference, indicating that species reordering or replacement is an important mechanism of community responses to GCDs and should be given greater consideration when examining consequences of GCDs for the biodiversity–ecosystem function relationship. Human activities are currently driving unparalleled global changes worldwide. Our analyses provide the most comprehensive evidence to date that these human activities may have widespread impacts on plant community composition globally, which will increase in frequency over time and be greater in areas where communities face multiple GCDs simultaneously