Effects of Restraint Stress and Allopregnanolone Inhibition on Amphetamine Locomotor Sensitivity

The chronic, recurring nature of addiction remains a worldwide problem. Even after apparently successful clinical treatment and long term abstinence, individuals may still relapse many months or years later. Although many individual differences exist among substance abusers, relapse tends to occur during periods of high stress (Sinha et al., 2006). Behavioral training and therapy can help cope during these high stress times, but pharmacological interventions have not been shown to be effective (Ross & Peselow, 2009). Although some therapeutic options decrease relapse rates, more effective treatments for relapse need further consideration. The effect of stress on use of and relapse to drugs of abuse likely stems from coupled stress and reward circuits in the brain. Stress leads to increased release of stress-related hormones including 3α, 5α tetrahydroprogesterone or, allopregnanolone (Purdy et al., 1991). Allopregnanolone is a neurosteroid tied to several brain circuits involved with stress and reward. Elevated levels of this neurosteroid occur throughout the mammalian brain and periphery after cocaine administration, and rats show enhanced dopamine release in the nucleus accumbens after an injection of finasteride, which inhibits the enzymes (5-α reductase I) responsible for allopregnanolone synthesis (Dazzi et al., 2002). Finally, acutely stressed rats exhibit increased dopamine release in the prefrontal cortex after an injection of finasteride, further indicating allopregnanolone’s involvement with brain reward systems (Devoto, 2012). Based on this information, we hypothesized that administration of finasteride would result in increased stress induced amphetamine locomotor sensitization

How to Sustain Excellence: Reigniting Your Mojo

Sustainability is a widely recognized and researched component for continued positive outcomes of a school or district’s implementation of Positive Behavioral Interventions and Supports (PBIS). Many schools and districts find that around two years after initial implementation, sometimes even with past positive outcomes, implementation efforts can lose effectiveness and teams lose momentum. Data may show that schools are implementing with poor fidelity or focusing on only limited elements of the PBIS framework. Drawing on the body of published research, knowledge and tools, two large school districts in the metropolitan Atlanta area collaborated in their efforts to reignite the commitment and efforts of their district and school teams. With a large number of schools at varying levels of implementation it can be challenging to not only identify the diverse causes of stagnation, but to analyze the systemic factors that may be contributing to diminished commitment. A review of the research on sustainability (McIntosh et al., 2014) and use of available PBIS assessment tools can empower districts to differentiate their support to schools and provide schools strategies to reinvigorate their school’s commitment while increasing family and community participation. In this presentation we will discuss our experiences with a variety of causes and some practical solutions to help maintain the momentum of the initial success

State of Nebraska Digital Equity Plan: Understanding the Digital Equity Needs of Covered Populations in Nebraska

According to 2021 estimates from the U.S. Census Bureau’s American Community Survey, 7% of Nebraska households do not have access to a computer and 6% of Nebraska households have access to a computer but no internet. Although recent efforts suggest there is momentum and government action at both the federal and state levels to address lack of broadband (Hammel, 2023; Newman, 2023), this still leaves a considerable number of Nebraskans without access to reliable broadband in the meantime. Furthermore, broadband access is moot if Nebraskans do not have access or cannot afford technology and the cost of internet in the first place. The purpose of this report is to take a deeper look at specific covered populations in Nebraska who are more likely to be without affordable, reliable technology access and, therefore, are disproportionally impacted by the digital divide. The research team, representing the University of Nebraska at Omaha Center for Public Affairs Research and Department of Gerontology, was approached by the Nebraska Information Technology Commission to conduct focus groups with covered populations. Key findings from focus groups are shared. Findings indicate that access to technology and internet is not only vital for all Nebraskans but is also costprohibitive for already marginalized populations. Moving forward, these findings will inform the creation of a state digital equity plan for Nebraska

Supporting users in their pursuit and use of our e-books: Perspectives from one large academic library

More e-books in a library’s collection means major changes in the individual user’s experience. At the University of Minnesota Libraries, we are taking several steps to support our users as they expand their worlds to include e-books. After an initial trial 2 years ago, we have moved into the arena of demand-driven acquisition for e-books by displaying selected records in MNCAT, our catalog, and allowing users to trigger purchases after a prescribed set of views. Purchase and use records are closely monitored. To assess whether we should make changes to MNCAT or take other steps that could enhance a user’s ability to locate books in e-format, we have reviewed the literature and investigated what other large academic libraries have done. In order to both serve users directly and help library staff provide quick and accurate information, we have developed a Web site that provides details about several of the large e-book packages to which we subscribe. It covers features such as number of simultaneous users, compatibility with various e-readers, and steps for printing and downloading, if they are available. Lastly, the librarians who are liaisons to the College of Education and Human Development are working with the College’s iPad initiative, which provides a device to each incoming undergraduate student. We are beginning to develop materials and strategies that complement the College’s efforts to assist instructors and students in the most effective use of e-books and other library materials on their iPads.To access the full presentation for this session, click on the Download button located to the right

Geographic distribution and genetic diversity of the Ehrlichia sp. from Panola Mountain in Amblyomma americanum

Background: A novel Ehrlichia, closely related to Ehrlichia ruminantium, was recently discovered from Panola Mountain State Park, GA, USA. We conducted a study to determine if this agent was recently introduced into the United States. Methods: We developed a sensitive PCR assay based on the conserved gltA (citrate synthase) gene and tested DNA samples extracted from 1964 field-collected and 1835 human-biting Amblyomma americanum from 23 eastern states of the USA. Results: The novel agent was detected in 36 ticks collected from 10 states between 1998 and 2006. Infected ticks were collected both from vegetation (n = 14, 0.7%) and from humans (n = 22, 1.2%). Fragments of the conserved gltA gene and the variable map1 gene were sequenced from positive samples. Two distinct clades, with 10.5% nucleic acid divergence over the 730 bp map1 sequence, were identified. Conclusion: These data suggest that the Panola Mountain Ehrlichia was not recently introduced to the United States; this agent has an extensive distribution throughout the range of its tick vector, has been present in some locations for several years, and displays genetic variability. Furthermore, people in several states were exposed to this agent through the bite of infected ticks, underscoring the potential public health risk of this emerging ehrlichiosis

The Concise Guide to PHARMACOLOGY 2023/24:Nuclear hormone receptors

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16179. Nuclear hormone receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.</p

The Concise Guide to PHARMACOLOGY 2023/24:Nuclear hormone receptors

The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/10.1111/bph.16179. Nuclear hormone receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein-coupled receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.</p

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22:Nuclear hormone receptors

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point‐in‐time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15540. Nuclear hormone receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein‐coupled receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid‐2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC‐IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate