49 research outputs found
Spatial Distribution of Economic Activities in Local Labour Market Areas: the Case of Italy
In recent years, a large number of studies investigated the spatial distribution of economic activities in Western Europe by means of various measures of geographical concentration. The fundamental problem with the indices currently used in the literature is that they do not take explicitly into account the spatial structure of the data, and as a result the same degree of concentration is compatible with very different localization schemes. In the present work we present an analysis which combines the information provided by the standard measure of concentration of Ellison and Glaeser together with the measure of spatial correlation introduced by Moran. The problem known in geography as MAUP is here addressed by considering both administrative and functional regions in the empirical analyses. Data on employment and plant size for the years 1991 and 2001 are used to identify sectoral location patterns in Italy and The Netherlands within the manufacturing and service sectors.
The relationship between Regional Growth and Regional Inequality in EU and transition countries - a Spatial Econometric Approach
Is inequality good or bad for growth? This issue, with its important political bearings, has attracted much attention in the past in the economic literature. Starting from the seminal work of Kuznet (1955), in the literature there is some empirical evidence that economies with unequal distribution of income grow faster than those with an even income distribution. Such a belief has been heavily criticised by recent studies, and some contrasting views, supported by empirical evidence, were expressed e.g. by Aghion et al. (1999). Barro (2000) also argues in this direction, but empirically found little overall relation between income inequality on one side and growth rates and investment on the other. The debate, thus, seems still open. In our analysis we aim at investigating whether space and spatial relationships play a significant role in the specification of the relationship between regional inequality and regional growth. In particular, we analyse the case of European Regions, including the transition countries that recently joined the EU. In the empirical analysis, we make use of spatial panel data models, as they let us consider both time-invariant country specific fixed-effects and spatial dependence. By controlling for omitted variables and for spatial dependence we can be more confident that the estimated coefficient measures exactly the impact of inequality on the growth process
The Spatial Distribution of Economic Activities in Italy
Existing indices measuring the spatial distribution of economic activity such as the Krugman Specialisation Index, the Hirschmann-Herfindahl index and the Ellison-Glaeser index typically do not take into account the spatial structure of the data. In this paper, we first consider traditional measures of geographical concentration, and subsequently extend the analysis to take spatial dependence into account. Using data for Italy for the years 1991 and 2001, we apply exploratory spatial data analysis to identify sectoral location patterns in both the manufacturing industry as well as in services. We find that large differences prevail in the geographical concentration of production across sectors. The results of the exploratory spatial data analysis reveal the existence of well- defined clusters of economic activities
Spatial Distribution of Economic Activities in Local Labour Market Areas: the Case of Italy
In recent years, a large number of studies investigated the spatial distribution of economic activities in Western Europe by means of various measures of geographical concentration. The fundamental problem with the indices currently used in the literature is that they do not take explicitly into account the spatial structure of the data, and as a result the same degree of concentration is compatible with very different localization schemes. In the present work we present an analysis which combines the information provided by the standard measure of concentration of Ellison and Glaeser together with the measure of spatial correlation introduced by Moran. The problem known in geography as MAUP is here addressed by considering both administrative and functional regions in the empirical analyses. Data on employment and plant size for the years 1991 and 2001 are used to identify sectoral location patterns in Italy and The Netherlands within the manufacturing and service sectors
Communicating corporate social responsibility to involve stakeholders. The case of employer branding for university students
La responsabilitĂ sociale d'impresa (o Corporate Social Responsibility, CSR) Ăš uno strumento efficace di marketing e la sua efficacia Ăš mediata dalla modalitĂ con cui le aziende comunicano le proprie attivitĂ di CSR agli stakeholder. La ricerca si propone di valutare l'effetto di cinque strategie di comunicazione della CSR, ordinate secondo un livello crescente di coinvolgimento degli stakeholder, sull'Employer Branding (EB) di un'azienda ipotetica. Attraverso la distribuzione di cinque varianti di un opuscolo, lâazienda Ăš stata presentata a due campioni di studenti universitari (n=167; n=112) in cinque diversi scenari comunicativi della CSR. Ă stato somministrato un questionario con scale che misurano lâattrattivitĂ dell'azienda, il prestigio percepito dell'azienda, la disponibilitĂ dei soggetti a entrare in contatto con l'azienda e lâimpegno prospettico sul lavoro. Ă stata anche indagata la percezione della brand personality e della comunicazione della CSR. Le analisi confermano che tutti e cinque gli scenari sono caratterizzati da alti livelli delle dimensioni dellâEB, perĂČ lo specifico dialogo di CSR adottato puĂČ generare differenti percezioni della brand personality dell'azienda.Corporate Social Responsibility (CRS) is an effective marketing lever, and its effectiveness is mediated by the strategies companies use to communicate their CRS activities to stakeholders. The present research aims at assessing the effect of five CSR communicative strategies, ranked according to an increasing involvement level of stakeholders, on a fictional companyâs Employer Branding (EB). The company was presented to two samples of university students (n=167; n=112) via the administration of five different versions of a brochure, corresponding to five different communicative scenarios of CSR. A self-report questionnaire was administrated, with scales measuring the companyâs attractiveness, perceived prestige, intention to contact the company, and prospective engagement, as well as the companyâs perceived brand personality and CSR communication. Analyses report high levels of the EB dimensions in all five communicative scenarios, which however produce different perceptions of the companyâs brand personality
European university funding and financial autonomy. A study on the degree of diversification of university budget and the share of competitive funding
The main objective of this report is to investigate the structure of the budget in a sample of research-active European universities and to analyse to what extent the level of financial autonomy effects the diversification of their budget and the amount of competitive funding they receive.
The study covers 200 research-active universities from 33 European Research Area (ERA) countries (27 Member States and Croatia, Iceland, Israel, Norway, Switzerland and Turkey) within the framework of the 'European Observatory of Research-Active Universities and National Public Research Funding Agencies' (UniObs). The criteria followed to select the list of universities in the sample are based on research performance and country representativeness.
The main findings of the study are as follows:
ÂżLooking at the general budget, 70 % of the total university income comes from government allocations. Sources from private companies represent about 6 %, around 3 % comes from non-profit sectors and approximately 2 % is from abroad. The remaining 19 % belongs to a residual category 'Other'.
ÂżConsidering only public funding coming from government (national and regional) we observe that, on average, about 20 % is assigned on a competitive basis, with UK institutions and, in general, technological universities having the highest shares of competitive funds.
ÂżWe observe large within-country variability in the shares of government competitive funds, which could be attributed to the strategic behaviour of single institutions in acquiring funds or to their ability to compete successfully against other institutions. Examples of these are the University of Cambridge in the UK, the University of Karlsruhe in Germany, the University of Florence in Italy, and the universities of Leiden and Wageningen in the Netherlands.
ÂżMost institutions with highly diversified budgets are located in the UK.
ÂżUniversity research budgets vary considerably between institutions. Research funds coming from regional authorities are considered important for institutions operating in countries with a more decentralised government structure such as Belgium, Germany or Spain.
ÂżInstitutions that declare to be completely autonomous are the ones that have the most diversified budget.
ÂżThe share of competitive-based government funds increases with increasing levels of institutional financial autonomy.
ÂżNational or institutional settings which do not allow universities to act in a fully financially autonomous way appear to be less likely to produce a real change.JRC.DDG.J.3-Knowledge for Growt
Report on the Quality of life in European Cities, 2020
This report presents the results from the fifth survey on quality of life in European cities. It covers 83 cities in the EU, the EFTA countries, the UK, the Western Balkans and Turkey. It reveals in which cities, people are satisfied with a range of public services and amenities. It captures peopleâ s experience, for example, with crime, and their feelings, for example, if they feel safe walking alone at night. These results are important for policy makers at the European, national and city level. It They can help to identify priorities for Cohesion Policy investments and can support the policy exchanges as part of the Urban Agenda for the EU
Report on the Quality of life in European cities, 2023
This report presents the main findings from the sixth survey on the quality of life of European cities. The survey covers 83 cities across the EU, European Free Trade Association (EFTA) countries, the United Kingdom, the western Balkans and TuÌrkiye and allows for comparison with the last edition of the survey, conducted in 2019. The COVID-19 pandemic, which emerged in Europe at the beginning of 2020, and Russianâs unjustified invasion of Ukraine may have had an impact on the way people perceive quality of life in the city where they live. These crises have placed immense stress on urban infrastructure, healthcare systems, economies and social dynamics. Lockdowns, restrictions and reduced tourism hit the residents and economies of European cities hard. The ongoing Russian war of aggression against Ukraine has led to the displacement of many individuals, both internally and externally. European cities became destinations for these displaced people, adding pressure on resources and services. The results of the 2023 exercise show that overall satisfaction across European cities has declined compared to the satisfaction levels recorded in 2019, but remains high, with almost nine out of ten people reporting to be satisfied with living in their city. Amid the overall decline, results confirm what was already observed in 2019, that is significant improvements in perceived quality of life in cities in eastern Member States
Anomalous Kv 7 channel activity in human malignant hyperthermia syndrome unmasks a key role for H2 S and persulfidation in skeletal muscle.
BACKGROUND AND PURPOSE: Human malignant hyperthermia (MH) syndrome is induced by
volatile anaesthetics and involves increased levels of cystathionine ÎČ-synthase
(CBS)-derived H2 S within skeletal muscle. This increase contributes to skeletal
muscle hypercontractility. Kv 7 channels, expressed in skeletal muscle, may be a
molecular target for H2 S. Here, we have investigated the role of Kv 7 channels
in MH.
EXPERIMENTAL APPROACH: Skeletal muscle biopsies were obtained from MH-susceptible
(MHS) and MH-negative (MHN) patients. Immunohistochemistry, RT-PCR, Western blot,
and in vitro contracture test (IVCT) were carried out. Development and
characterization of primary human skeletal muscle cells (PHSKMC) and evaluation
of cell membrane potential were also performed. The persulfidation state of Kv 7
channels and polysulfide levels were measured.
KEY RESULTS: Kv 7 channels were similarly expressed in MHN and MHS biopsies. The
IVCT revealed an anomalous contractility of MHS biopsies following exposure to
the Kv 7 channel opener retigabine. Incubation of negative biopsies with NaHS,
prior to retigabine addition, led to an MHS-like positive response. MHS-derived
PHSKMC challenged with retigabine showed a paradoxical depolarizing effect,
compared with the canonical hyperpolarizing effect. CBS expression and activity
were increased in MHS biopsies, resulting in a major polysulfide bioavailability.
Persulfidation of Kv 7.4 channels was significantly higher in MHS than in MHN
biopsies.
CONCLUSIONS AND IMPLICATIONS: In skeletal muscle of MHS patients, CBS-derived H2
S induced persulfidation of Kv 7 channels. This post-translational modification
switches the hyperpolarizing activity into depolarizing. This mechanism can
contribute to the pathological skeletal muscle hypercontractility typical of MH
syndrome
Monitoring and predicting the risk of violence in residential facilities. No difference between patients with history or with no history of violence
none34noopende Girolamo, Giovanni; Buizza, Chiara; Sisti, Davide; Ferrari, Clarissa; Bulgari, Viola; Iozzino, Laura; Boero, Maria Elena; Cristiano, Giuseppe; De Francesco, Alessandra; Giobbio, Gian Marco; Maggi, Paolo; Rossi, Giuseppe; Segalini, Beatrice; Candini, Valentina; Andreose, Suor; Basso, Pasquale; Beneduce, Rossella; Bertolotti, Pietro; Braida, Vanda; Bonelli, Marina; Bongiorno, Fanny; Bussi, Riccardo; Castagno, Elisa; Dominicis, Fabio; Ghersi, Loredana; Greppo, Stefania; Sodano, Alessandro Jaretti; Leporatti, Massimo; Presti, Eleonora Lo; Milone, Valeria; Panigada, Fausto; Pasquadibisceglie, Livia; Rigamonti, Danilo; Rillosi, Lucianade Girolamo, Giovanni; Buizza, Chiara; Sisti, Davide; Ferrari, Clarissa; Bulgari, Viola; Iozzino, Laura; Boero, Maria Elena; Cristiano, Giuseppe; De Francesco, Alessandra; Giobbio, Gian Marco; Maggi, Paolo; Rossi, Giuseppe; Segalini, Beatrice; Candini, Valentina; Andreose, Suor; Basso, Pasquale; Beneduce, Rossella; Bertolotti, Pietro; Braida, Vanda; Bonelli, Marina; Bongiorno, Fanny; Bussi, Riccardo; Castagno, Elisa; Dominicis, Fabio; Ghersi, Loredana; Greppo, Stefania; Sodano, Alessandro Jaretti; Leporatti, Massimo; Presti, Eleonora Lo; Milone, Valeria; Panigada, Fausto; Pasquadibisceglie, Livia; Rigamonti, Danilo; Rillosi, Lucian