EL TRABAJO COOPERATIVO.

This article aims to give an overview about the cooperative work among students as this is not only a very effective resource to teach students, but also a school freshest content that students must learn throughout their schooling. Therefore it is an aspect that we consider of great importance, which will focus in this paper to secondary school students to encourage them sociability and interaction among equals. To help students learn teamwork is very important to form teams of stable employment for a considerable time. As outlined below, this will work through different activities in which students must take a positive and cooperative attitude

El trabajo cooperativo

Este artículo pretende dar una visión a cerca del trabajo cooperativo en el alumnado ya que éste no sólo es un recurso muy eficaz para enseñar a los alumnos, sino que también es un contenido escolar más que los alumnos deben aprender a lo largo de su escolaridad. Por lo tanto es un aspecto que consideramos de gran importancia, el cual enfocaremos en este trabajo hacia el alumnado de secundaria para fomentar en ellos la sociabilidad e interacción entre iguales.Para que los alumnos aprendan a trabajar en equipo es muy importante que formen equipos de trabajo estables durante un tiempo considerable. Como veremos a continuación, esto lo trabajaremos a través de diferentes actividades en las que el alumnado debe adoptar una actitud positiva y de cooperación

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality