Constraining the geodynamic evolution of the Alps with sedimentary provenance and detrital thermochronometer data, II. Detrital thermochronology

This project was designed to disentangle sedimentary signals controlled by changes in the lithosphere, the upper crust, and climate change in the European Alps. The hypothesis was that if lithospheric reorganisation in the Alps (such as slab break-off or tearing) occurred, it would lead to spatio-temporal changes in buoyancy, influencing the location of rock uplift and erosion. Specifically, we wanted to test this hypothesis using a multi-proxy provenance approach (sedimentary provenance tools, detrital thermochronology) at key stratigraphic time slices (28, 25, 20, 17, 15, and 12 Ma) from the northern and southern foreland basins. Foreland basin deposits represent a rich archive of erosional processes controlled by tectonics, climate, and lithology. This presentation concerns part II of the study, the detrital thermochronology, which we use as "tracer thermochronology". Applications of tracer thermochronology exploit a known or assumed surface thermochronometric age map (based on either interpolated observed or modelled bedrock ages) to determine the provenance of detrital grains within fluvial or glacial catchments. The goal is to interpret the erosion pattern and processes within the sampled catchment. Before reconstructing and interpreting past erosion patterns and exhumation from detrital zircon fission-track (ZFT) age distributions and modelled bedrock ZFT ages back in time, we produce a frame of reference for today's situation. We do this by investigating signals from 26 modern river samples (21 previous [1,2] and nine new samples) and the present-day erosion pattern and mineral fertility in the Alps. We discuss observed and predicted (based on possible erosion scenarios) ZFT age distributions and potential pitfalls of the method (such as poor bedrock control in some areas of the Alps and challenges in combining previous and new data). Modern river results are consistent for adjacent, similar-size catchments and with expected erosion patterns. Most samples show a higher proportion of younger ZFT ages than would be predicted for uniform erosion and zircon fertility scenarios. Furthermore, we show preliminary results from stratigraphic sections from north and south of the Alps

Jugendliche in Niedersachsen : Ergebnisse des Niedersachsensurveys 2019

Der Artikel unterliegt bis zum 01.01.2022 einem Embargo

Jugendliche in Niedersachsen

JUGENDLICHE IN NIEDERSACHSEN Jugendliche in Niedersachsen / Bergmann, Marie Christine (Rights reserved) ( -

Jugendliche in Niedersachsen : Ergebnisse des Niedersachsensurveys 2017

JUGENDLICHE IN NIEDERSACHSEN Jugendliche in Niedersachsen / Bergmann, Marie Christine (Rights reserved) ( -

Associations between classroom normative climate and the perpetration of teen dating violence among secondary school students

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Witness: The Modern Writer as Witness

Editor\u27s Note [Excerpt] The United States, as a society, is on the brink of profound and positive change. Demographically and culturally, things are improving, and the reason is obvious to people who study history: Conflict pushes us to be better, to strive for principled goals. Consider the inspired eco-advocacy of Greta Thunberg. Or the swearing in of most diverse class of lawmakers in history into the 116th Congress. Or billionaire Robert F. Smith’s pledge to pay off every Morehouse College (in Atlanta, Georgia) student’s debt. Indeed, there are many good people helping and great moments happening in spite of a bleak 24-hour news cycle designed to ruin happiness and to limit our understanding of our human potential. We at Witness see this yearning for transformation in the works we selected. The doorway must be crossed, and the voices and characters we featured in our Winter 2019 issue stand at the vestibule, ready for the light to warm them, primed to fight for that necessary illumination.https://digitalscholarship.unlv.edu/witness/1000/thumbnail.jp

Axonal plasticity in response to active forces generated through magnetic nano-pulling

Mechanical force is crucial in guiding axon outgrowth before and after synapse formation. This process is referred to as "stretch growth." However, how neurons transduce mechanical input into signaling pathways remains poorly understood. Another open question is how stretch growth is coupled in time with the intercalated addition of new mass along the entire axon. Here, we demonstrate that active mechanical force generated by magnetic nano-pulling induces remodeling of the axonal cytoskeleton. Specifically, the increase in the axonal density of microtubules induced by nano-pulling leads to an accumulation of organelles and signaling vesicles, which, in turn, promotes local translation by increasing the probability of assembly of the "translation factories." Modulation of axonal transport and local translation sustains enhanced axon outgrowth and synapse maturation

Succinate accumulation drives ischaemia-reperfusion injury during organ transplantation.

During heart transplantation, storage in cold preservation solution is thought to protect the organ by slowing metabolism; by providing osmotic support; and by minimising ischaemia-reperfusion (IR) injury upon transplantation into the recipient1,2. Despite its widespread use our understanding of the metabolic changes prevented by cold storage and how warm ischaemia leads to damage is surprisingly poor. Here, we compare the metabolic changes during warm ischaemia (WI) and cold ischaemia (CI) in hearts from mouse, pig, and human. We identify common metabolic alterations during WI and those affected by CI, thereby elucidating mechanisms underlying the benefits of CI, and how WI causes damage. Succinate accumulation is a major feature within ischaemic hearts across species, and CI slows succinate generation, thereby reducing tissue damage upon reperfusion caused by the production of mitochondrial reactive oxygen species (ROS)3,4. Importantly, the inevitable periods of WI during organ procurement lead to the accumulation of damaging levels of succinate during transplantation, despite cooling organs as rapidly as possible. This damage is ameliorated by metabolic inhibitors that prevent succinate accumulation and oxidation. Our findings suggest how WI and CI contribute to transplant outcome and indicate new therapies for improving the quality of transplanted organs.Work in the M.P.M. laboratory was supported by the Medical Research Council UK (MC_U105663142) and by a Wellcome Trust Investigator award (110159/Z/15/Z) to M.P.M. Work in the C.F. laboratory was supported by the Medical Research Council (MRC_MC_UU_12022/6). Work in the K.S.P. laboratory was supported by the Medical Research Council UK. Work in the RCH lab laboratory was supported by a Wellcome Trust Investigator award (110158/Z/15/Z) and a PhD studentship for .L.P from the University of Glasgow. A.V.G. was supported by a PhD studentship funded by the National Institute for Health Research Blood and Transplant Research Unit (NIHR BTRU) in Organ Donation and Transplantation at the University of Cambridge in collaboration with Newcastle University and in partnership with NHS Blood and Transplant (NHSBT)