Diagnostic and Prognostic Value of microRNAs in Patients with Laryngeal Cancer: A Systematic Review

: Laryngeal squamous cell cancer (LSCC) is one of the most common malignant tumors of the head and neck region, with a poor survival rate (5-year overall survival 50-80%) as a consequence of an advanced-stage diagnosis and high recurrence rate. Tobacco smoking and alcohol abuse are the main risk factors of LSCC development. An early diagnosis of LSCC, a prompt detection of recurrence and a more precise monitoring of the efficacy of different treatment modalities are currently needed to reduce the mortality. Therefore, the identification of effective diagnostic and prognostic biomarkers for LSCC is crucial to guide disease management and improve clinical outcomes. In the past years, a dysregulated expression of small non-coding RNAs, including microRNAs (miRNAs), has been reported in many human cancers, including LSCC, and many miRNAs have been explored for their diagnostic and prognostic potential and proposed as biomarkers. We searched electronic databases for original papers that were focused on miRNAs and LSCC, using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) protocol. According to the outcome, 566 articles were initially screened, of which 177 studies were selected and included in the analysis. In this systematic review, we provide an overview of the current literature on the function and the potential diagnostic and prognostic role of tissue and circulating miRNAs in LSCC

A new viable region of the inert doublet model

The inert doublet model, a minimal extension of the Standard Model by a second Higgs doublet, is one of the simplest and most attractive scenarios that can explain the dark matter. In this paper, we demonstrate the existence of a new viable region of the inert doublet model featuring dark matter masses between Mw and about 160 GeV. Along this previously overlooked region of the parameter space, the correct relic density is obtained thanks to cancellations between different diagrams contributing to dark matter annihilation into gauge bosons (W+W- and ZZ). First, we explain how these cancellations come about and show several examples illustrating the effect of the parameters of the model on the cancellations themselves and on the predicted relic density. Then, we perform a full scan of the new viable region and analyze it in detail by projecting it onto several two-dimensional planes. Finally, the prospects for the direct and the indirect detection of inert Higgs dark matter within this new viable region are studied. We find that present direct detection bounds already rule out a fraction of the new parameter space and that future direct detection experiments, such as Xenon100, will easily probe the remaining part in its entirety.Comment: 27 pages, 16 figure

The story of atomic energy

128 p.; 17 cm

Tarjeta de Laura Fermi a Ramón Ortiz Fornaguera

Carta manuscrita con sobre original.Laura Fermi agradece a Ortiz Fornaguera sus amables palabras de simpatí