The influence of acetaminophen on sprint interval treadmill running: a randomized crossover trial

Although considerable research concerning the efficacy of analgesics in sport exists, there is a paucity of data concerning effects of acute acetaminophen (ACT) ingestion on sprint interval running exercise. This investigation concerned the effect of acute ACT ingestion on eight 30 s maximal treadmill sprints on a non-motorized treadmill, interspersed with two minutes rest in males (n=8, age 26±3 years, height 174±7 cm, mass 71±8 kg) in a placebo-controlled, randomized crossover design. A time x condition repeated measures analysis of variance (ANOVA) determined ACT ingestion did not influence mean power output, peak power output, peak vertical ground reaction force, peak oxygen uptake, or total distance completed (p>.05). Perceived pain was reduced by 8-15% during the final three sprints following ACT ingestion (p<.05). Data presented here suggest ACT may reduce exercise-induced pain during the latter stages of sprint interval treadmill running, without influencing performance

Microscopic Analysis and Quality Assessment of Induced Sputum From Children With Pneumonia in the PERCH Study.

Background. It is standard practice for laboratories to assess the cellular quality of expectorated sputum specimens to check that they originated from the lower respiratory tract. The presence of low numbers of squamous epithelial cells (SECs) and high numbers of polymorphonuclear (PMN) cells are regarded as indicative of a lower respiratory tract specimen. However, these quality ratings have never been evaluated for induced sputum specimens from children with suspected pneumonia. Methods. We evaluated induced sputum Gram stain smears and cultures from hospitalized children aged 1–59 months enrolled in a large study of community-acquired pneumonia. We hypothesized that a specimen representative of the lower respiratory tract will contain smaller quantities of oropharyngeal flora and be more likely to have a predominance of potential pathogens compared to a specimen containing mainly saliva. The prevalence of potential pathogens cultured from induced sputum specimens and quantity of oropharyngeal flora were compared for different quantities of SECs and PMNs. Results. Of 3772 induced sputum specimens, 2608 (69%) had \u3c10 SECs per low-power field (LPF) and 2350 (62%) had \u3e25 PMNs per LPF, measures traditionally associated with specimens from the lower respiratory tract in adults. Using isolation of low quantities of oropharyngeal flora and higher prevalence of potential pathogens as markers of higher quality, \u3c10 SECs per LPF (but not \u3e25 PMNs per LPF) was the microscopic variable most associated with high quality of induced sputum. Conclusions. Quantity of SECs may be a useful quality measure of induced sputum from young children with pneumonia

Non-invasive genotyping and spatial mark-recapture methods to estimate European pine marten density in forested landscapes

Accurate population density estimates are important for conservation but can be difficult to obtain where species are elusive or rare. Non-invasive genotyping from hair or faeces has provided a promising solution and allowed individual identification from genotypes to inform population assessment models. We use individual genotypes derived from hair samples and Spatially Explicit Capture Recapture (SECR) models to estimate the population density of European pine marten (Martes martes) in three Scottish forests, then examine the effects of forest fragmentation on population size. Relative trends in pine marten abundance can be observed via changes in the number of scats in an area through time, but the link between this measure and population density remains unclear. We provide the first calibration of scat counts to enable population density estimation without the need for genetic analysis. Population density estimates ranged from 0.07 km-2 (95% CI 0.03 – 0.16) to 0.38 km-2 (95% CI 0.11 – 1.07), which were mid to low compared to other estimates from the Scottish population. An unequal sex ratio was found in one of the three forests. We found support for the previous finding that pine marten density in Scotland increases with forest fragmentation up to a threshold level (20 – 35% forest cover), beyond which it decreases. Our calibration suggests a non-linear relationship between scat counts and population density, although relatively small changes in population density result in marked changes in scat number. Following the recent re-introduction of pine martens to Wales, non-invasive genetic sampling for population estimation may provide an effective way of monitoring their progress

Positive Health and Health Assets: Re-analysis of Longitudinal Datasets

Most approaches to health over the centuries have focused on the absence of illness. In contrast, we are investigating Positive Health —well-being beyond the mere absence of disease. In this article, we describe our theoretical framework and empirical work to date on Positive Health. Positive Health empirically identifies health assets by determining factors that predict health and illness over and above conventional risk factors. Biological health assets might include, for example, high heart rate variability, high levels of HDL, and cardiorespiratory fitness. Subjective health assets might include positive emotions, life satisfaction, hope, optimism, and a sense of meaning and purpose. Functional health assets might include close friends and family members; a stable marriage; meaningful work; participation in a social community; and the ability to carry out work, family, and social roles

The influence of fitness on exercise blood pressure and its association with cardiac structure in adolescence

Purpose: Exaggerated exercise blood pressure (BP) is associated with altered cardiac structure and increased cardiovascular risk. Fitness modifies these associations, but the effect in healthy adolescents is unknown. We performed an observational study to determine the influence of fitness on post-exercise BP, and on its relationship with cardiac structure in adolescents. Methods: 4835 adolescents from the Avon Longitudinal Study of Parents and Children, (15.4 (0.3) years, 49% male) completed a submaximal cycle test. Fitness was estimated as physical work capacity 170 adjusted for lean body mass and post-exercise BP measured immediately posttest. Cardiovascular structure and function, including left ventricular (LV) mass (n = 1589), left atrium (LA) size (n = 1466), cardiac output (CO, n = 1610), and total peripheral resistance (TPR, n = 1610) were measured at rest by echocardiography 2.4 (0.4) years later. Results: Post-exercise systolic BP increased stepwise by fitness tertile (131.2 mm Hg [130.4, 132.1]; 137.3 mm Hg [136.5, 138.0]; 142.3 mm Hg [141.5, 143.1]). Each 5 mm Hg of post-exercise systolic BP was associated with 2.46 g [1.91, 3.01] greater LV mass, 0.02 cm [0.02, 0.03] greater LA size, and 0.25 g/m2.7 [0.14, 0.36] greater LV mass index. Adjustment for fitness abolished associations (0.29 g [-0.16, 0.74]; 0.01 cm [-0.001, 0.014] and 0.08 g/m2.7 [-0.001, 0.002]). Similar associations between post-exercise systolic BP and each outcome were found between the lowest and highest fitness thirds. CO increased with fitness third (difference 0.06 L/min [-0.05, 0.17]; 0.23 L/min [0.12, 0.34]) while TPR decreased (difference -0.13 mm Hg·min/L [-0.84,0.59]; -1.08 mm Hg·min/L [-0.1.80, 0.35]). Conclusions: Post-exercise systolic BP increased with fitness, which modified its association with cardiac structure. Higher CO, but lower TPR suggests a physiologically adapted cardiovascular system with greater fitness, highlighting the importance of fitness in adolescence

Safety of Induced Sputum Collection in Children Hospitalized With Severe or Very Severe Pneumonia.

Background.: Induced sputum (IS) may provide diagnostic information about the etiology of pneumonia. The safety of this procedure across a heterogeneous population with severe pneumonia in low- and middle-income countries has not been described. Methods.: IS specimens were obtained as part a 7-country study of the etiology of severe and very severe pneumonia in hospitalized childrenbefore, during, and after the procedure to record oxygen requirement, oxygen saturation, respiratory rate, consciousness level, and other evidence of clinical deterioration. Criteria for IS contraindications were predefined and serious adverse events (SAEs) were reported to ethics committees and a central safety monitor. Results.: A total of 4653 IS procedures were done among 3802 children. Thirteen SAEs were reported in relation to collection of IS, or 0.34% of children with at least 1 IS specimen collected (95% confidence interval, 0.15%-0.53%). A drop in oxygen saturation that required supplemental oxygen was the most common SAE. One child died after feeding was reinitiated 2 hours after undergoing sputum induction; this death was categorized as possibly related to the procedure. Conclusions.: The overall frequency of SAEs was very low, and the nature of most SAEs was manageable, demonstrating a low-risk safety profile for IS collection even among severely ill children in low-income-country settings. Healthcare providers should monitor oxygen saturation and requirements during and after IS collection, and assess patients prior to reinitiating feeding after the IS procedure, to ensure patient safety

The Diagnostic Utility of Induced Sputum Microscopy and Culture in Childhood Pneumonia.

Background. Sputum microscopy and culture are commonly used for diagnosing the cause of pneumonia in adults but are rarely performed in children due to difficulties in obtaining specimens. Induced sputum is occasionally used to investigate lower respiratory infections in children but has not been widely used in pneumonia etiology studies. Methods. We evaluated the diagnostic utility of induced sputum microscopy and culture in patients enrolled in the Pneumonia Etiology Research for Child Health (PERCH) study, a large study of community-acquired pneumonia in children aged 1–59 months. Comparisons were made between induced sputum samples from hospitalized children with radiographically confirmed pneumonia and children categorized as nonpneumonia (due to the absence of prespecified clinical and laboratory signs and absence of infiltrate on chest radiograph). Results. One induced sputum sample was available for analysis from 3772 (89.1%) of 4232 suspected pneumonia cases enrolled in PERCH. Of these, sputum from 2608 (69.1%) met the quality criterion of \u3c10 squamous epithelial cells per low-power field, and 1162 (44.6%) had radiographic pneumonia. Induced sputum microscopy and culture results were not associated with radiographic pneumonia, regardless of prior antibiotic use, stratification by specific bacteria, or interpretative criteria used. Conclusions. The findings of this study do not support the culture of induced sputum specimens as a diagnostic tool for pneumonia in young children as part of routine clinical practice

Growth Motivation and Well-Being in the U.S., Japan, Guatemala, and India

The present study examined how the Growth Motivation Index (GMI; J. J. Bauer et al., 2015) related to well-being and identity exploration in samples from the U.S., Japan, Guatemala, and India. The GMI has two facets. GMI-reflective measures the motive to cultivate critical self-reflection and intellectual development, whereas GMI-experiential measures the motive to cultivate personally meaningful activities and relationships. We expected and found that, when comparing the two GMI facets simultaneously, GMI-reflective predicted well-being in countries ranked as having collectivist but not individualist cultures, whereas GMI-experiential predicted well-being in countries ranked as having individualist but not collectivist cultures. GMI-reflective predicted identity exploration across cultures. Implications for growth motivation and culture are discussed

Parenting while living with advanced cancer: A qualitative study

Patients with advanced cancer who have dependent children are an important population with a life-limiting illness and high levels of psychological distress. Few studies have addressed the experience of being a parent with advanced cancer and their potential palliative needs

Masked hypertension and submaximal exercise blood pressure among adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC)

Purpose: Masked hypertension is associated with increased cardiovascular risk but is undetectable by clinic blood pressure (BP). Elevated systolic BP responses to submaximal exercise reveal the presence of masked hypertension in adults, but it is unknown whether this is the case during adolescence. We aimed to determine if exercise BP was raised in adolescents with masked hypertension, and its association with cardiovascular risk markers.Methods: A total of 657 adolescents (aged 17.7 ± 0.3 years; 41.9% male) from the Avon longitudinal study of parents and children (ALSPAC) completed a step-exercise test with pre-, post-, and recovery-exercise BP, clinic BP and 24-hour ambulatory BP. Masked hypertension was defined as clinic BP Results: Fifty participants (7.8%) were classified with masked hypertension. Clinic, pre-, post-, and recovery-exercise systolic BP were associated with masked hypertension (AUC ≥ 0.69 for all, respectively), with the clinic systolic BP threshold of 115 mm Hg having high sensitivity and specificity and exercise BP thresholds of 126, 150, and 130 mm Hg, respectively, having high specificity and negative predictive value (individually or when combined) for ruling out the presence of masked hypertension. Additionally, this exercise systolic BP above the thresholds was associated with greater left-ventricular mass index and aortic PWV.Conclusions: Submaximal exercise systolic BP is associated with masked hypertension and adverse cardiovascular structure in adolescents. Exercise BP may be useful in addition to clinic BP for screening of high BP and cardiovascular risk in adolescents