Exploring concept representations for concept drift detection

We present an approach to estimating concept drift in online news. Our method is to construct temporal concept vectors from topicannotated news articles, and to correlate the distance between the temporal concept vectors with edits to the Wikipedia entries of the concepts. We find improvements in the correlation when we split the news articles based on the amount of articles mentioning a concept, instead of calendar-based units of time

Expanding the realms of sport psychology in esports: an epilogue

In this epilogue to the special issue, we provide a summary of four case studies in esports. Specifically, we draw attention to (1) interventions with teams and esports athletes, (2) coach support and development, and (3) practitioner development. We explore these areas in relation to the case studies presented in the special issue, providing a structured analysis and discussion of the experiences shared in these case studies and shedding light on how sport psychology is applied in esports. Lastly, we offer future research and practice opportunities for those intending to practice or currently practicing in the realm of esports

Medida del emprendizaje: adaptación y validación de la escala de actitudes emprendedoras EASS en profesores españoles

The aim of this study is to offer an assessment instrument to know the entrepreneurial attitudes of the professorate or educators (EAST), adapted from the Entrepreneurial Attitudes Scale for Students (EASS), and also to provide a first approximation to diagnosis in the field of Spanish-speaking context. A cross-sectional on-line survey was carried out in a single time, in which 155 teachers participated. The new adapted instrument, based on the Entrepreneurial Attitudes Scale for Students (EASS), assesses six entrepreneurial attitudes: proactivity, professional ethics, empathy, innovation, autonomy, and risk taking that define the individual with motivation towards entrepreneurship. Confirmatory factor analysis provides appropriate results: χ2 (120) = 214.225 (p < .001), CFI = .963, TLI = .953, SRMR = .011, RMSEA = .071. Reliability estimations are also calculated, with Cronbach’s alphas ranging from .95 to .97 for the six dimensions. A negative relation regarding entrepreneurship and age is found, as well as higher levels of entrepreneurial attitudes in women than in men. Results show appropriate psychometric properties. As far as literature has been revised, the adaptation presented here is the only developed for this purpose in Spanish-speaking context so far.El objetivo de este trabajo es ofrecer un instrumento de evaluación que permita conocer las actitudes emprendedoras del profesorado, mediante la adaptación de la original Escala de Actitudes Emprendedoras para Estudiantes, al tiempo que facilitar una primera aproximación a su diagnóstico en el ámbito español, con proyección en el área de habla hispana. En el marco de un diseño transversal, se llevó a cabo una encuesta on-line en un único momento temporal en la que participaron 155 profesionales de la educación. El instrumento adaptado (Escala de Actitudes Emprendedoras para Profesores, EAST), basado en la Escala de Actitudes Emprendedoras para Estudiantes de Oliver y Galiana (2016), evalúa 6 actitudes emprendedoras con 18 ítems: proactividad, ética profesional, empatía, innovación, autonomía y toma de riesgos, que definen a la persona con motivación hacia el emprendimiento. El análisis factorial confirmatorio ofrece resultados adecuados: χ2 (120) = 214.225 (p < .001), CFI = .963, TLI = .953, SRMR = .011, RMSEA = .071. Se obtienen estimaciones de fiabilidad excelentes, con alfas de Cronbach de .95 a .97 para las seis dimensiones. Se detecta una relación negativa del emprendimiento con la edad, y una mayor presencia en mujeres. Los resultados muestran unas propiedades psicométricas adecuadas de la nueva adaptación, siendo este, hasta donde se conoce, el primero desarrollado para evaluar en educadores actitudes emprendedoras en el contexto hispano-hablante

OH detection by absorption of frequency-doubled diode laser radiation at 308nm

Radiation at 308 nm has been obtained by frequency doubling the output of a commercial diode laser cooled to 165 K. A single pass through a crystal of LiIO3 converted 1 mW of 616 nm radiation to 50 pW of UV, and this was used to detect the OH radical in absorption in a flow tube. Possible extensions of the method for detection of OH in the atmosphere are discussed

The Association Between Parity and Subsequent Cardiovascular Disease in Women: The Atherosclerosis Risk in Communities Study.

Background: Previous studies are inconclusive on the relationship between parity and cardiovascular disease (CVD), with few evaluating multiple cardiovascular outcomes. It is also unclear if any relationship between parity and CVD is independent of breastfeeding. We examined the associations between parity and cardiovascular outcomes, including breastfeeding adjustment. Materials and Methods: Data were from 8,583 White and African American women, 45-64 years of age, in the Atherosclerosis Risk in Communities Study. Coronary heart disease (CHD), myocardial infarction (MI), heart failure, and strokes were ascertained from 1987 to 2016 by annual interviews and hospital surveillance. Parity and breastfeeding were self-reported. Cox proportional hazards regression estimated hazard ratios (HR) for the association between parity and cardiovascular outcomes, adjusting for baseline sociodemographic, clinical and lifestyle factors, and breastfeeding. Results: Women reported no pregnancies (6.0%), or having 0 (1.6%), 1-2 (36.2%), 3-4 (36.4%), or 5+ (19.7%) live births. During 30 years follow-up, there were 1,352 CHDs, 843 MIs, 750 strokes, and 1,618 heart failure events. Compared with women with 1-2 prior births, those with prior pregnancies and no live births had greater incident CHD (HR = 1.64, 95% confidence interval 1.14-2.42) and heart failure risk (1.46, 1.04-2.05), after adjustment for baseline characteristics. Women with 5+ births had greater risk of CHD (1.29, 1.10-1.52) and hospitalized MI (1.38, 1.13-1.69), after adjustment for baseline characteristics and breastfeeding. Conclusions: In a diverse U.S. cohort, a history of 5+ live births is associated with CHD risk, specifically, MI, independent of breastfeeding. Having a prior pregnancy and no live birth is associated with greater CHD and heart failure risk.This work was also supported by the British Heart Foundation Cambridge Centre of Excellence, (RE/13/6/30180) and Homerton College, University of Cambridge The Atherosclerosis Risk in Communities study has been funded in whole or in part with Federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, under Contract nos. (HHSN268201700001I, HHSN268201700002I, HHSN268201700003I, HHSN268201700005I, HHSN268201700004I)

LL-37 and HMGB1 induce alveolar damage and reduce lung tissue regeneration via RAGE

The receptor for advanced glycation end-products (RAGE) has been implicated in the pathophysiology of chronic obstructive pulmonary disease (COPD). However, it is still unknown whether RAGE directly contributes to alveolar epithelial damage and abnormal repair responses. We hypothesize that RAGE activation not only induces lung tissue damage but also hampers alveolar epithelial repair responses. The effects of the RAGE ligands LL-37 and HMGB1 were examined on airway inflammation and alveolar tissue damage in wild-type and RAGE-deficient mice and on lung damage and repair responses using murine precision cut lung slices (PCLS) and organoids. In addition, their effects were studied on the repair response of human alveolar epithelial A549 cells, using siRNA knockdown of RAGE and treatment with the RAGE inhibitor FPS-ZM1. We observed that intranasal installation of LL-37 and HMGB1 induces RAGE-dependent inflammation and severe alveolar tissue damage in mice within 6 h, with stronger effects in a mouse strain susceptible for emphysema compared with a nonsusceptible strain. In PCLS, RAGE inhibition reduced the recovery from elastaseinduced alveolar tissue damage. In organoids, RAGE ligands reduced the organoid-forming efficiency and epithelial differentiation into pneumocyte-organoids. Finally, in A549 cells, we confirmed the role of RAGE in impaired repair responses upon exposure to LL-37. Together, our data indicate that activation of RAGE by its ligands LL-37 and HMGB1 induces acute lung tissue damage and that this impedes alveolar epithelial repair, illustrating the therapeutic potential of RAGE inhibitors for lung tissue repair in emphysema

Long Spin Coherence and Relaxation Times in Nanodiamonds Milled from Polycrystalline 12^{12}C Diamond

The negatively charged nitrogen-vacancy centre (NV$^-$) in diamond has been utilized in a wide variety of sensing applications. The centre's long spin coherence and relaxation times ($T_2^*$, $T_2$ and $T_1$) at room temperature are crucial to this, as they often limit sensitivity. Using NV$^-$ centres in nanodiamonds allows for operations in environments inaccessible to bulk diamond, such as intracellular sensing. We report long spin coherence and relaxation times at room temperature for single NV$^-$ centres in isotopically-purified polycrystalline ball-milled nanodiamonds. Using a spin-locking pulse sequence, we observe spin coherence times, $T_2$, up 786 $\pm$ 200 $\mu$s. We also measure $T_2^*$ times up to 2.06 $\pm$ 0.24 $\mu$s and $T_1$ times up to 4.32 $\pm$ 0.60 ms. Scanning electron microscopy and atomic force microscopy measurements show that the diamond containing the NV$^{-}$ centre with the longest $T_1$ time is smaller than 100 nm. EPR measurements give an N$_{s}$$^{0}$ concentration of 0.15 $\pm$ 0.02 ppm for the nanodiamond sample.Comment: 13 pages, 3 figure

Outcomes of the 2019 GRAPPA workshop on continuous composite indices for the assessment of psoriatic arthritis and membership-recommended next steps

OBJECTIVE: Improving the assessment of psoriatic arthritis (PsA) is a key purpose of the Group for Research and Assessment of Psoriasis and PsA (GRAPPA). Herein, we report the proceedings of the GRAPPA composites workshop at the 2019 GRAPPA annual meeting and the membership\u27s recommended next steps. METHODS: A review of continuous composite measures was conducted in an introductory workshop, followed by 10 breakout group sessions and a final plenary session for feedback and voting. RESULTS: Participants included 154 members: 87 rheumatologists, 18 dermatologists, 2 rheumatologist/dermatologists, 12 patient research partners, 14 academics, 1 methodologist, and 20 industry members. Of voting members, 88.8% agreed a need exists for a continuous composite measure for routine practice, but only 62% were currently using a composite measure. Of these, 27% were using the 28-joint count Disease Activity Score (DAS), which is not a PsA-specific measure; 20% were using a PsA-specific measure such as PsA DAS (PASDAS), Composite Psoriatic Disease Activity Index (CPDAI), or Disease Activity Index for PsA (DAPSA). Members agreed that the existing measures were not feasible in their current forms (CPDAI 83%, PASDAS 82%, and DAPSA 47%) and that modification should be tested. The majority (76%) agreed that disease effect should be measured separately from disease activity. CONCLUSION: The GRAPPA membership supports the need for a continuous composite measure of disease activity for use in routine clinical care, the separate measurement of disease effect and activity, and the testing of modifications to candidate instruments rather than the development of new measures