Void Dynamics

Cosmic voids are becoming key players in testing the physics of our Universe. Here we concentrate on the abundances and the dynamics of voids as these are among the best candidates to provide information on cosmological parameters. Cai, Padilla \& Li (2014) use the abundance of voids to tell apart Hu \& Sawicki $f(R)$ models from General Relativity. An interesting result is that even though, as expected, voids in the dark matter field are emptier in $f(R)$ gravity due to the fifth force expelling away from the void centres, this result is reversed when haloes are used to find voids. The abundance of voids in this case becomes even lower in $f(R)$ compared to GR for large voids. Still, the differences are significant and this provides a way to tell apart these models. The velocity field differences between $f(R)$ and GR, on the other hand, are the same for halo voids and for dark matter voids. Paz et al. (2013), concentrate on the velocity profiles around voids. First they show the necessity of four parameters to describe the density profiles around voids given two distinct void populations, voids-in-voids and voids-in-clouds. This profile is used to predict peculiar velocities around voids, and the combination of the latter with void density profiles allows the construction of model void-galaxy cross-correlation functions with redshift space distortions. When these models are tuned to fit the measured correlation functions for voids and galaxies in the Sloan Digital Sky Survey, small voids are found to be of the void-in-cloud type, whereas larger ones are consistent with being void-in-void. This is a novel result that is obtained directly from redshift space data around voids. These profiles can be used to remove systematics on void-galaxy Alcock-Pacinsky tests coming from redshift-space distortions.Comment: 8 pages, 4 figures, to appear in the proceedings of IAU308 Symposium "The Zeldovich Universe

Clues on void evolution II: Measuring density and velocity profiles on SDSS galaxy redshift space distortions

Using the redshift-space distortions of void-galaxy cross-correlation function we analyse the dynamics of voids embedded in different environments. We compute the void-galaxy crosscorrelation function in the Sloan Digital Sky Survey (SDSS) in terms of distances taken along the line of sight and projected into the sky. We analyse the distortions on the cross-correlation isodensity levels and we find anisotropic isocontours consistent with expansion for large voids with smoothly rising density profiles and collapse for small voids with overdense shells surrounding them. Based on the linear approach of gravitational collapse theory we developed a parametric model of the void-galaxy redshift space cross-correlation function. We show that this model can be used to successfully recover the underlying velocity and density profiles of voids from redshift space samples. By applying this technique to real data, we confirm the twofold nature of void dynamics: large voids typically are in an expansion phase whereas small voids tend to be surrounded by overdense and collapsing regions. These results are obtained from the SDSS spectroscopic galaxy catalogue and also from semi-analytic mock galaxy catalogues, thus supporting the viability of the standard ΛCDM model to reproduce large scale structure and dynamics.Fil: Paz, Dante Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomia Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomia Teórica y Experimental; ArgentinaFil: Lares Harbin Latorre, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomia Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomia Teórica y Experimental; ArgentinaFil: Ceccarelli, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomia Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomia Teórica y Experimental; ArgentinaFil: Padilla, Nelson David. Pontificia Universidad Católica de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia Lambas, Diego Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomia Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomia Teórica y Experimental; Argentin

Clues on void evolution – I. Large-scale galaxy distributions around voids

We perform a statistical study focused on void environments. We examine galaxy density profiles around voids in the Sloan Digital Sky Survey (SDSS), finding a correlation between void-centric distance to the shell of maximum density and void radius when a maximum in overdensity exists. We analyse voids with and without a surrounding overdense shell in the SDSS. We find that small voids are more frequently surrounded by overdense shells whereas the radial galaxy density profile of large voids tends to rise smoothly towards the mean galaxy density. We analyse the fraction of voids surrounded by overdense shells finding a continuous trend with void radius. The differences between voids with and without an overdense shell around them can be understood in terms of whether the voids are, on average, in the process of collapsing or continuing their expansion, respectively, in agreement with previous theoretical expectations. We use numerical simulations coupled to semi-analytic models of galaxy formation in order to test and interpret our results. The very good agreement between the mock catalogue results and the observations provides additional support to the viability of a Λ cold dark matter model to reproduce the large-scale structure of the Universe as defined by the void network, in a way which has not been analysed previously.Fil: Ceccarelli, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomia Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomia Teórica y Experimental; ArgentinaFil: Paz, Dante Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomia Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomia Teórica y Experimental; ArgentinaFil: Lares Harbin Latorre, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomia Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomia Teórica y Experimental; ArgentinaFil: Padilla, Nelson David. Pontificia Universidad Católica de Chile; Chile. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Garcia Lambas, Diego Rodolfo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomia Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomia Teórica y Experimental; Argentin

Depression and adult neurogenesis: Positive effects of the antidepressant fluoxetine and of physical exercise

Of wide interest for health is the relation existing between depression, a very common psychological illness, accompanied by anxiety and reduced ability to concentrate, and adult neurogenesis. We will focus on two neurogenic stimuli, fluoxetine and physical exercise, both endowed with the ability to activate adult neurogenesis in the dentate gyrus of the hippocampus, known to be required for learning and memory, and both able to counteract depression. Fluoxetine belongs to the class of selective serotonin reuptake inhibitor (SSRI) antidepressants, which represent the most used pharmacological therapy; physical exercise has also been shown to effectively counteract depression symptoms in rodents as well as in humans. While there is evidence that the antidepressant effect of fluoxetine requires its pro-neurogenic action, exerted by promoting proliferation, differentiation and survival of progenitor cells of the hippocampus, on the other hand fluoxetine exerts also neurogenesis-independent antidepressant effects by influencing the plasticity of the new neurons generated. Similarly, the antidepressant action of running also correlates with an increase of hippocampal neurogenesis and plasticity, although the gene pathways involved are only partially coincident with those of fluoxetine, such as those involved in serotonin metabolism and synapse formation. We further discuss how extra-neurogenic actions are also suggested by the fact that, unlike running, fluoxetine is unable to stimulate neurogenesis during aging, but still displays antidepressant effects. Moreover, in specific conditions, fluoxetine or running activate not only progenitor but also stem cells, which normally are not stimulated; this fact reveals how stem cells have a long-term, hidden ability to self-renew and, more generally, that neurogenesis is subject to complex controls that may play a role in depression, such as the type of neurogenic stimulus or the state of the local niche. Finally, we discuss how fluoxetine or running are effective in counteracting depression originated from stress or neurodegenerative diseases

Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism

In cancer cells, global genomic hypomethylation is found together with localized hypermethylation of CpG islands within the promoters and regulatory regions of silenced tumor suppressor genes. Demethylating agents may reverse hypermethylation, thus promoting gene re-expression. Unfortunately, demethylating strategies are not efficient in solid tumor cells. DNA demethylation is mediated by ten-eleven translocation enzymes (TETs). They sequentially convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC), which is associated with active transcription; 5-formylcytosine; and finally, 5-carboxylcytosine. Although α-linolenic acid, eicosapentaenoic acid (EPA), and docosahexaenoic acid, the major n-3 polyunsaturated fatty acids, have anti-cancer effects, their action, as DNA-demethylating agents, has never been investigated in solid tumor cells. Here, we report that EPA demethylates DNA in hepatocarcinoma cells. EPA rapidly increases 5hmC on DNA, inducing p21Waf1/Cip1 gene expression, which slows cancer cell-cycle progression. We show that the underlying molecular mechanism involves TET1. EPA simultaneously binds peroxisome proliferator-activated receptor γ (PPARγ) and retinoid X receptor α (RXRα), thus promoting their heterodimer and inducing a PPARγ-TET1 interaction. They generate a TET1-PPARγ-RXRα protein complex, which binds to a hypermethylated CpG island on the p21 gene, where TET1 converts 5mC to 5hmC. In an apparent shuttling motion, PPARγ and RXRα leave the DNA, whereas TET1 associates stably. Overall, EPA directly regulates DNA methylation levels, permitting TET1 to exert its anti-tumoral function.-Ceccarelli, V., Valentini, V., Ronchetti, S., Cannarile, L., Billi, M., Riccardi, C., Ottini, L., Talesa, V. N., Grignani, F., Vecchini, A., Eicosapentaenoic acid induces DNA demethylation in carcinoma cells through a TET1-dependent mechanism

Systemic Lupus Erythematosus with and without Anti-dsDNA Antibodies: Analysis from a Large Monocentric Cohort

Objectives. The anti-dsDNA antibodies are a marker for Systemic Lupus Erythematosus (SLE) and 70–98% of patients test positive. We evaluated the demographic, clinical, laboratory, and therapeutical features of a monocentric SLE cohort according to the antidsDNA status. Methods. We identified three groups: anti-dsDNA + (persistent positivity); anti-dsDNA ± (initial positivity and subsequent negativity during disease course); anti-dsDNA − (persistent negativity). Disease activity was assessed by the European Consensus Lupus Activity Measurement (ECLAM). Results. We evaluated 393 patients (anti-dsDNA +: 62.3%; anti-dsDNA ±: 13.3%; anti-dsDNA −: 24.4%). The renal involvement was signifiantly more frequent in anti-dsDNA + (30.2%), compared with antidsDNA ± and anti-dsDNA − (21.1% and 18.7%, resp.; = 0.001). Serositis resulted signifiantly more frequent in anti-dsDNA − (82.3%) compared to anti-dsDNA + and anti-dsDNA ± (20.8% and 13.4%, resp.; < 0.0001). Th reduction of C4 serum levels was identified significantly more frequently in anti-dsDNA + and anti-dsDNA ± (40.0% and 44.2%, resp.) compared with antidsDNA − (21.8%, = 0.005). We did not identify significant differences in the mean ECLAM values before and after modifiation of anti-dsDNA status ( = 0.7). Conclusion. Anti-dsDNA status influences the clinical and immunological features of SLE patients. Nonetheless, it does not appear to affect disease activity

Terminal differentiation of adult hippocampal progenitor cells is a step functionally dissociable from proliferation and is controlled by Tis21, Id3 and NeuroD2

Cell proliferation and differentiation are interdependent processes. Here, we have asked to what extent the two processes of neural progenitor cell amplification and differentiation are functionally separated. Thus, we analyzed whether it is possible to rescue a defect of terminal differentiation in progenitor cells of the dentate gyrus, where new neurons are generated throughout life, by inducing their proliferation and/or their differentiation with different stimuli appropriately timed. As a model we used the Tis21 knockout mouse, whose dentate gyrus neurons, as demonstrated by us and others, have an intrinsic defect of terminal differentiation. We first tested the effect of two proliferative as well as differentiative neurogenic stimuli, one pharmacological (fluoxetine), the other cognitive (the Morris water maze (MWM) training). Both effectively enhanced the number of new dentate gyrus neurons produced, and fluoxetine also reduced the S-phase length of Tis21 knockout dentate gyrus progenitor cells and increased the rate of differentiation of control cells, but neither factor enhanced the defective rate of differentiation. In contrast, the defect of terminal differentiation was fully rescued by in vivo infection of proliferating dentate gyrus progenitor cells with retroviruses either silencing Id3, an inhibitor of neural differentiation, or expressing NeuroD2, a proneural gene expressed in terminally differentiated dentate gyrus neurons. This is the first demonstration that NeuroD2 or the silencing of Id3 can activate the differentiation of dentate gyrus neurons, complementing a defect of differentiation. It also highlights how the rate of differentiation of dentate gyrus neurons is regulated genetically at several levels and that a neurogenic stimulus for amplification of neural stem/progenitor cells may not be sufficient in itself to modify this rat

3D bioprinting and Rigenera® micrografting technology: A possible countermeasure for wound healing in spaceflight

Plant and animal life forms have progressively developed mechanisms for perceiving and responding to gravity on Earth, where homeostatic mechanisms require feedback. Lack of gravity, as in the International Space Station (ISS), induces acute intra-generational changes in the quality of life. These include reduced bone calcium levels and muscle tone, provoking skin deterioration. All these problems reduce the work efficiency and quality of life of humans not only during exposure to microgravity (mu G) but also after returning to Earth. This article discusses forthcoming experiments required under gravity and mu G conditions to ensure effective and successful medical treatments for astronauts during long-term space missions, where healthcare is difficult and not guaranteed

Infall of galaxies onto groups

The growth of the structure within the Universe manifests in the form of accretion flows of galaxies onto groups and clusters. Thus, the present-day properties of groups and their member galaxies are influenced by the characteristics of this continuous infall pattern. Several works both theoretical (in numerical simulations) and observational, have studied this process and provided useful steps for a better understanding of galaxy systems and their evolution. Aims. We aim to explore the streaming flow of galaxies onto groups using observational peculiar velocity data. The effects of distance uncertainties are also analyzed, as well as the relation between the infall pattern and the group and environment properties. Methods. This work deals with the analysis of peculiar velocity data and their projection in the direction of group centers, in order to determine the mean galaxy infall flow. We applied this analysis to the galaxies and groups extracted from the Cosmicflows-3 catalog. We also used mock catalogs derived from numerical simulations to explore the effects of distance uncertainties on the derivation of the galaxy velocity flow onto groups. Results. We determine the infalling velocity field onto galaxy groups with cz < 0.033 using peculiar velocity data. We measured the mean infall velocity onto group samples of different mass ranges, and also explored the impact of the environment where the group resides. Far beyond the group virial radius, the surrounding large-scale galaxy overdensity may impose additional infalling streaming amplitudes in the range of 200-400 km s-1. Also, we find that groups in samples with a well-controlled galaxy density environment show an infalling velocity amplitude that increases with group mass, consistent with the predictions of the linear model. These results from observational data are in excellent agreement with those derived from the mock catalogs.Fil: Santucho, María Victoria. Observatorio Astronomico de la Universidad Nacional de Cordoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; ArgentinaFil: Ceccarelli, Maria Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; Argentina. Observatorio Astronomico de la Universidad Nacional de Cordoba; ArgentinaFil: Garcia Lambas, Diego Rodolfo. Observatorio Astronomico de la Universidad Nacional de Cordoba; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Astronomía Teórica y Experimental. Universidad Nacional de Córdoba. Observatorio Astronómico de Córdoba. Instituto de Astronomía Teórica y Experimental; Argentin

Cognitive dysfunction improves in systemic lupus erythematosus: Results of a 10 years prospective study

Objective Cognitive impairment (CI) has been described in 3–80% of Systemic lupus erythematosus (SLE) patients but only short-term studies evaluated its over-time changes, suggesting that CI is usually a stable finding. We aimed at evaluating the changes of SLE-related CI in a 10-years prospective single center cohort study. Methods We evaluated 43 patients (M/F 5/38; mean age = 45.7±10.1 years; mean disease duration = 230.8±74.3 months) at baseline (T0) and after 10 years (T1). A test battery designed to detect fronto-subcortical dysfunction across five domains (memory, attention, abstract reasoning, executive and visuospatial function) was administered. A global cognitive dysfunction score (GCD) was obtained and associated with clinical and laboratory features. Results Prevalence of CI was 20.9% at T0 and 13.9% at T1 (P = NS). This impairment was prevalently mild at T0 (55.5%) and mild or moderate at T1 (36.3% for both degrees). After 10 years, CI improved in 50% of patients, while 10% worsened. Impaired memory (P = 0.02), executive functions (P = 0.02) and abstract reasoning (P = 0.03) were associated with dyslipidemia at T0. Worsening of visuospatial functions was significantly associated with dyslipidemia and Lupus Anticoagulant (P = 0.04 for both parameters). Finally, GCD significantly correlated with chronic damage measured by SLICC/damage index at T0 (r = 0.3; P = 0.04) and T1 (r = 0.3; P = 0.03). Conclusions For the first time, we assessed CI changes over 10-years in SLE. CI improved in the majority of the patients. Furthermore, we observed an improvement of the overall cognitive functions. These results could suggest that an appropriate management of the disease during the follow-up could be able to control SLE-related CI