24,779 research outputs found
Carbon Rich Extremely Metal Poor Stars: Signatures of Population-III AGB stars in Binary Systems
We use the Cambridge stellar evolution code STARS to model the evolution and
nucleosynthesis of zero-metallicity intermediate-mass stars. We investigate the
effect of duplicity on the nucleosynthesis output of these systems and the
potential abundances of the secondaries. The surfaces of zero-metallicity stars
are enriched in CNO elements after second dredge up. During binary interaction,
such as Roche lobe overflow or wind accretion, metals can be released from
these stars and the secondaries enriched in CNO isotopes. We investigate the
formation of the two most metal poor stars known, HE 0107-5240 and HE
1327-2326. The observed carbon and nitrogen abundances of HE 0107-5240 can be
reproduced by accretion of material from the companion-enhanced wind of a seven
solar star after second dredge-up, though oxygen and sodium are underproduced.
We speculate that HE 1327-2326, which is richer in nitrogen and strontium, may
similarly be formed by wind accretion in a later AGB phase after third
dredge-up.Comment: 16 pages, 1 figure, 7 tables, accepted by MNRA
Radioactive silicon as a marker in thin-film silicide formation
A new technique using radioactive 31Si (half-life =2.62 h), formed in a nuclear reactor, as a marker for studying silicide formation is described. A few hundred angstroms of radioactive silicon is first deposited onto the silicon substrate, followed immediately by the deposition of a few thousand angstroms of the metal. When the sample is heated, a silicide is first formed with the radioactive silicon. Upon further silicide formation, this band of radioactive silicide can move to the surface of the sample if silicide formation takes place by diffusion of the metal or by silicon substitutional and/or vacancy diffusion. However, if the band of radioactive silicide stays at the silicon substrate interface it can be concluded that silicon diffuses by interstitial and/or grain-boundary diffusion. This technique was tested by studying the formation of Ni2Si on silicon at 330 °C. From a combination of ion-beam sputtering, radioactivity measurement, and Rutherford backscattering it is found that the band of radioactive silicide moves to the surface of the sample during silicide formation. From these results, implanted noble-gas marker studies and the rate dependence of Ni2Si growth on grain size, it is concluded that nickel is the dominant diffusing species during Ni2Si formation, and that it moves by grain-boundary diffusion
Artemether resistance in vitro is linked to mutations in PfATP6 that also interact with mutations in PfMDR1 in travellers returning with Plasmodium falciparum infections.
BACKGROUND: Monitoring resistance phenotypes for Plasmodium falciparum, using in vitro growth assays, and relating findings to parasite genotype has proved particularly challenging for the study of resistance to artemisinins.
METHODS: Plasmodium falciparum isolates cultured from 28 returning travellers diagnosed with malaria were assessed for sensitivity to artemisinin, artemether, dihydroartemisinin and artesunate and findings related to mutations in pfatp6 and pfmdr1.
RESULTS: Resistance to artemether in vitro was significantly associated with a pfatp6 haplotype encoding two amino acid substitutions (pfatp6 A623E and S769N; (mean IC50 (95% CI) values of 8.2 (5.7 - 10.7) for A623/S769 versus 623E/769 N 13.5 (9.8 - 17.3) nM with a mean increase of 65%; p = 0.012). Increased copy number of pfmdr1 was not itself associated with increased IC50 values for artemether, but when interactions between the pfatp6 haplotype and increased copy number of pfmdr1 were examined together, a highly significant association was noted with IC50 values for artemether (mean IC50 (95% CI) values of 8.7 (5.9 - 11.6) versus 16.3 (10.7 - 21.8) nM with a mean increase of 87%; p = 0.0068). Previously described SNPs in pfmdr1 are also associated with differences in sensitivity to some artemisinins.
CONCLUSIONS: These findings were further explored in molecular modelling experiments that suggest mutations in pfatp6 are unlikely to affect differential binding of artemisinins at their proposed site, whereas there may be differences in such binding associated with mutations in pfmdr1. Implications for a hypothesis that artemisinin resistance may be exacerbated by interactions between PfATP6 and PfMDR1 and for epidemiological studies to monitor emerging resistance are discussed
Dissociation mechanism for solid-phase epitaxy of silicon in the Si <100>/Pd2Si/Si (amorphous) system
Solid-phase epitaxial growth (SPEG) of silicon was investigated by a tracer technique using radioactive 31Si formed by neutron activation in a nuclear reactor. After depositing Pd and Si onto activated single-crystal silicon substrates, Pd2Si was formed with about equal amounts of radioactive and nonradioactive Si during heating at 400 °C for 5 min. After an 1-sec annealing stage (450-->500 °C in 1 h) this silicide layer, which moves to the top of the sample during SPEG, is etched off with aqua regia. From the absence of radioactive 31Si in the etch, it is concluded that SPEG takes place by a dissociation mechanism rather than by diffusion
Efisiensi Penggunaan Modal Kerja pada PT. Duta Energi Mandiri
Siti Annisa Umi Prihatini. 2014. Efficiency Working Capital At PT. Duta Energi Mandiri under the guidance of the father of LCA. Robin Jonathan as a supervisor I and mother Elfreda A. Lau as supervisor II.The problems in this study is whether the efficiency of working capital at PT. Duta Energi Mandiri in 2012 increased compared to 2011. The purpose of this study is to analyze the efficiency of working capital and working capital turnover PT. Duta Energi Mandiri in 2011 and 2012.Working capital turnover is a ratio showing the relationship between working capital to sales and show the number of sales that can be obtained for each rupiah working capital. While the efficiency of working capital management of working capital is held appropriately and required a careful planning and meticulous in order to really be used to finance the operations of the business as efficiently as possible for the sake of business development in order to produce the optimal profit. The hypothesis in this study is the decline in the efficiency of working capital at PT. Duta Energi Mandiri in 2012 compared to the period in 2011.The analytical tool used in this study is a cash turnover, accounts receivable turnover and inventory turnover, and turnover of working capital which compares net income with net working capital is current assets less current liabilities which will be known to the efficiency of working capital of the company.Based on the analysis, it appears that the cash turnover in 2011 amounted to 26.52 times greater than in 2012 reached 9.40. Turnover of receivables at PT. Duta Energi Mandiri in 2011 that is equal to 4.64 times greater than the accounts receivable turnover in 2012 is equal to 2.89 times. Inventory turnover at PT. Duta Energi Mandiri in 2011 was 184.6 times the decline in 2012 is equal to 80.5 times. Turnover of working capital in 2011 is larger by 5.38 times compared to the year 2012 amounted to 4.27 times, which means that by 2011 every US $ 1.00 of working capital could generate net sales of Rp 5.38.Based on the analysis, it can be seen that the efficiency of working capital at PT. Duta Energi Mandiri in 2011 is greater than the efficiency of working capital in 2012. Thus the hypothesis writer is a decline in the efficiency of working capital at PT. Duta Energi Mandiri in 2012 compared with the period in 2011 is unacceptable and unsubstantiated
Statistical Geometry of Packing Defects of Lattice Chain Polymer from Enumeration and Sequential Monte Carlo Method
Voids exist in proteins as packing defects and are often associated with
protein functions. We study the statistical geometry of voids in
two-dimensional lattice chain polymers. We define voids as topological features
and develop a simple algorithm for their detection. For short chains, void
geometry is examined by enumerating all conformations. For long chains, the
space of void geometry is explored using sequential Monte Carlo importance
sampling and resampling techniques. We characterize the relationship of
geometric properties of voids with chain length, including probability of void
formation, expected number of voids, void size, and wall size of voids. We
formalize the concept of packing density for lattice polymers, and further
study the relationship between packing density and compactness, two parameters
frequently used to describe protein packing. We find that both fully extended
and maximally compact polymers have the highest packing density, but polymers
with intermediate compactness have low packing density. To study the
conformational entropic effects of void formation, we characterize the
conformation reduction factor of void formation and found that there are strong
end-effect. Voids are more likely to form at the chain end. The critical
exponent of end-effect is twice as large as that of self-contacting loop
formation when existence of voids is not required. We also briefly discuss the
sequential Monte Carlo sampling and resampling techniques used in this study.Comment: 29 pages, including 12 figure
Wake analysis for supersonic decelerator applications. Volume 2 - Application of gas-hydraulic analogy to shallow-water tow channel results
Shallow water tow channel used to study two dimensional compressible wake of supersonic decelerato
Query Expansion of Zero-Hit Subject Searches: Using a Thesaurus in Conjunction with NLP Techniques
The focus of our study is zero-hit queries in keyword subject searches and the effort of increasing recall in these cases by reformulating and, then, expanding the initial queries using an external source of knowledge, namely a thesaurus. To this end, the objectives of this study are twofold. First, we perform the mapping of query terms to the thesaurus terms. Second, we use the matched terms to expand the user’s initial query by taking advantage of the thesaurus relations and implementing natural language processing (NLP) techniques. We report on the overall procedure and elaborate on key points and considerations of each step of the process
Wake analysis for supersonic decelerator applications. Volume 1 - Theoretical analysis and correlation of wind-tunnel and shallow-water tow channel results
Wake analysis and correlation of wind tunnel and shallow water tow channel dat
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