Neanderthal selective hunting of reindeer? The case study of Abri du Maras (south-eastern France)

Fieldwork was supported by the Regional Office of Archaeology Rhône-Alpes, the French Ministry of Culture and Communication and the Ardèche Department through several scientific programs. M.G.Chacon, F. Rivals and E. Allué research are funded by ‘CERCA Programme/Generalitat de Catalunya’. Thanks to Jean-Jacques Hublin, Annabell Reiner and Steven Steinbrenner from the Max Planck Institute (MPI-EVA) for analytical support (isotope analysis). We are grateful to the two anonymous reviewers for their constructive remarks on this manuscript. The English manuscript was edited by L. Byrne, an official translator and native English speaker.Peer reviewedPostprin

Physical training in boys with Duchenne Muscular Dystrophy: the protocol of the No Use is Disuse study

Contains fulltext : 89740.pdf (publisher's version ) (Open Access)BACKGROUND: "Use it or lose it" is a well known saying which is applicable to boys with Duchenne Muscular Dystrophy (DMD). Besides the direct effects of the muscular dystrophy, the increasing effort to perform activities, the fear of falling and the use of personal aids indirectly impair leg and arm functions as a result of disuse. Physical training could oppose this secondary physical deterioration. The No Use is Disuse (NUD) study is the first study in human subjects with DMD that will examine whether a low-intensity physical training is beneficial in terms of preservation of muscle endurance and functional abilities. The study consists of two training intervention studies: study 1 "Dynamic leg and arm training for ambulant and recently wheelchair-dependent boys with DMD and, study 2 "Functional training with arm support for boys with DMD who have been confined to a wheelchair for several years". This paper describes the hypotheses and methods of the NUD study. METHODS: Study 1 is an explorative randomized controlled trial with multiple baseline measurements. Thirty boys with a DNA-established diagnosis of DMD will be included. The intervention consists of a six-months physical training during which boys train their legs and arms with active and/or assisted cycling training equipment. The primary study outcomes are muscle endurance and functional abilities, assessed with a Six-Minute Bicycle Test and the Motor Function Measure. Study 2 has a within-group repeated measurements design and will include ten boys with DMD who have already been confined to a wheelchair for several years. The six-months physical training program consists of 1) a computer-assisted training and 2) a functional training with an arm support. The primary study outcome is functional abilities of the upper extremity, assessed with the Action Research Arm Test. DISCUSSION: The NUD study will fill part of the gap in the current knowledge about the possible effects of training in boys with DMD and will increase insight into what type of exercise should be recommended to boys with DMD. The study will finish at the end of 2010 and results are expected in 2011. TRIAL REGISTRATION: The Netherlands National Trial Register1631

Le site du Ranc-Pointu no. 2 à Saint-Martin-d’Ardèche : Une occupation du Paléolithique moyen ancien dans le Sud-Est de la France = The site of Ranc-Pointu No. 2 at Saint-Martin-d’Ardèche: An early Middle Palaeolithic occupation in southeastern France?

International audienc

Onychomycosis: Beyond cosmetic distress

Onychomycosis, or fungal infection of the nail, is the most common nail disease affecting children (although to a lesser extent) as well as adults. The distress it provokes is not only of a cosmetic kind; it may impair the quality of life. The different clinical types of onychomycos is should be differentiated from similar-looking nail diseases. As far as therapy is concerned, the appearance of new antifungal drugs in the 1990s makes our job easier, but it does not allow us to cure 100% of the patients. Relapses still exist. The aim of this article is to help dermatologists achieve a tail or-made treatment for their patients. The clinical type, the compulsory mycological investigations, the age of the patient, his medical history (drug intake), as well as the use of nail cosmetics, must be considered. © 2006 Blackwell Publishing.SCOPUS: ar.jFLWINinfo:eu-repo/semantics/publishe