Tourism locating procedures through the examples of Jász-Nagykun-Szolnok county subregions

The secondary research on rural sub-regional tourism is investigating the determining factors and the relationships between them. The analysis concentrates on the tourism potential of rural sub-regions and the performance of tourism. We used the method of discriminant analysis for classifying observations into two or more groups based on the specified predictors. Output includes the classification matrix, the squared distance between group centers, the linear discriminant function, means standard deviations, covariance matrices, and a summary of how each observation was classified. After that, we have classified rural sub-regions according to their strategies of tourism development. The strategy of development for sub-regions belonging to the same group should be the same. This classification can be a useful basis for the conceptions of rural development and development of tourism.tourism, rural development, locating procedure, development position, Agricultural and Food Policy,

A hazai zöldségtermelés megújítása

Az éghajlatváltozás hatásai a minÅ‘ségi termelés követelményei, a rentábilis termelés igénye, a termeléstechnológiai elemek megújításának, korszerűsítésének szükségessége egyaránt sürgetik a fenti követelményeket szem elÅ‘tt tartó, annak megfelelni akaró módszert, a szabadföldi intenzív termelést, melynek legfontosabb elemei: az idÅ‘szakos talaj-, növény- és légtértakarás, a víztakarékos öntözési módok alkalmazása és a retardált műtrágya használata. Az idÅ‘szakos talaj-, növény- és légtértakarással a szedési idÅ‘szak meghosszabbítható, és egyúttal javítható a talaj vízgazdálkodása, valamint visszaszorítható a gyomosodás. A mikroöntözés alkalmazásával, azonos vízmennyiséggel kétszer akkora terület öntözhetÅ‘. Retardált (fékezett lebomlású) műtrágyák használatával jobb növénytápláltság érhetÅ‘ el, és az esetek többségében a fejtrágyázás is feleslegessé válik. Célszerű létrehozni mielÅ‘bb egy kiváló nyersanyagokból kiváló minÅ‘ségű, jellegzetesen magyar termékeket gyártó feldolgozóipart, amelynek kínálatában a funkcionális (pharma) termékek is megjelennek. Eközben arról sem szabad megfeledkezni, hogy jó minÅ‘ségű konzerv csak jó minÅ‘ségű nyersanyagból készíthetÅ‘! ------------------------------------------------------------ The climate is changing, and we have to adapt to it. The possible methods of compliance include temporary soil, plant and air covering, water economical irrigation, and the ap¬plication of retardable fertilizers. Temporary soil, plant and air covering with plastic sheets is a method applied most¬ly under temperate climatic conditions. Its key purpose is to enable earlier harvest and to lengthen the picking period. The use of economical irrigation methods can double the area which can be irrigated with the same amount of water. The application of retardable fertilizers can ensure harmonious plant nutrition without top dressing. The renewal of the Hungarian canning industry is an urgent task. The development of vegetable production is unthinkable without valuable canning products.zöldségtermelés, feldolgozóipar, speciális készítmények, tájtermelés, intenzív termesztés, vegetable production, territory, assortment, canning industry, special products, growing regions, intensity, Crop Production/Industries, Farm Management,

Altered regulation of Prox1-gene-expression in liver tumors

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Canagliflozin and Cardiovascular and Renal Outcomes in Type 2 Diabetes Mellitus and Chronic Kidney Disease in Primary and Secondary Cardiovascular Prevention Groups

Background: Canagliflozin reduces the risk of kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, but effects on specific cardiovascular outcomes are uncertain, as are effects in people without previous cardiovascular disease (primary prevention). Methods: In CREDENCE (Canagliflozin and Renal Events in Diabetes With Established Nephropathy Clinical Evaluation), 4401 participants with type 2 diabetes mellitus and chronic kidney disease were randomly assigned to canagliflozin or placebo on a background of optimized standard of care. Results: Primary prevention participants (n=2181, 49.6%) were younger (61 versus 65 years), were more often female (37% versus 31%), and had shorter duration of diabetes mellitus (15 years versus 16 years) compared with secondary prevention participants (n=2220, 50.4%). Canagliflozin reduced the risk of major cardiovascular events overall (hazard ratio [HR], 0.80 [95% CI, 0.67-0.95]; P=0.01), with consistent reductions in both the primary (HR, 0.68 [95% CI, 0.49-0.94]) and secondary (HR, 0.85 [95% CI, 0.69-1.06]) prevention groups (P for interaction=0.25). Effects were also similar for the components of the composite including cardiovascular death (HR, 0.78 [95% CI, 0.61-1.00]), nonfatal myocardial infarction (HR, 0.81 [95% CI, 0.59-1.10]), and nonfatal stroke (HR, 0.80 [95% CI, 0.56-1.15]). The risk of the primary composite renal outcome and the composite of cardiovascular death or hospitalization for heart failure were also consistently reduced in both the primary and secondary prevention groups (P for interaction >0.5 for each outcome). Conclusions: Canagliflozin significantly reduced major cardiovascular events and kidney failure in patients with type 2 diabetes mellitus and chronic kidney disease, including in participants who did not have previous cardiovascular disease

Canagliflozin and renal outcomes in type 2 diabetes and nephropathy

BACKGROUND Type 2 diabetes mellitus is the leading cause of kidney failure worldwide, but few effective long-term treatments are available. In cardiovascular trials of inhibitors of sodium–glucose cotransporter 2 (SGLT2), exploratory results have suggested that such drugs may improve renal outcomes in patients with type 2 diabetes. METHODS In this double-blind, randomized trial, we assigned patients with type 2 diabetes and albuminuric chronic kidney disease to receive canagliflozin, an oral SGLT2 inhibitor, at a dose of 100 mg daily or placebo. All the patients had an estimated glomerular filtration rate (GFR) of 30 to <90 ml per minute per 1.73 m2 of body-surface area and albuminuria (ratio of albumin [mg] to creatinine [g], >300 to 5000) and were treated with renin–angiotensin system blockade. The primary outcome was a composite of end-stage kidney disease (dialysis, transplantation, or a sustained estimated GFR of <15 ml per minute per 1.73 m2), a doubling of the serum creatinine level, or death from renal or cardiovascular causes. Prespecified secondary outcomes were tested hierarchically. RESULTS The trial was stopped early after a planned interim analysis on the recommendation of the data and safety monitoring committee. At that time, 4401 patients had undergone randomization, with a median follow-up of 2.62 years. The relative risk of the primary outcome was 30% lower in the canagliflozin group than in the placebo group, with event rates of 43.2 and 61.2 per 1000 patient-years, respectively (hazard ratio, 0.70; 95% confidence interval [CI], 0.59 to 0.82; P=0.00001). The relative risk of the renal-specific composite of end-stage kidney disease, a doubling of the creatinine level, or death from renal causes was lower by 34% (hazard ratio, 0.66; 95% CI, 0.53 to 0.81; P<0.001), and the relative risk of end-stage kidney disease was lower by 32% (hazard ratio, 0.68; 95% CI, 0.54 to 0.86; P=0.002). The canagliflozin group also had a lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80; 95% CI, 0.67 to 0.95; P=0.01) and hospitalization for heart failure (hazard ratio, 0.61; 95% CI, 0.47 to 0.80; P<0.001). There were no significant differences in rates of amputation or fracture. CONCLUSIONS In patients with type 2 diabetes and kidney disease, the risk of kidney failure and cardiovascular events was lower in the canagliflozin group than in the placebo group at a median follow-up of 2.62 years

Tourism locating procedures through the examples of Jász-Nagykun-Szolnok county subregions

The secondary research on rural sub-regional tourism is investigating the determining factors and the relationships between them. The analysis concentrates on the tourism potential of rural sub-regions and the performance of tourism. We used the method of discriminant analysis for classifying observations into two or more groups based on the specified predictors. Output includes the classification matrix, the squared distance between group centers, the linear discriminant function, means standard deviations, covariance matrices, and a summary of how each observation was classified. After that, we have classified rural sub-regions according to their strategies of tourism development. The strategy of development for sub-regions belonging to the same group should be the same. This classification can be a useful basis for the conceptions of rural development and development of tourism

A hazai zöldségtermelés megújítása

Az éghajlatváltozás hatásai a minőségi termelés követelményei, a rentábilis termelés igénye, a termeléstechnológiai elemek megújításának, korszerűsítésének szükségessége egyaránt sürgetik a fenti követelményeket szem előtt tartó, annak megfelelni akaró módszert, a szabadföldi intenzív termelést, melynek legfontosabb elemei: az időszakos talaj-, növény- és légtértakarás, a víztakarékos öntözési módok alkalmazása és a retardált műtrágya használata. Az időszakos talaj-, növény- és légtértakarással a szedési időszak meghosszabbítható, és egyúttal javítható a talaj vízgazdálkodása, valamint visszaszorítható a gyomosodás. A mikroöntözés alkalmazásával, azonos vízmennyiséggel kétszer akkora terület öntözhető. Retardált (fékezett lebomlású) műtrágyák használatával jobb növénytápláltság érhető el, és az esetek többségében a fejtrágyázás is feleslegessé válik. Célszerű létrehozni mielőbb egy kiváló nyersanyagokból kiváló minőségű, jellegzetesen magyar termékeket gyártó feldolgozóipart, amelynek kínálatában a funkcionális (pharma) termékek is megjelennek. Eközben arról sem szabad megfeledkezni, hogy jó minőségű konzerv csak jó minőségű nyersanyagból készíthető! ------------------------------------------------------------ The climate is changing, and we have to adapt to it. The possible methods of compliance include temporary soil, plant and air covering, water economical irrigation, and the ap¬plication of retardable fertilizers. Temporary soil, plant and air covering with plastic sheets is a method applied most¬ly under temperate climatic conditions. Its key purpose is to enable earlier harvest and to lengthen the picking period. The use of economical irrigation methods can double the area which can be irrigated with the same amount of water. The application of retardable fertilizers can ensure harmonious plant nutrition without top dressing. The renewal of the Hungarian canning industry is an urgent task. The development of vegetable production is unthinkable without valuable canning products