43 research outputs found
Hydrazones as Singular Reagents in Asymmetric Organocatalysis
This Minireview summarizes strategies and developments regarding the use of hydrazones as reagents in asymmetric organocatalysis, their distinct roles in nucleophile–electrophile, cycloaddition, and cyclization reactions. The key structural elements governing the reactivity of these reagents in a preferred pathway will be discussed, as well as their different interactions with organocatalysts, leading to diverse activation modes. Along these studies, the synthetic equivalence of N-monoalkyl, N,N-dialkyl, and N-acyl hydrazones with several synthons is also highlighted. Emphasis is also put on the mechanistic studies performed to understand the observed reactivities. Finally, the functional group transformations performed from the available products has also been analyzed, highlighting the synthetic value of these methodologies, which served to access numerous families of valuable multifunctional compounds and nitrogen-containing heterocycles.Ministerio de Economía y Competitividad CTQ2013-48164-C2-1-P, CTQ201348164-C2-2-PEuropean FEDER fundsJunta de Andalucía 2012/FQM 107
Hydrazones as Singular Reagents in Asymmetric Organocatalysis
This Minireview summarizes strategies and developments regarding the use of hydrazones as reagents in asymmetric organocatalysis, their distinct roles in nucleophile–electrophile, cycloaddition, and cyclization reactions. The key structural elements governing the reactivity of these reagents in a preferred pathway will be discussed, as well as their different interactions with organocatalysts, leading to diverse activation modes. Along these studies, the synthetic equivalence of N-monoalkyl, N,N-dialkyl, and N-acyl hydrazones with several synthons is also highlighted. Emphasis is also put on the mechanistic studies performed to understand the observed reactivities. Finally, the functional group transformations performed from the available products has also been analyzed, highlighting the synthetic value of these methodologies, which served to access numerous families of valuable multifunctional compounds and nitrogen-containing heterocycles.Peer Reviewe
Room Temperature Ionic Liquids in Asymmetric Hetero-Ene Type Reactions: Improving Organocatalyst Performance at Lower Temperatures
Abstract: Room temperature ionic liquids (RTILs) have been widely used as (co)solvents in several
catalytic processes modifying, in most of the cases, the catalyst activity and/or the selectivity for
the studied reactions. However, there are just a few examples of their use in hydrogen bonding
organocatalysis. In this paper, we show the positive effect of a set of imidazole-based ionic liquids
([bmim]BF4 and [hmim]PF6
) in the enantioselective addition of formaldehyde tert-butylhydrazone
to prochiral α-keto esters catalyzed by a sugar-based chiral thiourea. Reactions performed in the
presence of low percentages of RTILs led to an increase of the catalyst activity, thereby making
possible to work at lower temperatures. Thus, the chiral tert-butyl azomethyl tertiary alcohols could
be obtained with moderate to good conversions and higher enantioselectivities for most of the studied
substrates when using up to 30 vol% of [hmim]PF6 as a cosolvent in processes performed in toluene.Ministerio de Economia, Industria y Competitividad del gobierno español-CTQ2016- 76908-C2-1-P y CTQ2016- 76908-C2-2-PFondos europeos FEDER y Junta de Andalucía- Beca P18-FR-353
Synthesis of enantioenriched azo compounds: Organocatalytic Michael addition of formaldehyde N-tert-butyl hydrazone to nitroalkenes
The unprecedented diaza-ene reaction of formaldehyde N-tert-butyl hydrazone with nitroalkenes can be efficiently catalyzed by an axially chiral bis-thiourea to afford the corresponding diazenes in good to excellent yields (60-96%) and moderate enantioselectivities, up to 84 : 16 er; additional transformation of diazenes into their tautomeric hydrazones proved to be operationally simple and high-yielding, affording bifunctional compounds which represent useful intermediates for the synthesis of enantioenriched β-nitro-nitriles and derivatives thereof.Ministerio de Ciencia e Innovación CTQ2010-15297, CTQ2010-14974Junta de Andalucía 2008/ FQM-3833, 2009/FQM-453
Design and synthesis of new bis-hydrazones and pyridine bis-hydrazones: application in the asymmetric Diels-Alder reaction
Formaldehyde tert-butyl hydrazone as a formyl anion equivalent: asymmetric addition to carbonyl compounds
The asymmetric 1,2-addition of formyl anion equivalents to carbonyl compounds is a powerful synthetic
tool that ideally provide access to highly functionalizable a-hydroxy aldehydes in an enantioselective fashion.
In this context, the nucleophilic character of formaldehyde hydrazones, together with their remarkable
stability as monomeric species, has been exploited for the functionalization of diverse carbonyl compounds,
using initially auxiliary-based methodologies and, more recently, catalytic enantioselective versions. This
feature article highlights our research progress employing formaldehyde tert-butyl hydrazone as a versatile
formyl anion equivalent, in combination with bifunctional H-bonding organocatalysis. The design and
optimization of different catalytic systems, focusing on a dual activation of both reagents, is reviewed, as
well as the racemization free unmasking of the formyl group and representative product transformations for
the construction of valuable, densely functionalyzed chiral building blocks.Ministerio de Economía y Competitividad de España (MINECO).CTQ2016-76908-C2-1-P y CTQ2016-76908-C2-2-PFondos FEDER de la Unión Europea y Junta de Andalucía. P18-FR-3531 y US126286
Stroke: roles of B vitamins, homocysteine and antioxidants
19 páginas, 1 figura, 2 tablas.In the present review concerning stroke, we evaluate the roles of B vitamins, homocysteine and antioxidant vitamins. Stroke is a leading cause of death in developed countries. However, current therapeutic strategies for stroke have been largely unsuccessful. Several studies have reported important benefits on reducing the risk of stroke and improving the post-stroke-associated functional declines in patients who ate foods rich in micronutrients, including B vitamins and antioxidant vitamins E and C. Folic acid, vitamin B6 and vitamin B12 are all cofactors in homocysteine metabolism. Growing interest has been paid to hyperhomocysteinaemia as a risk factor for CVD. Hyperhomocysteinaemia has been linked to inadequate intake of vitamins, particularly to B-group vitamins and therefore may be amenable to nutritional intervention. Hence, poor dietary intake of folate, vitamin B6 and vitamin B12 are associated with increased risk of stroke. Elevated consumption of fruits and vegetables appears to protect against stroke. Antioxidant nutrients have important roles in cell function and have been implicated in processes associated with ageing, including vascular, inflammatory and neurological damage. Plasma vitamin E and C concentrations may serve as a biological marker of lifestyle or other factors associated with reduced stroke risk and may be useful in identifying those at high risk of stroke. After reviewing the observational and intervention studies, there is an incomplete understanding of mechanisms and some conflicting findings; therefore the available evidence is insufficient to recommend the routine use of B vitamins, vitamin E and vitamin C for the prevention of stroke. A better understanding of mechanisms, along with well-designed controlled clinical trials will allow further progress in this area.Peer reviewe
Chirality and catalysis with aromatic N-fused heterobicyclic carbenes
The benzoannulation of the most common families of aromatic NHCs, imidazol-2-ylidenes and 1,2,4-triazol-3-ylidenes, results in heterobicyclic imidazo[1,5-a]pyridin-3-ylidenes (ImPy's) and [1,2,4]triazolo[4,3-a]pyridin-3-ylidenes (TriPy's), characterized by a bridged N atom. These are versatile platforms that offer multiple possibilities for the modulation of the steric and electronic properties of the carbene ligand and/or organocatalyst, and offer also diverse opportunities for the introduction of several types of chiralities. In this paper the different families of chiral ImPy and TriPy carbenes and their application in asymmetric catalysis will be discussed.España, Ministerio de Economía y Competitividad (CTQ2013-48164-C2-1-P, CTQ2013- 48164-C2-2-P, and predoctoral fellowship to C. I.),España Junta de Andalucía (Grant 2012/FQM 1078
Studies on the Synthesis of 2-Alkyl-5-aryl-1,3,4-oxadiazolines from N-Acylhydrazones
Reaction of N-acylhydrazones with benzyloxyacetyl chloride in the presence of i-Pr 2EtN affords new 1,3,4-oxadiazolines in excellent yields (72-95%), under mild reaction conditions and in short reaction times. The structures of the products were confirmed by single-crystal X-ray diffractometry. A plausible reaction mechanism is proposedMinisterio de Ciencia e Innovación CTQ2010-15297, CTQ2010-14974Junta de Andalucía 2008/ FQM-3833, 2009/FQM-453
Asymmetric Organocatalytic Synthesis of Fluorinated β-Hydroxy Diazenes
The nucleophilic addition of formaldehyde tert-butyl hydrazone to fluoromethyl ketones provides a valuable tool for the synthesis of highly functionalized β-hydroxy β-tri- and difluoromethyl diazenes. Excellent reactivities and moderate to good enantioselectivities (up to 90 % ee) were achieved by H-bonding activation exerted by tert-Leucine derived H-bonding (squaramide or thiourea) organocatalysts. Subsequent derivatizations in one-pot fashion provide synthetically useful intermediates for target-oriented synthesis: tri- and di-fluoromethylated azoxy compounds, β-amino alcohols, α-hydroxy aldoximes and derivatives thereof.Ministerio de Economía y Competitividad CTQ2016-76908-C2-1-P, CTQ2016-76908-C2-2-PJunta de Andalucía 2012/FQM107