Pembinaan Bacaan dan Gerakan Sholat

Al-Qur\u27an sebagai suatu mukjizat tidak hanya menjadi bahan bacaan meskipun membacanya akan mendapat pahala, melainkan juga untuk difahami, dihayati, dipedomani, diamalkan dan diselidiki rahasia kebanarannya. Pelaksanaan pembinaan Bacaan al-Qur\u27an dilakukan dengan menggunakan metode sorongan yaitu siswa membaca didepan pelatih yang menjadi pengajar dan menyimaknya. Adapun yang menjadi problem dalam pengajaran Baca Tulis al-Qur\u27an (BTQ) adalah semua komponen pengajaran itu sendiri meliputi materi yang kurang lengkap, kompetensi pengajar kurang, perbedaan kecerdasan peserta, kurangnya media pengajaran. Kegiatan ini dilaksanakan dengan tahapan-tahapan berikut; 1) elatihan bacaan Al-Qur\u27an, 2) praktek membimbing tata cara shalat dan berwudhu, dan 3) proses belajar mengajar melalui media tulis dan keterampilan. Adapun upaya yang ditempuh dalam pengajaran Baca Tulis al-Qur\u27an meliputi berusaha melengkapi sarana prasarana menggunakan metode yang bervariasi

Autistic group differences in naturalistic social attention are magnified by perceptual load

Differences in both social and sensory processing are well described in the autism literature, but little is known about the causal relationship between these domains, particularly in real-world environments. In the present study, we sought to understand how a core characteristic of the autistic phenotype – reduced social attention – is impacted by the complex multisensory signals present in environments like those encountered in daily life. We tested the hypothesis that autistic group differences in social attention would be magnified by increasing perceptual load (e.g., motion, multisensory cues). Adult participants (N = 40; 19 ASC) explored a diverse set of 360° real-world scenes in a naturalistic, active viewing paradigm (immersive virtual reality + eyetracking). Across three conditions, we systematically varied perceptual load while holding the social and semantic information present in each scene constant. We demonstrate that group differences in social attention are not a static signature of the autistic phenotype; rather, they emerge with increasing perceptual load in naturalistic environments. Crucially, this pattern was specific to the social domain and not driven by low-level oculomotor differences: we did not observe differential impacts of perceptual load on attention directed toward nonsocial semantic (i.e., object, place) information or fixation behavior. This study provides a direct link between social and sensory processing in autism. Moreover, reduced social attention may be an inaccurate characterization of autism. Instead, our results suggest that social attention in autism is better explained by “social vulnerability", particularly to the perceptual load of real-world environments

A comparison of the growth and starvation responses of Acanthamoeba castellanii and Hartmannella vermiformis in the presence of suspended and attached Escherichia coli K12

The growth and starvation responses of Acanthamoeba castellanii and Hartmannella vermiformis were investigated in the presence and absence of Escherichia coli on an agar surface or within shaken suspensions. The amoebae perceived all the suspended systems to be unfavourable for growth, despite being challenged with high levels of prey, and as a consequence they exhibited a starvation response. However, the response differed between species, with A. castellanii producing characteristic cysts and H. vermiformis producing round bodies. These amoebic forms were reactivated into feeding trophozoites in the presence of bacterial aggregates, which formed in the suspended systems after 68 h of incubation. In contrast, both species of amoebae grew well in the presence of attached E. coli at a concentration of 1 × 106 cells cm2 of agar and yielded specific growth rates of c. 0.04 h1. Starvation responses were induced at the end of the growth phase, and these were equivalent to those recorded in the suspended systems. We conclude that, when suspended, amoebae in the ‘floating form’ cannot feed effectively on suspended prey, and hence the starvation response is initiated. Thus the majority of amoebic feeding is via trophozoite grazing of attached bacterial prey

Neutralizing Gatad2a-Chd4-Mbd3/NuRD Complex Facilitates Deterministic Induction of Naive Pluripotency

Mbd3, a member of nucleosome remodeling and deacetylase (NuRD) co-repressor complex, was previously identified as an inhibitor for deterministic induced pluripotent stem cell (iPSC) reprogramming, where up to 100% of donor cells successfully complete the process. NuRD can assume multiple mutually exclusive conformations, and it remains unclear whether this deterministic phenotype can be attributed to a specific Mbd3/NuRD subcomplex. More-over, since complete ablation of Mbd3 blocks somatic cell proliferation, we aimed to explore functionally relevant alternative ways to neutralize Mbd3-dependent NuRD activity. We identify Gatad2a, a NuRD-specific subunit, whose complete deletion specifically disrupts Mbd3/NuRD repressive activity on the pluripotency circuitry during iPSC differentiation and reprogramming without ablating somatic cell proliferation. Inhibition of Gatad2a facilitates deterministic murine iPSC reprogramming within 8 days. We validate a distinct molecular axis, Gatad2a-Chd4-Mbd3, within Mbd3/NuRD as being critical for blocking reestablishment of naive pluripotency and further highlight signaling-dependent and post-translational modifications of Mbd3/NuRD that influence its interactions and assembly