Inflammatory placental lesions are specifically observed in healthy oocyte donation pregnancies with extreme fetal-maternal incompatibility

Introduction: Oocyte donation (OD) pregnancy is a risk factor for pre-eclampsia (PE). Due to a higher extent of fetal-maternal human leukocyte antigens (HLA) mismatching in OD pregnancies compared to naturally conceived (NC) and in vitro fertilization (IVF) pregnancies, the immune response in OD placentas is probably divergent and affects clinical outcomes. We hypothesized that placental pathology varies among diverse pregnancy conditions and is related to fetal-maternal HLA incompatibility. Methods: Placental lesions were scored in four patient groups: OD-PE (n = 16), OD-healthy (n = 37), NC-PE (n = 45), and IVF-healthy (n = 17). All combinations were genotyped for HLA-A, -B, -C, -DR, and -DQ to calculate fetal-maternal HLA mismatches. Placentas showing chronic deciduitis with plasma cells were immunofluorescently stained with CD138 and the anti-inflammatory cytokine interleukin-10 (IL-10).Results: The distribution and severity of placental lesions varied among groups. The OD-healthy group had the highest inflammation score and greatest extent of chronic deciduitis with plasma cells (p &lt; 0.05). However, the majority of CD138+ plasma cells (90%) in OD-healthy group expressed IL-10, in contrast to the OD-PE group (58%). The OD-healthy group was separated into semi-allogeneic (≤5 HLA mismatches) and fully allogeneic (&gt;5 mismatches) subgroups. The elevated inflammatory pathology score and chronic deciduitis with plasma cells were found more often in the HLA-class-I fully allogeneic OD-healthy group than the IVF-healthy group (p &lt; 0.05). Discussion: Placental inflammatory lesions are most often present in uncomplicated OD pregnancies. Immune cells that infiltrate these lesions might play an immunosuppressive role to protect OD pregnancies from complications when facing a higher extent of fetal-maternal HLA mismatching.</p

Amyloid polymorphisms constitute distinct clouds of conformational variants in different etiological subtypes of Alzheimer's disease

The molecular architecture of amyloids formed in vivo can be interrogated using luminescent conjugated oligothiophenes (LCOs), a unique class of amyloid dyes. When bound to amyloid, LCOs yield fluorescence emission spectra that reflect the 3D structure of the protein aggregates. Given that synthetic amyloid-β peptide (Aβ) has been shown to adopt distinct structural conformations with different biological activities, we asked whether Aβ can assume structurally and functionally distinct conformations within the brain. To this end, we analyzed the LCO-stained cores of β-amyloid plaques in postmortem tissue sections from frontal, temporal, and occipital neocortices in 40 cases of familial Alzheimer's disease (AD) or sporadic (idiopathic) AD (sAD). The spectral attributes of LCO-bound plaques varied markedly in the brain, but the mean spectral properties of the amyloid cores were generally similar in all three cortical regions of individual patients. Remarkably, the LCO amyloid spectra differed significantly among some of the familial and sAD subtypes, and between typical patients with sAD and those with posterior cortical atrophy AD. Neither the amount of Aβ nor its protease resistance correlated with LCO spectral properties. LCO spectral amyloid phenotypes could be partially conveyed to Aβ plaques induced by experimental transmission in a mouse model. These findings indicate that polymorphic Aβ-amyloid deposits within the brain cluster as clouds of conformational variants in different AD cases. Heterogeneity in the molecular architecture of pathogenic Aβ among individuals and in etiologically distinct subtypes of AD justifies further studies to assess putative links between Aβ conformation and clinical phenotype

Demographics of Aging

Excerpt The experience of growing older in the 21st century is vastly different from the past. The advancement in technology, medicine, and lower rates of death at birth has allowed for the population to shift in size. The shift is specifically from the baby boomers generation, which refers to the increase in birth rate from 1940’s to the early 1960’s. This generation is aging and in recent years the first baby boomers began reaching retirement age. This segment of the U.S. is the fastest growing, so it is essential to understand the growth of the aging population. This aging group is divided due to its immense diversity

Stereotype Thinking

Excerpt Stereotypes are widely held fixed thoughts and beliefs adopted by common members of a group, that represent a particular group of individuals or behaviors as a whole. Attitudes people hold reflect in-group beliefs, values, and everyday life choices that are transgressed throughout multiple generations. Stereotypes are intertwined into society, and although many people would like to deny these attitudes, they are implanted on individuals when we are young and occur without conscious awareness. Stereotype thinking is adaptive in nature, which serves the purpose to help people make sense of the world around them, by explaining social events, justifying one’s actions, and assists to distinguish in-groups in a more positive light from out-groups. Stereotype thinking permits people to have the capability of understanding others and simultaneously shapes the way individuals encounter situations

Forensic Neuropsychological Evaluation of the Violent Offender

V, 57 p.online resource

Complex Emotions

Excerpt Complex emotions are ways in which an individual reacts and respond to complex social situations when encountering people and situations in the social world. Thus, complex emotions are ways of coping and adapting to complex social situations. Complex emotions are mental representations that have been studied on a three-level analysis surrounding the body, mind, and society, which translates to the biological and the evolutionary, the mental and the psychological, and the social and the cultural. This approach has been referred to as the neurocognitive sociology of emotions

Mental Models in Children

Excerpt Researchers in the area of child psychology have taken an interest in how children revise their understanding of the world. Stella Vosniadou and William Brewer (1991) postulated a theory called mental models, which provides insight into how genuine understanding is attained. The postulated mental models are created and then tested to build up one’s understanding of how the world works. Additionally, this theory implies there may be points in time where there is some understanding of a concept, yet it is still incomplete. Vosniadou and Brewer wanted to explore these intermediate mental models and develop evidence of understanding in progress. Experimen

Social Groups and Development

Excerpt Children spend an increasing amount of time in social groups as they age. Preschoolers begin to interact with their peers around playsets, though at this stage, these early social groups are loosely organized. It is not until they reach school age that children begin to feel as true members of a peer group. A peer group interacts on a regular basis, provides a sense of belonging, has implicit or explicit norms, and has a hierarchical order. Within these groups, social status becomes important, with some members being more popular and having a greater social impact than others

Newborn Reflexes

Excerpt Reflexes are characterized as involuntary movements or actions and are a key indicator of a healthy brain and nervous system in newborn babies. There are five primitive reflexes that are common for infants who do not experience central nervous system (CNS) deficits. Furthermore, newborn reflexes are also considered to add adaptive value by increasing their chances of survival