A Single Visualization Technique for Displaying Multiple Metabolite-Phenotype Associations.

To assist with management and interpretation of human metabolomics data, which are rapidly increasing in quantity and complexity, we need better visualization tools. Using a dataset of several hundred metabolite measures profiled in a cohort of ~1500 individuals sampled from a population-based community study, we performed association analyses with eight demographic and clinical traits and outcomes. We compared frequently used existing graphical approaches with a novel 'rain plot' approach to display the results of these analyses. The 'rain plot' combines features of a raindrop plot and a conventional heatmap to convey results of multiple association analyses. A rain plot can simultaneously indicate effect size, directionality, and statistical significance of associations between metabolites and several traits. This approach enables visual comparison features of all metabolites examined with a given trait. The rain plot extends prior approaches and offers complementary information for data interpretation. Additional work is needed in data visualizations for metabolomics to assist investigators in the process of understanding and convey large-scale analysis results effectively, feasibly, and practically

Can residuals of the Solar system foreground explain low multipole anomalies of the CMB ?

The low multipole anomalies of the Cosmic Microwave Background has received much attention during the last few years. It is still not ascertained whether these anomalies are indeed primordial or the result of systematics or foregrounds. An example of a foreground, which could generate some non-Gaussian and statistically anisotropic features at low multipole range, is the very symmetric Kuiper Belt in the outer solar system. In this paper, expanding upon the methods presented by Maris et al. (2011), we investigate the contributions from the Kuiper Belt objects (KBO) to the WMAP ILC 7 map, whereby we can minimize the contrast in power between even and odd multipoles in the CMB, discussed discussed by Kim & Naselsky (2010). We submit our KBO de-correlated CMB signal to several tests, to analyze its validity, and find that incorporation of the KBO emission can decrease the quadrupole-octupole alignment and parity asymmetry problems, provided that the KBO signals has a non-cosmological dipole modulation, associated with the statistical anisotropy of the ILC 7 map. Additionally, we show that the amplitude of the dipole modulation, within a 2 sigma interval, is in agreement with the corresponding amplitudes, discussed by Lew (2008).Comment: 24 pages, 9 figures, 5 tables. Matches version in JCA

Massive Star Cluster Formation and Destruction in Luminous Infrared Galaxies in GOALS

We present the results of a {\it Hubble Space Telescope} ACS/HRC FUV, ACS/WFC optical study into the cluster populations of a sample of 22 Luminous Infrared Galaxies in the Great Observatories All-Sky LIRG Survey. Through integrated broadband photometry we have derived ages and masses for a total of 484 star clusters contained within these systems. This allows us to examine the properties of star clusters found in the extreme environments of LIRGs relative to lower luminosity star-forming galaxies in the local Universe. We find that by adopting a Bruzual \& Charlot simple stellar population (SSP) model and Salpeter initial mass function, the age distribution of clusters declines as $dN/d\tau = \tau^{-0.9 +/- 0.3}$, consistent with the age distribution derived for the Antennae Galaxies, and interpreted as evidence for rapid cluster disruption occuring in the strong tidal fields of merging galaxies. The large number of $10^{6} M_{\odot}$ young clusters identified in the sample also suggests that LIRGs are capable of producing more high-mass clusters than what is observed to date in any lower luminosity star-forming galaxy in the local Universe. The observed cluster mass distribution of $dN/dM = M^{-1.95 +/- 0.11}$ is consistent with the canonical -2 power law used to describe the underlying initial cluster mass function (ICMF) for a wide range of galactic environments. We interpret this as evidence against mass-dependent cluster disruption, which would flatten the observed CMF relative to the underlying ICMF distribution.Comment: 63 pages, 58 Figures, 56 Tables, Accepted for publication in Ap

Finite-size scaling for non-linear rheology of fluids confined in a small space

We perform molecular dynamics simulations in order to examine the rheological transition of fluids confined in a small space. By performing finite-size scaling analysis, we demonstrate that this rheological transition results from the competition between the system size and the length scale of cooperative particle motion.Comment: 4pages, 8 figure

The Lifetimes and Evolution of Molecular Cloud Cores

We discuss the lifetimes and evolution of clumps and cores formed as turbulent density fluctuations in nearly isothermal molecular clouds. In the non-magnetic case, clumps are unlikely to reach a hydrostatic state, and instead are expected to either proceed directly to collapse, or else ``rebound'' towards the mean pressure and density of the parent cloud. Rebounding clumps are delayed in their re-expansion by their self-gravity. From a simple virial calculation, we find re-expansion times of a few free-fall times. In the magnetic case, we present a series of driven-turbulence, ideal-MHD isothermal numerical simulations in which we follow the evolution of clumps and cores in relation to the magnetic criticality of their ``parent clouds'' (the numerical boxes). In subcritical boxes, magnetostatic clumps do not form. A few moderately-gravitationally bound clumps form which however are dispersed by the turbulence in < 1.3 Myr. An estimate of the ambipolar diffusion (AD) time scale t_AD in these cores gives t_AD > 1.3 Myr, only slightly longer than the dynamical times. In supercritical boxes, some cores become locally supercritical and collapse in typical times ~ 1 Myr. We also observe longer-lived supercritical cores that however do not collapse because they are smaller than the local Jeans length. Fewer clumps and cores form in these simulations than in their non-magnetic counterpart. Our results suggest that a) A fraction of the cores may not form stars, and may correspond to some of the observed starless cores. b) Cores may be out-of-equilibrium structures, rather than quasi-magnetostatic ones. c) The magnetic field may help reduce the star formation efficiency by reducing the probability of core formation, rather than by significantly delaying the collapse of individual cores.Comment: Accepted in ApJ. Originally submitted as astro-ph/0208245. Completely rewritten, now including numerical simulations. Animations available at http://www.astrosmo.unam.mx/~e.vazquez/turbulence_HP/movies/VKSB04.htm

This Is Just A Test: Overcoming High-Stakes Test Anxiety through Relaxation and Gum Chewing When Preparing for the ACT

This study was a replication of a previous study (in which) participants were given relaxation and deep breathing training to help manage test anxiety. The study examined the correlations between relaxation strategies, gum chewing and variables including socioeconomic status, class rank, GPA, and importance of going to college. Participants included 96 high school students (36 males, 60 females), preparing for the ACT (American College Testing). Results indicated that the relaxation intervention had a significant effect in reducing test anxiety

Dynamical Axion Field in Topological Magnetic Insulators

Axions are very light, very weakly interacting particles postulated more than 30 years ago in the context of the Standard Model of particle physics. Their existence could explain the missing dark matter of the universe. However, despite intensive searches, they have yet to be detected. In this work, we show that magnetic fluctuations of topological insulators couple to the electromagnetic fields exactly like the axions, and propose several experiments to detect this dynamical axion field. In particular, we show that the axion coupling enables a nonlinear modulation of the electromagnetic field, leading to attenuated total reflection. We propose a novel optical modulators device based on this principle.Comment: 5 pages, 3 figure