15 research outputs found

    Fam65b is a new transcriptional target of FOXO1 that regulates RhoA signaling for T lymphocyte migration

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    Forkhead box Os (FOXOs) transcription factors favor both T cell quiescence and trafficking through their control of the expression of genes involved in cell cycle progression, adhesion and homing. Here, we report that the product of the fam65b gene is a new transcriptional target of FOXO1 that regulates RhoA activity. We show that Fam65b binds the small GTPase RhoA via a non canonical domain and represses its activity by decreasing its GTP loading. As a consequence, Fam65b negatively regulates chemokine-induced responses such as adhesion, morphological polarisation and migration. Therefore, these results show the existence of a new functional link between FOXO1 and RhoA pathways, through which the FOXO1 target Fam65b tonically dampens chemokine-induced migration by repressing RhoA activity

    Solvothermal processes and the synthesis of nitrides

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    Nitrides constitute an important class of materials due to their physical properties. In this way, all processes related to their synthesis or shaping are of relevant interest. A solvothermal process can be described as a reaction between precursors in a close system in the presence of a solvent and at a temperature higher than the boiling point of the solvent, with pressure being consequently involved. Depending on the pressure and temperature, the solvent is in sub- or supercritical conditions. The system precursors/solvent can be either homogeneous or heterogeneous. Concerning nitrides, solvothermal processes have been mainly developed in three domains: 1. the preparation of novel compositions / 2. the elaboration of nanocrystallites well defined in size and morphology / 3. the crystal-growth of functional nitrides such as GaN. Considering the synthesis of novel nitrides, different solvothermal reactions can be used versus the nitriding agent (N3- or N./GHPR_A_350185_O_XML_IMAGES/GHPR_A_350185_O_ILM0001.gif ) and the nature of the solvent (nitriding solvent or non-reactive solvent). Different examples will be given and the potentialities of solvothermal processes in the preparation of novel nitrides will be discussed
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