A survey of native parasitoids ofHalyomorpha halysin Northern Italy and Switzerland

Introduction: The brown marmorated stink bug, Halyomorpha halys,is an Asian polyphagous species that has become an invasive crop pest in North America and Europe. After its first detection in Switzerland in 2004, it was subsequently found in other European countries such as Italy, where, since 2012, it has rapidly spread in the northern regions, becoming a threat to many crops, especially in pear and peach orchards. Results/Conclusion: Overall, most egg parasitism was due to the generalist parasitoid Anastatus sp. (Eupelmidae) and, at a lower level, to various Scelionidae species (e.g. Trissolcus cultratus). In northern Italy, the amount of parasitized eggs ranged from 3.1% in 2014 to 0.9% in 2015 in Emilia Romagna, and from 0.3% on exposed egg-masses to 21.4% on egg-masses collected in a natural habitat in 2015 in Piedmont. Overall parasitism in Switzerland was 4.4% in 2013

Using functional annotations to study pairwise interactions in urinary tract infection communities

The behaviour of microbial communities depends on environmental factors and on the interactions of the community members. This is also the case for urinary tract infection (UTI) microbial communities. Here, we devise a computational approach that uses indices of complementarity and competition based on metabolic gene annotation to rapidly predict putative interactions between pair of organisms with the aim to explain pairwise growth effects. We apply our method to 66 genomes selected from online databases, which belong to 6 genera representing members of UTI communities. This resulted in a selection of metabolic pathways with high correlation for each pairwise combination between a complementarity index and the experimentally derived growth data. Our results indicated that Enteroccus spp. were most complemented in its metabolism by the other members of the UTI community. This suggests that the growth of Enteroccus spp. can potentially be enhanced by complementary metabolites produced by other community members. We tested a few putative predicted interactions by experimental supplementation of the relevant predicted metabolites. As predicted by our method, folic acid supplementation led to the increase in the population density of UTI Enterococcus isolates. Overall, we believe our method is a rapid initial in silico screening for the prediction of metabolic interactions in microbial communities

Spin-to-orbital angular momentum conversion in focusing, scattering, and imaging systems

We present a general theory of spin-to-orbital angular momentum (AM) conversion of light in focusing, scattering, and imaging optical systems. Our theory employs universal geometric transformations of non-paraxial optical fields in such systems and allows for direct calculation and comparison of the AM conversion efficiency in different physical settings. Observations of the AM conversions using local intensity distributions and far-field polarimetric measurements are discussed

Halyomorpha halys in Italy: first results of field monitoring in fruit orchards

The invasive pest Brown Marmorated Stink Bug (BMSB) Halyomorpha halys (Heteroptera, Pentatomidae) was detected for the first time in Italy in September 2012 in Modena province (Northern Italy) during an insect collection for educational purposes. A survey performed in 2013 allowed to detect its presence in Emilia Romagna, Lombardy and Piedmont regions. In 2014, in the provinces of Modena, Reggio Emilia and Bologna a periodical active field monitoring was performed using tree beating, sweep-net and visual observations in selected orchards and vineyards, recording numbers of BMSB adults and nymphs, and of other Heteroptera. Besides, fruit injury and crop loss were recorded at harvest. Partial results from field data obtained between April and July 2014 are presented, indicating that BMSB is already becoming an important pest of fruit orchards and that special attention should be deserved to monitor its spread all over the region and the whole Italian country

The use of rapamycin to treat vascular tumours and malformations: A single-centre experience

Objectives: To assess the safety and efficacy of rapamycin in treating children with vascular tumours and malformations. Study design: We performed a retrospective review at a large tertiary care paediatric centre to assess the efficacy and safety of using rapamycin to treat vascular tumours and malformations. Response to therapy was defined by patient-reported symptom improvement, radiological reduction in size of lesions, and/or improvement of laboratory parameters. Results: Forty-two patients (7 with vascular tumours and 35 with vascular malformations) have been treated with rapamycin. Despite 33 of 42 patients being diagnosed in the first year of life, the median age of initiating rapamycin was 11 years. Of the 38 children treated for a minimum of 4 months, 29 (76%) exhibited a clinical response. Twenty-one patients had follow-up imaging studies and of these, 16 (76%) had radiographic decrease in lesion size. Median time to demonstration of response was 49 days. All five children with vascular tumours and all three children with vascular malformations under the age of 4 years showed a clinical response. Response rate was lower for children ≥ 4 years of age (0/2, 0% for vascular tumours; 21/28, 75% for vascular malformations). No patient experienced an infection directly related to rapamycin or discontinued rapamycin due to toxicity. Conclusions: Rapamycin is safe and efficacious in most children with select vascular tumours and malformations. Young children appear to respond better, suggesting that early initiation of rapamycin should be considered

Epstein Barr virus in relation to apoptosis markers and patients' outcome in pediatric B-cell Non-Hodgkin lymphoma

In this study, we investigated Epstein Barr virus (EBV) presence, associated to proliferation and apoptosis proteins in pediatric B-cell Non-Hodgkin lymphoma (B-NHL). EBERs, Ki67, active caspase 3, Bax and Bcl2 were analyzed on B-NHL tissue from 40 patients. Forty percent showed EBV expression, significantly higher among patients ≤10. years (P= 0.027), and associated with immunosuppression (P= 0.020), but not associated apotosis markers. However, EBV was associated with a worse event-free survival (P= 0.016), particularly under immunosuppression. Even though EBV did not seem to alter apoptotic pathways, it exhibited survival disadvantage and could be an important cofactor in B-cell lymphomagenesis in younger children.Fil: Chabay, Paola Andrea. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Lara, María Julia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Lorenzetti, Mario Alejandro. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Cambra, P.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Acosta Haab, G.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Aversa, L.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: de Matteo, Elena Noemí. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Preciado, María Victoria. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentin

Site analysis in the Argentinean Andean region for the placement of astrophysical observatories and solar photovoltaic power plants: The case of the “Leoncito 2” site

After a detailed search for possible sites where to place astrophysical facilities in Argentinean Andean region, a location labeled as LEO 2 (31°24′22″ S, 69°29′32″ W, 1630 masl) is proposed. It is placed near the largest Astronomical Observatory of Argentina: Complejo AStronómico El LEOncito (CASLEO). Its advantages are: a good altitude to detect the maximum development of cosmic ray showers, high spectral transmittance to UV and visible ranges, very low aerosol content (mean particle concentration measured at ground with an optical particle counter PM2.5 = 1.52 µg m−3 and PM>2.5 = 6.83 µg m−3, mean Aerosol Optical Depth at 550 nm = 0.027 (measured from space using the SeaWiFS instrument on board of the SeaStar NASA satellite). A local meteorological analysis was done, using data measured in situ, which shows a typical desertic site with the following mean annual (std. dev.) values:mean annual temperature 18.93 (7.66) °C, mean annual relative humidity 28.76 (20.55)%, low/ moderate mean annual average wind speed 11.63 (8.78) km/h, low mean water content (0.73 cm) and rather low mean cloud coverage fraction (cloud coverage fraction): 0.29 (0.02) (for the period 2003–2016 from Aqua/NASA satellite MODIS device) and 0.25 (0.01) (for the period 2000–2016, Terra/NASA satellite MODIS device). Concerning the conditions for the placement of photovoltaic solar power plants, some positive aspects that can be remarked are a large rather flat available surface (336 km2) with very good levels of annual mean horizontal solar irradiation: Global (2334 kWh m−2 per year), Direct (3127 kWh m−2 per year) and Diffuse (394 kWh m−2 per year). Optimum angle to place solar panels at this site is determined and the global tilted solar irradiation is calculated (2689 kWh m−2 per year). In comparison with an African (Ouarzazate, Morocco) and Asian (Dubai) sites, the analysed site present better annual irradiation levels being the Global horizontal irradiation at the Argentinean site 8.1% and 10.3% higher than those calculated for the African and Asian site respectively. Also, a comparison is made of different solar cells (monocrystalline Si, polycrystalline Si and perovskite), through the calculation of the generated photocurrent (mean produced solar photovoltaic current per unit cell surface), considering the atmospheric and solar radiation parameters found for the studied site. We thus conclude that the proposed site in the Andes range is well suited for the placement of Astrophysical facilities, as well as Photovoltaic solar power plants.Fil: Freire, Martín Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Della Ceca, Lara Sofia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Micheletti, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Novara, Ivan Lionel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; ArgentinaFil: Garcia, Beatriz Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Tecnología en Detección y Astropartículas. Comisión Nacional de Energía Atómica. Instituto de Tecnología en Detección y Astropartículas. Universidad Nacional de San Martín. Instituto de Tecnología en Detección y Astropartículas; ArgentinaFil: Mancilla, Alexis Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Tecnología en Detección y Astropartículas. Comisión Nacional de Energía Atómica. Instituto de Tecnología en Detección y Astropartículas. Universidad Nacional de San Martín. Instituto de Tecnología en Detección y Astropartículas; ArgentinaFil: Salum, G. M.. Universidad YachayTech; EcuadorFil: Crinó, E.. Universidad Nacional de San Luis; ArgentinaFil: Piacentini, Ruben Dario Narciso. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Rosario. Instituto de Física de Rosario. Universidad Nacional de Rosario. Instituto de Física de Rosario; Argentin

Endovascular treatment improves cognition after stroke. A secondary analysis of REVASCAT trial

Objective: To investigate the effect of endovascular treatment on cognitive function as a prespecified secondary analysis of the REVASCAT (Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours) trial. Methods: REVASCAT randomized 206 patients with anterior circulation proximal arterial occlusion stroke to Solitaire thrombectomy or best medical treatment alone. Patients with established dementia were excluded from enrollment. Cognitive function was assessed in person with Trail Making Test (TMT) Parts A and B at 3 months and 1 year after randomization by an investigator masked to treatment allocation. Test completion within 5 minutes, time of completion (seconds), and number of errors were recorded. Results: From November 2012 to December 2014, 206 patients were enrolled in REVASCAT. TMT was assessed in 82 of 84 patients undergoing thrombectomy and 86 of 87 control patients alive at 3 months and in 71 of 79 patients undergoing thrombectomy and 72 of 78 control patients alive at 1 year. Rates of timely TMT-A completion were similar in both treatment arms, although patients undergoing thrombectomy required less time for TMT-A completion and had higher rates of error-free TMT-A performance. Thrombectomy was also associated with a higher probability of timely TMT-B completion (adjusted odds ratio 3.17, 95% confidence interval 1.51-6.66 at 3 months; and adjusted ratio 3.66, 95% confidence interval 1.60-8.35 at 1 year) and shorter time for TMT-B completion. Differences in TMT completion times between treatment arms were significant in patients with good functional outcome but not in those who were functionally dependent (modified Rankin Scale score >2). Poorer cognitive outcomes were significantly associated with larger infarct volume, higher modified Rankin Scale scores, and worse quality of life. Conclusions: Thrombectomy improves TMT performance after stroke, especially among patients who reach good functional recovery. Classification of evidence: This study provides Class I evidence that for patients with stroke from acute anterior circulation proximal arterial occlusion, thrombectomy improves performance on the TMT at 3 months