504 research outputs found

    Magnetic noise reduction of in-wheel permanent magnet synchronous motors for light-duty electric vehicles

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    This paper presents study of a multi-slice subdomain model (MS-SDM) for persistent low-frequency sound, in a wheel hub-mounted permanent magnet synchronous motor (WHM-PMSM) with a fractional-slot non-overlapping concentrated winding for a light-duty, fully electric vehicle applications. While this type of winding provides numerous potential benefits, it has also the largest magnetomotive force (MMF) distortion factor, which leads to the electro-vibro-acoustics production, unless additional machine design considerations are carried out. To minimize the magnetic noise level radiated by the PMSM, a skewing technique is targeted with consideration of the natural frequencies under a variable-speed-range analysis. To ensure the impact of the minimization technique used, magnetic force harmonics, along with acoustic sonograms, is computed by MS-SDM and verified by 3D finite element analysis. On the basis of the studied models, we derived and experimentally verified the optimized model with 5 dBA reduction in A-weighted sound power level by due to the choice of skew angle. In addition, we investigated whether or not the skewing slice number can be of importance on the vibro-acoustic objectives in the studied WHM-PMSM.Postprint (published version

    Spectrum of slow and super-slow (picosecond to nanosecond) water dynamics around organic and biological solutes

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    Water dynamics in the solvation shell of solutes plays a very important role in the interaction of biomolecules and in chemical reaction dynamics. However, a selective spectroscopic study of the solvation shell is difficult because of the interference of the solute dynamics. Here we report on the observation of heavily slowed down water dynamics in the solvation shell of different solutes by measuring the low-frequency spectrum of solvation water, free from the contribution of the solute. A slowdown factor of ~50 is observed even for relatively low concentrations of the solute. We go on to show that the effect can be generalized to different solutes including proteins

    Overview of Sensitivity Analysis Methods Capabilities for Traction AC Machines in Electrified Vehicles

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    © 2021 The Author(s). This work is licensed under a Creative Commons Attribution 4.0 License. For more information, see https://creativecommons.org/licenses/by/4.0/.A robust design in electrified powertrains substantially helps to enhance the vehicle's overall efficiency. Robustness analyses come with complexity and computational costs at the vehicle level. The use of sensitivity analysis (SA) methods in the design phase has gained popularity in recent years to improve the performance of road vehicles while optimizing the resources, reducing the costs, and shortening the development time. Designers have started to utilize the SA methods to explore: i) how the component and vehicle level design options affect the main outputs i.e. energy efficiency and energy consumption; ii) observing sub-dependent parameters, which might be influenced by the variation of the targeted controllable (i.e. magnet thickness) and uncontrollable (i.e. magnet temperature) variables, in nonlinear dynamic systems; and iii) evaluating the interactions, of both dependent, and sub-dependent controllable/uncontrollable variables, under transient conditions. Hence the aim of this study is to succinctly review recent utilization of SA methods in the design of AC electric machines (EM)s used in vehicle powertrains, to evaluate and discuss the findings presented in recent research papers while summarizing the current state of knowledge. By systematically reviewing the literature on applied SAs in electrified powertrains, we offer a bibliometric analysis of the trends of application-oriented SA studies in the last and next decades. Finally, a numerical-based case study on a third-generation TOYOTA Prius EM will be given, to verify the SA-related findings of this article, alongside future works recommendations.Peer reviewe

    A comparative study of Quasi-FEA technique on iron losses prediction for permanent magnet synchronous machines

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    The paper presents an advanced quasi-FEA technique on the iron losses prediction using Bertotti’s iron loss separation models, in which a curve fitting is taken into account for coefficients calculation of each model. Moreover, the skin effect and saturation consideration are applied in order to check the accuracy through the relative error distribution in the frequency domain of each model from low up to high frequencies 50 to 700 (Hz). Additionally, this comparative study presents a torquespeed-flux density computation that is discussed and presented. The iron loss characteristics of a radial flux permanent magnet synchronous machine (PMSM) with closed-slots and outer rotor topology are also discussed. The quasi-finite-element (FE) analysis was performed using a 2-D and 3-D FEA, where the employed quasi-2-D FEA is proposed and compared with 3-D FEA, and along with experimental verifications. Finally, all the iron-loss models under realistic and non-ideal magnetization conditions are verified experimentally on a surface-mounted PMSG for wind generation application.Peer ReviewedPostprint (published version

    The molecular relationship between antigenic domains and epitopes on hCG

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    Antigenic domains are defined to contain a limited number of neighboring epitopes recognized by antibodies (Abs) but their molecular relationship remains rather elusive. We thoroughly analyzed the antigenic surface of the important pregnancy and tumor marker human chorionic gonadotropin (hCG), a cystine knot (ck) growth factor, and set antigenic domains and epitopes in molecular relationships to each other. Antigenic domains on hCG, its free hCGα and hCGβ subunits are dependent on appropriate inherent molecular features such as molecular accessibility and protrusion indices that determine bulging structures accessible to Abs. The banana-shaped intact hCG comprises ∼7500 Å2 of antigenic surface with minimally five antigenic domains that encompass a continuum of overlapping non-linear composite epitopes, not taking into account the C-terminal peptide extension of hCGβ (hCGβCTP). Epitopes within an antigenic domain are defined by specific Abs, that bury nearly 1000 Å2 of surface accessible area on the antigen and recognize a few up to 15 amino acid (aa) residues, whereby between 2 and 5 of these provide the essential binding energy. Variability in Ab binding modes to the contact aa residues are responsible for the variation in affinity and intra- and inter-species specificity, e.g. cross-reactions with luteinizing hormone (LH). Each genetically distinct fragment antigen binding (Fab) defines its own epitope. Consequently, recognition of the same epitope by different Abs is only possible in cases of genetically identical sequences of its binding sites. Due to combinatorial V(D)J gene segment variability of heavy and light chains, Abs defining numerous epitopes within an antigenic domain can be generated by different individuals and species. Far more than hundred Abs against the immuno-dominant antigenic domains of either subunit at both ends of the hCG-molecule, the tips of peptide loops one and three (Ł1 + 3) protruding from the central ck, encompassing hCGβŁ1 + 3 (aa 20–25 + 64 + 68–81) and hCGαŁ1 (aa 13–22; Pro16, Phe17, Phe18) plus hCGαŁ3 (Met71, Phe74), respectively, have been identified in the two “ISOBM Tissue Differentiation-7 Workshops on hCG and Related Molecules” and in other studies. These Abs recognize distinct but overlapping epitopes with slightly different specificity profiles and affinities. Heterodimeric-specific epitopes involve neighboring αŁ1 plus βŁ2 (hCGβ44/45 and 47/48). Diagnostically important Abs recognize the middle of the molecule, the ck (aa Arg10, Arg60 and possibly Gln89) and the linear hCGβCTP “tail” (aa 135–145; Asp139, Pro144, Gln145), respectively. Identification of antigenic domains and of specific epitopes is essential for harmonization of Abs in methods that are used for reliable and robust hCG measurements for the management of pregnancy, pregnancy-related disease and tumors

    Observation of coherent delocalized phonon-like modes in DNA under physiological conditions

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    Underdamped terahertz-frequency delocalized phonon-like modes have long been suggested to play a role in the biological function of DNA. Such phonon modes involve the collective motion of many atoms and are prerequisite to understanding the molecular nature of macroscopic conformational changes and related biochemical phenomena. Initial predictions were based on simple theoretical models of DNA. However, such models do not take into account strong interactions with the surrounding water, which is likely to cause phonon modes to be heavily damped and localized. Here we apply state-of-the-art femtosecond optical Kerr effect spectroscopy, which is currently the only technique capable of taking low-frequency (GHz to THz) vibrational spectra in solution. We are able to demonstrate that phonon modes involving the hydrogen bond network between the strands exist in DNA at physiologically relevant conditions. In addition, the dynamics of the solvating water molecules is slowed down by about a factor of 20 compared with the bulk

    The diversity of microbial aldo/keto reductases from Escherichia coli K12

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    The genome of Escherichia coli K12 contains 9 open reading frames encoding aldo/keto reductases (AKRs) that are differentially regulated and sequence diverse. A significant amount of data is available for the E. coli AKRs through the availability of gene knockouts and gene expression studies, which adds to the biochemical and kinetic data. This together with the availability of crystal structures for nearly half of the E. coli AKRs and homologues of several others provides an opportunity to look at the diversity of these representative bacterial AKRs. Based around the common AKR fold of (β/α)8 barrel with two additional α-helices, the E. coli AKRs have a loop structure that is more diverse than their mammalian counterparts, creating a variety of active site architectures. Nearly half of the AKRs are expected to be monomeric, but there are examples of dimeric, trimeric and octameric enzymes, as well as diversity in specificity for NAD as well as NADP as a cofactor. However in functional assignments and characterisation of enzyme activities there is a paucity of data when compared to the mammalian AKR enzymes
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