1,085 research outputs found
Control of bone remodelling by applied dynamic loads
The data showing the relationship between bone mass and peak strain magnitude prepared and submitted for publication. The data from experiments relating remodelling activity with static or dynamic loads were prepared and submitted for publication. Development of programs to relate the location of remodelling activity with he natural and artificial dynamic strain distributions continued. Experiments on the effect of different strain rates on the remodelling response continued
Static versus dynamic loads as an influence on bone remodelling
Bone remodelling activity in the avian ulna was assessed under conditions of disuse alone, disuse with a superimposed continuous compressive load, and disuse interrupted by a short daily period of intermittent loading. The ulna preparation is made by two submetaphyseal osteotomies, the cut ends of the bone being covered with stainless steel caps which, together with the bone they enclosed, are pierced by pins emerging transcutaneously on the dorsal and ventral surfaces of the wing. The 110 mm long undisturbed section of the bone shaft can be protected from functional loading, loaded continuously in compression by joining the pins with springs, or loaded intermittently in compression by engaging the pins in an Instron machine. Similar loads (525 n) were used in both static and dynamic cases engendering similar peak strains at the bone's midshaft (-2000 x 10-6). The intermitent load was applied at a frequency of 1 Hz during a single 100 second period per day as a ramped square wave, with a rate of change of strain during the ramp of 0.01 per second
Shor's quantum factoring algorithm on a photonic chip
Shor's quantum factoring algorithm finds the prime factors of a large number
exponentially faster than any other known method a task that lies at the heart
of modern information security, particularly on the internet. This algorithm
requires a quantum computer a device which harnesses the `massive parallelism'
afforded by quantum superposition and entanglement of quantum bits (or qubits).
We report the demonstration of a compiled version of Shor's algorithm on an
integrated waveguide silica-on-silicon chip that guides four single-photon
qubits through the computation to factor 15.Comment: 2 pages, 1 figur
Manipulating biphotonic qutrits
Quantum information carriers with higher dimension than the canonical qubit
offer significant advantages. However, manipulating such systems is extremely
difficult. We show how measurement induced non-linearities can be employed to
dramatically extend the range of possible transforms on biphotonic qutrits; the
three level quantum systems formed by the polarisation of two photons in the
same spatio-temporal mode. We fully characterise the biphoton-photon
entanglement that underpins our technique, thereby realising the first instance
of qubit-qutrit entanglement. We discuss an extension of our technique to
generate qutrit-qutrit entanglement and to manipulate any bosonic encoding of
quantum information.Comment: 4 pages, 4 figure
Sclerostin's role in bone's adaptive response to mechanical loading
Mechanical loading is the primary functional determinant of bone mass and architecture, and osteocytes play a key role in translating mechanical signals into (re)modelling responses. Although the precise mechanisms remain unclear, Wnt signalling pathway components, and the anti-osteogenic canonical Wnt inhibitor Sost/sclerostin in particular, play an important role in regulating bone's adaptive response to loading. Increases in loading-engendered strains down-regulate osteocyte sclerostin expression, whereas reduced strains, as in disuse, are associated with increased sclerostin production and bone loss. However, while sclerostin up-regulation appears to be necessary for the loss of bone with disuse, the role of sclerostin in the osteogenic response to loading is more complex. While mice unable to down-regulate sclerostin do not gain bone with loading, Sost knockout mice have an enhanced osteogenic response to loading. The molecular mechanisms by which osteocytes sense and transduce loading-related stimuli into changes in sclerostin expression remain unclear but include several, potentially interlinked, signalling cascades involving periostin/integrin, prostaglandin, estrogen receptor, calcium/NO and Igf signalling. Deciphering the mechanisms by which changes in the mechanical environment regulate sclerostin production may lead to the development of therapeutic strategies that can reverse the skeletal structural deterioration characteristic of disuse and age-related osteoporosis and enhance bones' functional adaptation to loading. By enhancing the osteogenic potential of the context in which individual therapies such as sclerostin antibodies act it may become possible to both prevent and reverse the age-related skeletal structural deterioration characteristic of osteoporosis
Quantum Algorithm for Molecular Properties and Geometry Optimization
It is known that quantum computers, if available, would allow an exponential
decrease in the computational cost of quantum simulations. We extend this
result to show that the computation of molecular properties (energy
derivatives) could also be sped up using quantum computers. We provide a
quantum algorithm for the numerical evaluation of molecular properties, whose
time cost is a constant multiple of the time needed to compute the molecular
energy, regardless of the size of the system. Molecular properties computed
with the proposed approach could also be used for the optimization of molecular
geometries or other properties. For that purpose, we discuss the benefits of
quantum techniques for Newton's method and Householder methods. Finally, global
minima for the proposed optimizations can be found using the quantum basin
hopper algorithm, which offers an additional quadratic reduction in cost over
classical multi-start techniques.Comment: 6 page
Calculating Unknown Eigenvalues with a Quantum Algorithm
Quantum algorithms are able to solve particular problems exponentially faster
than conventional algorithms, when implemented on a quantum computer. However,
all demonstrations to date have required already knowing the answer to
construct the algorithm. We have implemented the complete quantum phase
estimation algorithm for a single qubit unitary in which the answer is
calculated by the algorithm. We use a new approach to implementing the
controlled-unitary operations that lie at the heart of the majority of quantum
algorithms that is more efficient and does not require the eigenvalues of the
unitary to be known. These results point the way to efficient quantum
simulations and quantum metrology applications in the near term, and to
factoring large numbers in the longer term. This approach is architecture
independent and thus can be used in other physical implementations
Adding control to arbitrary unknown quantum operations
While quantum computers promise significant advantages, the complexity of
quantum algorithms remains a major technological obstacle. We have developed
and demonstrated an architecture-independent technique that simplifies adding
control qubits to arbitrary quantum operations-a requirement in many quantum
algorithms, simulations and metrology. The technique is independent of how the
operation is done, does not require knowledge of what the operation is, and
largely separates the problems of how to implement a quantum operation in the
laboratory and how to add a control. We demonstrate an entanglement-based
version in a photonic system, realizing a range of different two-qubit gates
with high fidelity.Comment: 9 pages, 8 figure
Experimental feedback control of quantum systems using weak measurements
A goal of the emerging field of quantum control is to develop methods for
quantum technologies to function robustly in the presence of noise. Central
issues are the fundamental limitations on the available information about
quantum systems and the disturbance they suffer in the process of measurement.
In the context of a simple quantum control scenario--the stabilization of
non-orthogonal states of a qubit against dephasing--we experimentally explore
the use of weak measurements in feedback control. We find that, despite the
intrinsic difficultly of implementing them, weak measurements allow us to
control the qubit better in practice than is even theoretically possible
without them. Our work shows that these more general quantum measurements can
play an important role for feedback control of quantum systems.Comment: 4 pages, 3 figures. v2 Added extra citation, journal reference and
DOI. Minor typographic correction
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