Global trends in the research of biodegradable biomedical magnesium-based materials: a bibliometric analysis

Background: In recent years, there has been a notable surge in the interest surrounding biodegradable materials, particularly in the context of biomedical applications. This has led to a significant rise in the number of research studies focusing on the utilization of biodegradable magnesium-based materials in the field of biomedicine. However, a dearth of comprehensive assessment exists regarding the body of research concerning biodegradable biomedical magnesium-based materials. In this study, a bibliometric approach was used to illustrate the current state of research and global trends pertaining to biodegradable magnesium-based materials for biomedical applications.Methods: We conducted a search of the Web of Science core collection database for the past decade (2013–2022). VOSviewer software and the bibliometric online analysis platform were employed for bibliometric analysis and visualization.Results: Correspondingly, 1267 documents were retrieved. We discovered that the number of papers in the field of degradable biomedical magnesium-based materials research has increased annually. In addition, China and the Chinese Academy of Sciences have published the largest number of papers in the field of biodegradable biomedical magnesium-based materials. Papers related to biodegradable magnesium-based materials for biomedical use were mainly published in acta biomaterialia, materials science and engineering c-materials for biological applications and materials journals. Keyword co-occurrence analysis showed that “corrosion"and “mechanical-properties” appear more frequently. The top 10 common keywords include corrosion, mechanical-properties, microstructure, biocompatibility, behavior, magnesium, magnesium alloys, degradation magnesium alloy, in vitro.Conclusion: Research on biodegradable magnesium-based materials for biomedical use continues to increase steadily. China maintains a leading position in the world, and the Chinese Academy of Sciences represents a notable contribution to the research of biodegradable magnesium-based materials for biomedical use. Subsequently, “corrosion” and “mechanical-properties” were identified as the current research hotspots in the area of biodegradable biomedical magnesium-based materials

An Update on Eosinophilic Esophagitis: Etiological Factors, Coexisting Diseases, and Complications

BACKGROUND: Eosinophilic esophagitis (EoE) is an immune-mediated clinicopathological condition characterized by esophageal infiltration with eosinophils resulting in chronic inflammation and stricture. SUMMARY: The recent increase in the incidence of EoE and the characteristic presentation of symptoms with difficulty swallowing and food bolus impaction has raised key concerns of clinicians as well as researchers. EoE often presents with dysphagia, food impaction, nausea, regurgitation or vomiting, and decreased appetite. It is more common in males, affecting both adults and children. The causative manner of this condition is complex and multifactorial. Throughout recent years, researchers have made a significant contribution to understanding the pathogenesis of EoE, genetic background, natural history, work on allergy, and standardization in the evaluation of disease activity. There is relatively high prevalence of EoE among the population, emphasizing the importance of this disease. Key messages: Esophageal involvement with eosinophils may be manifested as isolated or with coexisting conditions and should be taken into consideration in the differential diagnosis. This study aimed to provide gastroenterologists with novel insights into the evaluation of esophageal involvement with eosinophils and to pay special attention to the etiological factors, coexisting clinical diseases, and complications

Identification of genes regulated by Wnt/β-catenin pathway and involved in apoptosis via microarray analysis

BACKGROUND: Wnt/β-catenin pathway has critical roles in development and oncogenesis. Although significant progress has been made in understanding the downstream signaling cascade of this pathway, little is known regarding Wnt/β-catenin pathway modification of the cellular apoptosis. METHODS: To identify potential genes regulated by Wnt/β-catenin pathway and involved in apoptosis, we used a stably integrated, inducible RNA interference (RNAi) vector to specific inhibit the expression and the transcriptional activity of β-catenin in HeLa cells. Meanwhile, we designed an oligonucleotide microarray covering 1384 apoptosis-related genes. Using oligonucleotide microarrays, a series of differential expression of genes was identified and further confirmed by RT-PCR. RESULTS: Stably integrated inducible RNAi vector could effectively suppress β-catenin expression and the transcriptional activity of β-catenin/TCF. Meanwhile, depletion of β-catenin in this manner made the cells more sensitive to apoptosis. 130 genes involved in some important cell-apoptotic pathways, such as PTEN-PI3K-AKT pathway, NF-κB pathway and p53 pathway, showed significant alteration in their expression level after the knockdown of β-catenin. CONCLUSION: Coupling RNAi knockdown with microarray and RT-PCR analyses proves to be a versatile strategy for identifying genes regulated by Wnt/β-catenin pathway and for a better understanding the role of this pathway in apoptosis. Some of the identified β-catenin/TCF directed or indirected target genes may represent excellent targets to limit tumor growth

Existence and Continuous Dependence for Fractional Partial Hyperbolic Differential Equations

This paper is concerned with a class of fractional hyperbolic partial differential equations with the Caputo derivative. Existence and continuous dependence results of solutions are obtained under the hypothesis of the Lipschitz condition without any restriction on the Lipschitz constant. Examples are discussed to illustrate the results