Exposure to maternal cafeteria diets during the suckling period has greater effects on fat deposition and Sterol regulatory element binding protein-1c (SREBP-1c) gene expression in rodent offspring compared to exposure before birth

Background: While the adverse metabolic effects of exposure to obesogenic diets during both the prenatal and early postnatal period are well established, the relative impact of exposure during these separate developmental windows remains unclear. Objective: This study aimed to assess the relative contribution of exposure to a maternal cafeteria diet during pregnancy and lactation on body weight, fat mass and expression of lipogenic and adipokine genes in the offspring. Methods: Wistar rats were fed either a control chow (Control, n=14) or obesogenic cafeteria diet (CAF, n=12) during pregnancy and lactation. Pups were cross-fostered to another dam in either the same or different dietary group within 24 h of birth. Body weight, body fat mass and expression of lipogenic and adipokine genes in subcutaneous and visceral adipose tissues were determined in offspring at weaning and 3 weeks post-weaning. Results: Offspring suckled by CAF dams had a lower body weight (

Transport and drift-driven plasma flow components in the Alcator C-Mod boundary plasma

Boundary layer flows in the Alcator C-Mod tokamak are systematically examined as magnetic topology (upper versus lower-null) and plasma density are changed. Utilizing a unique set of scanning Langmuir–Mach probes, including one on the high-field side (HFS) midplane, the poloidal variation of plasma flow components in the parallel, diamagnetic and radial directions are resolved in detail. It is found that the plasma flow pattern can be decomposed into two principal parts: (1) a drift-driven component, which lies within a magnetic flux surface and is divergence-free and (2) a transport-driven component, which gives rise to near-sonic parallel flows on the HFS scrape-off layer (SOL). Toroidal rotation, Pfirsch–Schlüter and transport-driven contributions are unambiguously identified. Transport-driven parallel flows are found to dominate the HFS particle fluxes; the total poloidal-directed flow accounts for ~1/3 to all of the ion flux arriving on the inner divertor. As a result, heat convection is found to be an important player in this region, consistent with the observation of divertor asymmetries that depend on the direction of B × ∇B relative to the active x-point. In contrast, the poloidal projection of parallel flow in the low-field SOL largely cancels with E[subscript r] × B flow; toroidal rotation is the dominant plasma motion there. The magnitude of the transport-driven poloidal flow is found to be quantitatively consistent with fluctuation-induced radial particle fluxes on the low-field side (LFS), identifying this as the primary drive mechanism. Fluctuation-induced fluxes on the HFS are found to be essentially zero, excluding turbulent inward transport as the mechanism that closes the circulation loop in this region.United States. Dept. of Energy (Cooperative Agreement DE-FC02-99ER54512

Precision Pion-Proton Elastic Differential Cross Sections at Energies Spanning the Delta Resonance

A precision measurement of absolute pi+p and pi-p elastic differential cross sections at incident pion laboratory kinetic energies from T_pi= 141.15 to 267.3 MeV is described. Data were obtained detecting the scattered pion and recoil proton in coincidence at 12 laboratory pion angles from 55 to 155 degrees for pi+p, and six angles from 60 to 155 degrees for pi-p. Single arm measurements were also obtained for pi+p energies up to 218.1 MeV, with the scattered pi+ detected at six angles from 20 to 70 degrees. A flat-walled, super-cooled liquid hydrogen target as well as solid CH2 targets were used. The data are characterized by small uncertainties, ~1-2% statistical and ~1-1.5% normalization. The reliability of the cross section results was ensured by carrying out the measurements under a variety of experimental conditions to identify and quantify the sources of instrumental uncertainty. Our lowest and highest energy data are consistent with overlapping results from TRIUMF and LAMPF. In general, the Virginia Polytechnic Institute SM95 partial wave analysis solution describes our data well, but the older Karlsruhe-Helsinki PWA solution KH80 does not.Comment: 39 pages, 22 figures (some with quality reduced to satisfy ArXiv requirements. Contact M.M. Pavan for originals). Submitted to Physical Review

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

ISX-B impurity study program

A review of some of the problems associated with tokamak impurities is given. The ISX research program is described. (MOW

Determination of the global recombination rate coefficient for the ISX-B Tokamak

The global recombination rate coefficient for hydrogen has been measured for the ISX-B tokamak vacuum vessel for various surface conditions. The measurements were performed by observing the rate of decrease of gas pressure in the vessel during a glow discharge. The parameters of the glow discharge and the complete experimental method are described. Previously published analytic and numerical models are used for data analysis. The effects of surface contamination on the results are described. For ''unclean'' wall conditions sigmak/sub r/ = 1.8 x 10/sup -28/ cm/sup 4//atom.s at 296 K and increases to sigmak/sub r/ = 4.4 x 10/sup -28/ cm/sup 4//atoms.s for ''clean'' conditions and remains constant until subsequent exposure to air

Initial measurement of impurity production and hydrogen energy distribution from neutral beam injectors

Impurity production and hydrogen energy distributions for neutral beam injectors (NBI) developed by the plasma Technology Section of Oak Ridge National Laboratory's (ORNL's) Fusion Energy Division have been measured by exposing silicon samples to beam pulses and analyzing them by nuclear microanalysis and secondary ion mass spectrometry (SIMS) techniques. The NBI's have been developed for use on the princeton Large Torus (PLT), the Poloidal Divertor Experiment (PDX), and the Impurity Study Experiment (ISX). Extraction voltages O up to 50 kV are used, and maximum power injected for a 0.5-s pulse is approx. 1.2 MW with a design goal of 1.5 MW. The Medium Energy Test Facility (MRTF) was used for exposure of the single-crystal (100) silicon samples

Tokamak first-wall coating program development

The development of a research program to study coatings for control of impurities originating from the first wall of a Tokamak reactor is extensively discussed. The first wall environment and sputtering, temperature, surface chemical, and bulk radiation damage effects are reviewed. Candidate materials and application techniques are discussed. The philosophy and flow chart of a recommended coating development plan are presented and discussed. Projected impacts of the proposed plan include benefits to other aspects of confinement experiments. A list of 45 references is appended. (RME