A plasma protein-based risk score to predict hip fractures

As there are effective treatments to reduce hip fractures, identification of patients at high risk of hip fracture is important to inform efficient intervention strategies. To obtain a new tool for hip fracture prediction, we developed a protein-based risk score in the Cardiovascular Health Study using an aptamer-based proteomic platform. The proteomic risk score predicted incident hip fractures and improved hip fracture discrimination in two Trøndelag Health Study validation cohorts using the same aptamer-based platform. When transferred to an antibody-based proteomic platform in a UK Biobank validation cohort, the proteomic risk score was strongly associated with hip fractures (hazard ratio per s.d. increase, 1.64; 95% confidence interval 1.53–1.77). The proteomic risk score, but not available polygenic risk scores for fractures or bone mineral density, improved the C-index beyond the fracture risk assessment tool (FRAX), which integrates information from clinical risk factors (C-index, FRAX 0.735 versus FRAX + proteomic risk score 0.776). The developed proteomic risk score constitutes a new tool for stratifying patients according to hip fracture risk; however, its improvement in hip fracture discrimination is modest and its clinical utility beyond FRAX with information on femoral neck bone mineral density remains to be determined

Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.

Lung-function impairment underlies chronic obstructive pulmonary disease (COPD) and predicts mortality. In the largest multi-ancestry genome-wide association meta-analysis of lung function to date, comprising 580,869 participants, we identified 1,020 independent association signals implicating 559 genes supported by ≥2 criteria from a systematic variant-to-gene mapping framework. These genes were enriched in 29 pathways. Individual variants showed heterogeneity across ancestries, age and smoking groups, and collectively as a genetic risk score showed strong association with COPD across ancestry groups. We undertook phenome-wide association studies for selected associated variants as well as trait and pathway-specific genetic risk scores to infer possible consequences of intervening in pathways underlying lung function. We highlight new putative causal variants, genes, proteins and pathways, including those targeted by existing drugs. These findings bring us closer to understanding the mechanisms underlying lung function and COPD, and should inform functional genomics experiments and potentially future COPD therapies

Industrie- und Entwicklungslaender in der Auseinandersetzung um eine neue Weltwirtschaftsordnung

Originally published in: Die Internationale Politik, 1975/76. Jahrbuecher des Forschungsinstituts der Deutschen Gesellschaft fuer Auswaertige Politik. Muenchen, Wien. 1981SIGLEDEGerman

Multilateral trade liberalization among developing countries

Originally published in: Journal of World Trade Law. Twickenham. 14. 1980,6SIGLEDEGerman

Ten years of the EEC's generalized system of preferences for Development Countries: Success or failure

SIGLEBibliothek Weltwirtschaft Kiel C 117,913 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman

ASEAN manufactured exports in the EEC markets An empirical assessment of common and national tariff and non-tariff barriers confronting them

SIGLEDEGerman

The importance of ''natural'' barriers to trade among developing countries Some evidence from the transport cost content in Brazilian imports

SIGLEDEGerman

Problems and effects of a developing countries' tariff concession round on South-South trade

SIGLEDEGerman

Hat der europaeische Integrationsprozess die Integration der nationalen Maerkte gefoerdert

SIGLEBibliothek Weltwirtschaft Kiel C 144330 / FIZ - Fachinformationszzentrum Karlsruhe / TIB - Technische InformationsbibliothekDEGerman