7,615 research outputs found
Frustrated Rotations in Nematic Monolayers
Tabe and Yokoyama found recently that the optical axis in a chiral monolayer
of a ferronematic rotates when water evaporates from the bath: the chiral
molecules act as propellers. When the axis is blocked at the lateral walls of
the trough, the accumulated rotation inside creates huge splays and bends. We
discuss the relaxation of these tensions, assuming that a single dust particle
nucleates disclination pairs. For the simplest geometry, we then predict a long
delay time followed by a non-periodic sequence of ``bursts''. These ideas are
checked by numerical simulations.Comment: 5 pages, 4 figures, submitted to Eur. Phys. J.
The detection of extragalactic N: Consequences for nitrogen nucleosynthesis and chemical evolution
Detections of extragalactic N are reported from observations of the
rare hydrogen cyanide isotope HCN toward the Large Magellanic Cloud
(LMC) and the core of the (post-) starburst galaxy NGC 4945. Accounting for
optical depth effects, the LMC data from the massive star-forming region N113
infer a N ratio of 111 17, about twice the C
value. For the LMC star-forming region N159HW and for the central region of NGC
4945, N ratios are also 100. The N ratios
are smaller than all interstellar nitrogen isotope ratios measured in the disk
and center of the Milky Way, strongly supporting the idea that N is
predominantly of `primary' nature, with massive stars being its dominant
source. Although this appears to be in contradiction with standard stellar
evolution and nucleosynthesis calculations, it supports recent findings of
abundant N production due to rotationally induced mixing of protons into
the helium-burning shells of massive stars.Comment: 15 pages including one postscript figure, accepted for publication by
ApJ Letter, further comments: please contact Yi-nan Chi
Coalescence in the 1D Cahn-Hilliard model
We present an approximate analytical solution of the Cahn-Hilliard equation
describing the coalescence during a first order phase transition. We have
identified all the intermediate profiles, stationary solutions of the noiseless
Cahn-Hilliard equation. Using properties of the soliton lattices, periodic
solutions of the Ginzburg-Landau equation, we have construct a family of ansatz
describing continuously the processus of destabilization and period doubling
predicted in Langer's self similar scenario
Structural Stability and Renormalization Group for Propagating Fronts
A solution to a given equation is structurally stable if it suffers only an
infinitesimal change when the equation (not the solution) is perturbed
infinitesimally. We have found that structural stability can be used as a
velocity selection principle for propagating fronts. We give examples, using
numerical and renormalization group methods.Comment: 14 pages, uiucmac.tex, no figure
Area-Constrained Planar Elastica
We determine the equilibria of a rigid loop in the plane, subject to the
constraints of fixed length and fixed enclosed area. Rigidity is characterized
by an energy functional quadratic in the curvature of the loop. We find that
the area constraint gives rise to equilibria with remarkable geometrical
properties: not only can the Euler-Lagrange equation be integrated to provide a
quadrature for the curvature but, in addition, the embedding itself can be
expressed as a local function of the curvature. The configuration space is
shown to be essentially one-dimensional, with surprisingly rich structure.
Distinct branches of integer-indexed equilibria exhibit self-intersections and
bifurcations -- a gallery of plots is provided to highlight these findings.
Perturbations connecting equilibria are shown to satisfy a first order ODE
which is readily solved. We also obtain analytical expressions for the energy
as a function of the area in some limiting regimes.Comment: 23 pages, several figures. Version 2: New title. Changes in the
introduction, addition of a new section with conclusions. Figure 14 corrected
and one reference added. Version to appear in PR
Fabrication of elastomeric stamps with polymer-reinforced sidewalls via chemically selective vapor deposition polymerization of poly(p-xylylene)
We report on the preparation of polydimethylsiloxane stamps with selectively grown polymer sidewalls by chemical vapor deposition polymerization of poly(ppoly(p-xylylene). Using a thin iron layer as an inhibitor, the deposition occurs only on the sidewalls of the features in relief, resulting in a polymer-reinforced stamp. The wetting properties of stamps can be restored after removing the thin iron layer with an acidic solution, which has been verified by pattern transfer to an underlying substrate using molding and microcontact printing. © 2003 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69846/2/APPLAB-83-20-4250-1.pd
Unforgeable Noise-Tolerant Quantum Tokens
The realization of devices which harness the laws of quantum mechanics
represents an exciting challenge at the interface of modern technology and
fundamental science. An exemplary paragon of the power of such quantum
primitives is the concept of "quantum money". A dishonest holder of a quantum
bank-note will invariably fail in any forging attempts; indeed, under
assumptions of ideal measurements and decoherence-free memories such security
is guaranteed by the no-cloning theorem. In any practical situation, however,
noise, decoherence and operational imperfections abound. Thus, the development
of secure "quantum money"-type primitives capable of tolerating realistic
infidelities is of both practical and fundamental importance. Here, we propose
a novel class of such protocols and demonstrate their tolerance to noise;
moreover, we prove their rigorous security by determining tight fidelity
thresholds. Our proposed protocols require only the ability to prepare, store
and measure single qubit quantum memories, making their experimental
realization accessible with current technologies.Comment: 18 pages, 5 figure
Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity
PI3K-related kinases (PIKKs) are large Serine/Threonine (Ser/Thr)-protein kinases central to the regulation of many fundamental cellular processes. PIKK family member SMG1 orchestrates progression of an RNA quality control pathway, termed nonsense-mediated mRNA decay (NMD), by phosphorylating the NMD factor UPF1. Phosphorylation of UPF1 occurs in its unstructured N- and C-terminal regions at Serine/Threonine-Glutamine (SQ) motifs. How SMG1 and other PIKKs specifically recognize SQ motifs has remained unclear. Here, we present a cryo-electron microscopy (cryo-EM) reconstruction of a human SMG1-8-9 kinase complex bound to a UPF1 phosphorylation site at an overall resolution of 2.9 angstrom. This structure provides the first snapshot of a human PIKK with a substrate-bound active site. Together with biochemical assays, it rationalizes how SMG1 and perhaps other PIKKs specifically phosphorylate Ser/Thr-containing motifs with a glutamine residue at position +1 and a hydrophobic residue at position -1, thus elucidating the molecular basis for phosphorylation site recognition
Cryo-EM reconstructions of inhibitor-bound SMG1 kinase reveal an autoinhibitory state dependent on SMG8
The PI3K-related kinase (PIKK) SMG1 monitors the progression of metazoan nonsense-mediated mRNA decay (NMD) by phosphorylating the RNA helicase UPF1. Previous work has shown that the activity of SMG1 is impaired by small molecule inhibitors, is reduced by the SMG1 interactors SMG8 and SMG9, and is downregulated by the so-called SMG1 insertion domain. However, the molecular basis for this complex regulatory network has remained elusive. Here, we present cryo-electron microscopy reconstructions of human SMG1-9 and SMG1-8-9 complexes bound to either a SMG1 inhibitor or a non-hydrolyzable ATP analog at overall resolutions ranging from 2.8 to 3.6 angstrom. These structures reveal the basis with which a small molecule inhibitor preferentially targets SMG1 over other PIKKs. By comparison with our previously reported substrate-bound structure (Langer et al.,2020), we show that the SMG1 insertion domain can exert an autoinhibitory function by directly blocking the substrate-binding path as well as overall access to the SMG1 kinase active site. Together with biochemical analysis, our data indicate that SMG1 autoinhibition is stabilized by the presence of SMG8. Our results explain the specific inhibition of SMG1 by an ATP-competitive small molecule, provide insights into regulation of its kinase activity within the NMD pathway, and expand the understanding of PIKK regulatory mechanisms in general.Acknowledgements: Daniel Bollschweiler and Tillman SchÀfer at the MPIB cryo-EM facility for help with EM data collection and Barbara Steigenberger and Elisabeth Weyher at MPIB biochemistry core facility for carrying out mass spectrometry
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