The occurrence of classical Cepheids in binary systems

Classical Cepheids, like binary stars, are laboratories for stellar evolution and Cepheids in binary systems are especially powerful ones. About one-third of Galactic Cepheids are known to have companions and Cepheids in eclipsing binary systems have recently been discovered in the Large Magellanic Cloud. However, there are no known Galactic binary Cepheids with orbital periods less than one year. We compute population synthesis models of binary Cepheids to compare to the observed period and eccentricity distributions of Galactic Cepheids as well as to the number of observed eclipsing binary Cepheids in the LMC. We find that our population synthesis models are consistent with observed binary properties of Cepheids. Furthermore, we show that binary interaction on the red giant branch prevents some red giant stars from becoming classical Cepheids. Such interactions suggest that the binary fraction of Cepheids should be significantly less than that of their main-sequence progenitors, and that almost all binary Cepheids have orbital periods longer than one year. If the Galactic Cepheid spectroscopic binary fraction is about 35%, then the spectroscopic binary fraction of their intermediate mass main sequence progenitors is about 40-45%.Comment: 7 pages, 3 figures, resubmitted to A&

Towards an Understanding of the Mid-Infrared Surface Brightness of Normal Galaxies

We report a mid-infrared color and surface brightness analysis of IC 10, NGC 1313, and NGC 6946, three of the nearby galaxies studied under the Infrared Space Observatory Key Project on Normal Galaxies. Images with < 9 arcsecond (170 pc) resolution of these nearly face-on, late-type galaxies were obtained using the LW2 (6.75 mu) and LW3 (15 mu) ISOCAM filters. Though their global I_nu(6.75 mu)/I_nu(15 mu) flux ratios are similar and typical of normal galaxies, they show distinct trends of this color ratio with mid-infrared surface brightness. We find that I_nu(6.75 mu)/I_nu(15 mu) ~< 1 only occurs for regions of intense heating activity where the continuum rises at 15 micron and where PAH destruction can play an important role. The shape of the color-surface brightness trend also appears to depend, to the second-order, on the hardness of the ionizing radiation. We discuss these findings in the context of a two-component model for the phases of the interstellar medium and suggest that star formation intensity is largely responsible for the mid-infrared surface brightness and colors within normal galaxies, whereas differences in dust column density are the primary drivers of variations in the mid-infrared surface brightness between the disks of normal galaxies.Comment: 19 pages, 6 figures, uses AAS LaTeX; to appear in the November Astronomical Journa

Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications

This work was supported by a restricted research grant of Bayer AG

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

The occurrence of classical Cepheids in binary systems

Classical Cepheids, like binary stars, are laboratories for stellar evolution and Cepheids in binary systems are especially powerful ones. About one-third of Galactic Cepheids are known to have companions and Cepheids in eclipsing binary systems have recently been discovered in the Large Magellanic Cloud (LMC). However, there are no known Galactic binary Cepheids with orbital periods less than one year. We compute population synthesis models of binary Cepheids to compare to the observed period and eccentricity distributions of Galactic Cepheids as well as to the number of observed eclipsing binary Cepheids in the LMC. We find that our population synthesis models are consistent with observed binary properties of Cepheids. Furthermore, we show that binary interaction on the red giant branch prevents some red giant stars from becoming classical Cepheids. Such interactions suggest that the binary fraction of Cepheids should be significantly less than that of their main-sequence progenitors, and that almost all binary Cepheids have orbital periods longer than one year. If the Galactic Cepheid spectroscopic binary fraction is about 35%, then the spectroscopic binary fraction of their intermediate mass main sequence progenitors is about 40−45%

Poetry as praxis: An exploration of poetry discourse as qualitative inquiry

To capture the essence of an experience, poetry as research may manifest itself in two ways: (i) creating a research poem from existing data, often transcripts, or (ii) using participants\u27 poetry as a data-set for harvesting patterns and themes. This research focuses on the second form of poetic inquiry as a means of praxis by using the poetry of inservice teachers, preservice teachers, and elementary students to discover themes in regard to the teaching and learning process. As literacy teacher educators, creating praxis (moving from the theoretical to the practical) remains the ultimate goal of teaching and learning experiences. We gathered poems as data-sets in order to explore the possible benefits and limitations of poetic inquiry. As we approached the notion of poetry as a form of inquiry, we probed whether this art-based inquiry might also equate educational praxis. After considering several poetry data-sets, this research provides evidence of possible benefits related to the praxis that poetry as discourse and artistic inquiry affords, and presents the caveats of the research by identifying possible limitations

Prediction of Bronchopulmonary Dysplasia by Postnatal Age in Extremely Premature Infants

Rationale: Benefits of identifying risk factors for bronchopulmonary dysplasia in extremely premature infants include providing prognostic information, identifying infants likely to benefit from preventive strategies, and stratifying infants for clinical trial enrollment