Planck pre-launch status: High Frequency Instrument polarization calibration

The High Frequency Instrument of Planck will map the entire sky in the millimeter and sub-millimeter domain from 100 to 857 GHz with unprecedented sensitivity to polarization (ΔP/T_(cmb) ~ 4 × 10^(-6) for P either Q or U and T_(cmb) ≃ 2.7 K) at 100, 143, 217 and 353 GHz. It will lead to major improvements in our understanding of the cosmic microwave background anisotropies and polarized foreground signals. Planck will make high resolution measurements of the E-mode spectrum (up to l ~ 1500) and will also play a prominent role in the search for the faint imprint of primordial gravitational waves on the CMB polarization. This paper addresses the effects of calibration of both temperature (gain) and polarization (polarization efficiency and detector orientation) on polarization measurements. The specific requirements on the polarization parameters of the instrument are set and we report on their pre-flight measurement on HFI bolometers. We present a semi-analytical method that exactly accounts for the scanning strategy of the instrument as well as the combination of different detectors. We use this method to propagate errors through to the CMB angular power spectra in the particular case of Planck-HFI, and to derive constraints on polarization parameters. We show that in order to limit the systematic error to 10% of the cosmic variance of the E-mode power spectrum, uncertainties in gain, polarization efficiency and detector orientation must be below 0.15%, 0.3% and 1° respectively. Pre-launch ground measurements reported in this paper already fulfill these requirements

Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease

Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects. Using washed membrane homogenates from the frontal cortex, hippocampus, caudate nucleus, and putamen, saturation analysis of specific receptor binding was performed for the total number of muscarinic receptors with [3H]quinuclidinyl benzilate, for muscarinic M1 receptors with [3H]pirenzepine, for muscarinic M2 receptors with [3H]oxotremorine-M, and for nicotinic receptors with (-)-[3H]nicotine. In comparison with control tissues, choline acetyl-transferase activity was reduced in the frontal cortex and hippocampus and unchanged in the caudate nucleus and putamen of parkinsonian patients. In Parkinson's disease the maximal binding site density for [3H]quinuclidinyl benzilate was increased in the frontal cortex and unaltered in the hippocampus, caudate nucleus, and putamen. Specific [3H]pirenzepine binding was increased in the frontal cortex, unaltered in the hippocampus, and decreased in the caudate nucleus and putamen. In parkinsonian patients Bmax values for specific [3H]oxotremorine-M binding were reduced in the cortex and unchanged in the hippocampus and striatum compared with controls. Maximal (-)-[3H]nicotine binding was reduced in both the cortex and hippocampus and unaltered in both the caudate nucleus and putamen. Alterations of the equilibrium dissociation constant were not observed for any ligand in any of the brain areas examined. The present results suggest that both the innominatocortical and the septohippocampal cholinergic systems degenerate in Parkinson's disease.(ABSTRACT TRUNCATED AT 250 WORDS

Generalised Umbral Moonshine

Umbral moonshine describes an unexpected relation between 23 finite groups arising from lattice symmetries and special mock modular forms. It includes the Mathieu moonshine as a special case and can itself be viewed as an example of the more general moonshine phenomenon which connects finite groups and distinguished modular objects. In this paper we introduce the notion of generalised umbral moonshine, which includes the generalised Mathieu moonshine [Gaberdiel M.R., Persson D., Ronellenfitsch H., Volpato R., Commun. Number Theory Phys. 7 (2013), 145-223] as a special case, and provide supporting data for it. A central role is played by the deformed Drinfel'd (or quantum) double of each umbral finite group $G$, specified by a cohomology class in $H^3(G,U(1))$. We conjecture that in each of the 23 cases there exists a rule to assign an infinite-dimensional module for the deformed Drinfel'd double of the umbral finite group underlying the mock modular forms of umbral moonshine and generalised umbral moonshine. We also discuss the possible origin of the generalised umbral moonshine

Terguride stimulates locomotor activity at 2 months but not 10 months after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosets

The mixed dopamine (DA) agonist/antagonist terguride acts as a DA antagonist on normosensitive receptors but shows DA agonistic properties at supersensitive DA receptors. Such a compound could offer an alternative to the treatment of Parkinson's disease with indirect or direct DA agonists. The present study compares the actions of terguride, 4-12 mg/kg i.p., in naive common marmosets with its effects in animals rendered parkinsonian by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 2 months or 10 months previously, in order to test its antiparkinsonian efficacy. Terguride reduced locomotor activity in naive common marmosets, similar to its effects in rodents and in line with the DA antagonistic activity of the compound. In marmosets treated with MPTP 2 months previously and exhibiting pronounced behavioural motor deficits, terguride stimulated locomotor activity, showing DA agonistic properties under these conditions. In contrast, the locomotor activity of animals that had recovered from MPTP treatment 10 months previously was not altered by terguride. It is concluded that terguride has anti-akinetic efficacy in this primate model of Parkinson's disease. In addition, terguride offers a unique opportunity to differentiate, pharmacologically, the extent of dopaminergic recovery from MPTP treatment in this primate species

Brain muscarinic cholinergic receptors in Huntington's disease

Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects. In comparison with controls, reductions in ChAT activity were found in the hippocampus, but not in the temporal cortex in Huntington's disease. Patients with Huntington's disease showed reduced densities of the total number of muscarinic receptors and of M-2 receptors in the hippocampus while the density of M-1 receptors was unaltered. Muscarinic receptor binding was unchanged in the temporal cortex. These results indicate a degeneration in Huntington's disease of the septo-hippocampal cholinergic pathway, but no impairment of the innominato-cortical cholinergic system

The swiss army knife of job submission tools: grid-control

Grid-control is a lightweight and highly portable open source submission tool that supports virtually all workflows in high energy physics (HEP). Since 2007 it has been used by a sizeable number of HEP analyses to process tasks that sometimes consist of up 100k jobs. grid-control is built around a powerful plugin and configuration system, that allows users to easily specify all aspects of the desired workflow. Job submission to a wide range of local or remote batch systems or grid middleware is supported. Tasks can be conveniently specified through the parameter space that will be processed, which can consist of any number of variables and data sources with complex dependencies on each other. Dataset information is processed through a configurable pipeline of dataset filters, partition plugins and partition filters. The partition plugins can take the number of files, size of the work units, metadata or combinations thereof into account. All changes to the input datasets or variables are propagated through the processing pipeline and can transparently trigger adjustments to the parameter space and the job submission. While the core functionality is completely experiment independent, integration with the CMS computing environment is provided by a small set of plugins.Comment: 8 pages, 7 figures, Proceedings for the 22nd International Conference on Computing in High Energy and Nuclear Physic

Measuring Planck beams with planets

Aims. Accurate measurement of the cosmic microwave background (CMB) anisotropy requires precise knowledge of the instrument beam. We explore how well the Planck beams will be determined from observations of planets, developing techniques that are also appropriate for other experiments. Methods. We simulate planet observations with a Planck-like scanning strategy, telescope beams, noise, and detector properties. Then we employ both parametric and non-parametric techniques, reconstructing beams directly from the time-ordered data. With a faithful parameterization of the beam shape, we can constrain certain detector properties, such as the time constants of the detectors, to high precision. Alternatively, we decompose the beam using an orthogonal basis. For both techniques, we characterize the errors in the beam reconstruction with Monte Carlo realizations. For a simplified scanning strategy, we study the impact on estimation of the CMB power spectrum. Finally, we explore the consequences for measuring cosmological parameters, focusing on the spectral index of primordial scalar perturbations, n_s. Results. The quality of the power spectrum measurement will be significantly influenced by the optical modeling of the telescope. In our most conservative case, using no information about the optics except the measurement of planets, we find that a single transit of Jupiter across the focal plane will measure the beam window functions to better than 0.3% for the channels at 100–217 GHz that are the most sensitive to the CMB. Constraining the beam with optical modeling can lead to much higher quality reconstruction. Conclusions. Depending on the optical modeling, the beam errors may be a significant contribution to the measurement systematics for n_s

The adjoint problem in the presence of a deformed surface: the example of the Rosensweig instability on magnetic fluids

The Rosensweig instability is the phenomenon that above a certain threshold of a vertical magnetic field peaks appear on the free surface of a horizontal layer of magnetic fluid. In contrast to almost all classical hydrodynamical systems, the nonlinearities of the Rosensweig instability are entirely triggered by the properties of a deformed and a priori unknown surface. The resulting problems in defining an adjoint operator for such nonlinearities are illustrated. The implications concerning amplitude equations for pattern forming systems with a deformed surface are discussed.Comment: 11 pages, 1 figur

Unification and Logarithmic Space

We present an algebraic characterization of the complexity classes Logspace and NLogspace, using an algebra with a composition law based on unification. This new bridge between unification and complexity classes is inspired from proof theory and more specifically linear logic and Geometry of Interaction. We show how unification can be used to build a model of computation by means of specific subalgebras associated to finite permutations groups. We then prove that whether an observation (the algebraic counterpart of a program) accepts a word can be decided within logarithmic space. We also show that the construction can naturally represent pointer machines, an intuitive way of understanding logarithmic space computing