29,323 research outputs found
Planck pre-launch status: High Frequency Instrument polarization calibration
The High Frequency Instrument of Planck will map the entire sky in the millimeter and sub-millimeter domain from 100 to 857 GHz with unprecedented sensitivity to polarization (ΔP/T_(cmb) ~ 4 × 10^(-6) for P either Q or U and T_(cmb) ≃ 2.7 K) at 100, 143, 217 and 353 GHz. It will lead to major improvements in our understanding of the cosmic microwave background anisotropies and polarized foreground signals. Planck will make high resolution measurements of the E-mode spectrum (up to l ~ 1500) and will also play a prominent role in the search for the faint imprint of primordial gravitational waves on the CMB polarization. This paper addresses the effects of calibration of both temperature (gain) and polarization (polarization efficiency and detector orientation) on polarization measurements. The specific requirements on the polarization parameters of the instrument are set and we report on their pre-flight measurement on HFI bolometers. We present a semi-analytical method that exactly accounts for the scanning strategy of the instrument as well as the combination of different detectors. We use this method to propagate errors through to the CMB angular power spectra in the particular case of Planck-HFI, and to derive constraints on polarization parameters. We show that in order to limit the systematic error to 10% of the cosmic variance of the E-mode power spectrum, uncertainties in gain, polarization efficiency and detector orientation must be below 0.15%, 0.3% and 1° respectively. Pre-launch ground measurements reported in this paper already fulfill these requirements
Altered muscarinic and nicotinic receptor densities in cortical and subcortical brain regions in Parkinson's disease
Muscarinic and nicotinic cholinergic receptors and choline acetyltransferase activity were studied in postmortem brain tissue from patients with histopathologically confirmed Parkinson's disease and matched control subjects. Using washed membrane homogenates from the frontal cortex, hippocampus, caudate nucleus, and putamen, saturation analysis of specific receptor binding was performed for the total number of muscarinic receptors with [3H]quinuclidinyl benzilate, for muscarinic M1 receptors with [3H]pirenzepine, for muscarinic M2 receptors with [3H]oxotremorine-M, and for nicotinic receptors with (-)-[3H]nicotine. In comparison with control tissues, choline acetyl-transferase activity was reduced in the frontal cortex and hippocampus and unchanged in the caudate nucleus and putamen of parkinsonian patients. In Parkinson's disease the maximal binding site density for [3H]quinuclidinyl benzilate was increased in the frontal cortex and unaltered in the hippocampus, caudate nucleus, and putamen. Specific [3H]pirenzepine binding was increased in the frontal cortex, unaltered in the hippocampus, and decreased in the caudate nucleus and putamen. In parkinsonian patients Bmax values for specific [3H]oxotremorine-M binding were reduced in the cortex and unchanged in the hippocampus and striatum compared with controls. Maximal (-)-[3H]nicotine binding was reduced in both the cortex and hippocampus and unaltered in both the caudate nucleus and putamen. Alterations of the equilibrium dissociation constant were not observed for any ligand in any of the brain areas examined. The present results suggest that both the innominatocortical and the septohippocampal cholinergic systems degenerate in Parkinson's disease.(ABSTRACT TRUNCATED AT 250 WORDS
Generalised Umbral Moonshine
Umbral moonshine describes an unexpected relation between 23 finite groups
arising from lattice symmetries and special mock modular forms. It includes the
Mathieu moonshine as a special case and can itself be viewed as an example of
the more general moonshine phenomenon which connects finite groups and
distinguished modular objects. In this paper we introduce the notion of
generalised umbral moonshine, which includes the generalised Mathieu moonshine
[Gaberdiel M.R., Persson D., Ronellenfitsch H., Volpato R., Commun. Number
Theory Phys. 7 (2013), 145-223] as a special case, and provide supporting data
for it. A central role is played by the deformed Drinfel'd (or quantum) double
of each umbral finite group , specified by a cohomology class in
. We conjecture that in each of the 23 cases there exists a rule
to assign an infinite-dimensional module for the deformed Drinfel'd double of
the umbral finite group underlying the mock modular forms of umbral moonshine
and generalised umbral moonshine. We also discuss the possible origin of the
generalised umbral moonshine
Terguride stimulates locomotor activity at 2 months but not 10 months after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of common marmosets
The mixed dopamine (DA) agonist/antagonist terguride acts as a DA antagonist on normosensitive receptors but shows DA agonistic properties at supersensitive DA receptors. Such a compound could offer an alternative to the treatment of Parkinson's disease with indirect or direct DA agonists. The present study compares the actions of terguride, 4-12 mg/kg i.p., in naive common marmosets with its effects in animals rendered parkinsonian by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 2 months or 10 months previously, in order to test its antiparkinsonian efficacy. Terguride reduced locomotor activity in naive common marmosets, similar to its effects in rodents and in line with the DA antagonistic activity of the compound. In marmosets treated with MPTP 2 months previously and exhibiting pronounced behavioural motor deficits, terguride stimulated locomotor activity, showing DA agonistic properties under these conditions. In contrast, the locomotor activity of animals that had recovered from MPTP treatment 10 months previously was not altered by terguride. It is concluded that terguride has anti-akinetic efficacy in this primate model of Parkinson's disease. In addition, terguride offers a unique opportunity to differentiate, pharmacologically, the extent of dopaminergic recovery from MPTP treatment in this primate species
Brain muscarinic cholinergic receptors in Huntington's disease
Muscarinic cholinergic receptors and choline acetyltransferase (ChAT) activity were studied in postmortem brain tissue from patients with Huntington's disease and matched control subjects. In comparison with controls, reductions in ChAT activity were found in the hippocampus, but not in the temporal cortex in Huntington's disease. Patients with Huntington's disease showed reduced densities of the total number of muscarinic receptors and of M-2 receptors in the hippocampus while the density of M-1 receptors was unaltered. Muscarinic receptor binding was unchanged in the temporal cortex. These results indicate a degeneration in Huntington's disease of the septo-hippocampal cholinergic pathway, but no impairment of the innominato-cortical cholinergic system
The swiss army knife of job submission tools: grid-control
Grid-control is a lightweight and highly portable open source submission tool
that supports virtually all workflows in high energy physics (HEP). Since 2007
it has been used by a sizeable number of HEP analyses to process tasks that
sometimes consist of up 100k jobs. grid-control is built around a powerful
plugin and configuration system, that allows users to easily specify all
aspects of the desired workflow. Job submission to a wide range of local or
remote batch systems or grid middleware is supported. Tasks can be conveniently
specified through the parameter space that will be processed, which can consist
of any number of variables and data sources with complex dependencies on each
other. Dataset information is processed through a configurable pipeline of
dataset filters, partition plugins and partition filters. The partition plugins
can take the number of files, size of the work units, metadata or combinations
thereof into account. All changes to the input datasets or variables are
propagated through the processing pipeline and can transparently trigger
adjustments to the parameter space and the job submission. While the core
functionality is completely experiment independent, integration with the CMS
computing environment is provided by a small set of plugins.Comment: 8 pages, 7 figures, Proceedings for the 22nd International Conference
on Computing in High Energy and Nuclear Physic
Measuring Planck beams with planets
Aims. Accurate measurement of the cosmic microwave background (CMB) anisotropy requires precise knowledge of the instrument beam. We explore how well the Planck beams will be determined from observations of planets, developing techniques that are also appropriate for other experiments.
Methods. We simulate planet observations with a Planck-like scanning strategy, telescope beams, noise, and detector properties. Then we employ both parametric and non-parametric techniques, reconstructing beams directly from the time-ordered data. With a faithful parameterization of the beam shape, we can constrain certain detector properties, such as the time constants of the detectors, to high precision. Alternatively, we decompose the beam using an orthogonal basis. For both techniques, we characterize the errors in the beam reconstruction with Monte Carlo realizations. For a simplified scanning strategy, we study the impact on estimation of the CMB power spectrum. Finally, we explore the consequences for measuring cosmological parameters, focusing on the spectral index of primordial scalar perturbations, n_s.
Results. The quality of the power spectrum measurement will be significantly influenced by the optical modeling of the telescope. In our most conservative case, using no information about the optics except the measurement of planets, we find that a single transit of Jupiter across the focal plane will measure the beam window functions to better than 0.3% for the channels at 100–217 GHz that are the most sensitive to the CMB. Constraining the beam with optical modeling can lead to much higher quality reconstruction.
Conclusions. Depending on the optical modeling, the beam errors may be a significant contribution to the measurement systematics for n_s
The adjoint problem in the presence of a deformed surface: the example of the Rosensweig instability on magnetic fluids
The Rosensweig instability is the phenomenon that above a certain threshold
of a vertical magnetic field peaks appear on the free surface of a horizontal
layer of magnetic fluid. In contrast to almost all classical hydrodynamical
systems, the nonlinearities of the Rosensweig instability are entirely
triggered by the properties of a deformed and a priori unknown surface. The
resulting problems in defining an adjoint operator for such nonlinearities are
illustrated. The implications concerning amplitude equations for pattern
forming systems with a deformed surface are discussed.Comment: 11 pages, 1 figur
Unification and Logarithmic Space
We present an algebraic characterization of the complexity classes Logspace
and NLogspace, using an algebra with a composition law based on unification.
This new bridge between unification and complexity classes is inspired from
proof theory and more specifically linear logic and Geometry of Interaction.
We show how unification can be used to build a model of computation by means
of specific subalgebras associated to finite permutations groups. We then prove
that whether an observation (the algebraic counterpart of a program) accepts a
word can be decided within logarithmic space. We also show that the
construction can naturally represent pointer machines, an intuitive way of
understanding logarithmic space computing
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