La navigation des ports français en Méditerranée au xviiie siècle: premiers aperçus à partir d’une source inexploitée

Au cours de la réalisation d’un inventaire intégral de la sous-série G5 du fonds de l’Amirauté conservée aux Archives Nationales de Paris, nous avons trouvé une série de tableaux statistiques fournissant des indications détaillées sur le mouvement portuaire de toutes les amirautés françaises en Méditerranée des années 1730 au début des années 1790. Cet article présente ce fonds et livre une première analyse de l’évolution de la navigation dans ces ports.While working at a new finding aid of the sub-series G5 of the Admiralty kept at the National Archives in Paris, we found a series of statistical tables providing detailed data on shipping in all the French admiralties offices in the French Mediterranean from the 1730s to the early 1790s. This paper presents this source and provides a first sight into the evolution of shipping in these ports

La navigation des ports français en Méditerranée au xviiie siècle: premiers aperçus à partir d’une source inexploitée

Au cours de la réalisation d’un inventaire intégral de la sous-série G5 du fonds de l’Amirauté conservée aux Archives Nationales de Paris, nous avons trouvé une série de tableaux statistiques fournissant des indications détaillées sur le mouvement portuaire de toutes les amirautés françaises en Méditerranée des années 1730 au début des années 1790. Cet article présente ce fonds et livre une première analyse de l’évolution de la navigation dans ces ports.While working at a new finding aid of the sub-series G5 of the Admiralty kept at the National Archives in Paris, we found a series of statistical tables providing detailed data on shipping in all the French admiralties offices in the French Mediterranean from the 1730s to the early 1790s. This paper presents this source and provides a first sight into the evolution of shipping in these ports

Durability of bioprosthetic aortic valves in patients under the age of 60 years - Rationale and design of the international INDURE registry

Background: There is an ever-growing number of patients requiring aortic valve replacement (AVR). Limited data is available on the long-term outcomes and structural integrity of bioprosthetic valves in younger patients undergoing surgical AVR. Methods: The INSPIRIS RESILIA Durability Registry (INDURE) is a prospective, open-label, multicentre, international registry with a follow-up of 5 years to assess clinical outcomes of patients younger than 60 years who undergo surgical AVR using the INSPIRIS RESILIA aortic valve. INDURE will be conducted across 20-22 sites in Europe and Canada and intends to enrol minimum of 400 patients. Patients will be included if they are scheduled to undergo AVR with or without concomitant root replacement and/or coronary bypass surgery. The primary objectives are to 1) determine VARC-2 defined time-related valve safety at one-year (depicted as freedom from events) and 2) determine freedom from stage 3 structural valve degeneration (SVD) presenting as morphological abnormalities and severe haemodynamic valve degeneration at 5 years. Secondary objectives include the assessment of the haemodynamic performance of the valve, all stages of SVD, potential valve-in-valve procedures, clinical outcomes (in terms of New York Heart Association [NYHA] function class and freedom from valve-related rehospitalisation) and change in patient quality-of-life. Discussion: INDURE is a prospective, multicentre registry in Europe and Canada, which will provide much needed data on the long-term performance of bioprosthetic valves in general and the INSPIRIS RESILIA valve in particular. The data may help to gather a deeper understanding of the longevity of bioprosthetic valves and may expand the use of bioprosthetic valves in patients under the age of 60 years. Trial registration: ClinicalTrials.gov identifier: NCT03666741 (registration received September, 12th, 2018)

Durability of bioprosthetic aortic valve replacement in patients under the age of 60 years - 1-year follow-up from the prospective INDURE registry.

OBJECTIVES We report 1-year safety and clinical outcomes in patients <60 years undergoing bioprosthetic surgical aortic valve intervention. METHODS The INSPIRIS RESILIA Durability Registry (INDURE) is a prospective, multicentre registry to assess clinical outcomes of patients <60 years. Patients with planned SAVR with or without concomitant replacement of the ascending aorta and/or coronary bypass surgery were included. Time-related valve safety, haemodynamic performance, and quality of life (QoL) at 1 year were assessed. RESULTS 421 patients were documented with a mean age of 53.5 years, 76.5% being male, and 27.2% in NYHA class III/IV. Outcomes within 30 days included cardiovascular-related mortality (0.7%), time-related valve safety (VARC-2; 5.8%), thromboembolic events (1.7%), valve-related life-threatening bleeding (VARC-2; 4.3%), and permanent pacemaker implantation (3.8%). QoL was significantly increased at 6 months and sustained at 1 year. Freedom from all-cause mortality at 1 year was 98.3% (95%CI 97.1;99.6) and 81.8% were NYHA I vs. 21.9% at baseline. No patient developed structural valve deterioration Stage 3 (VARC-3). Mean aortic pressure gradient was 12.6 mmHg at 1 year and effective orifice area was 1.9 cm2. CONCLUSIONS The 1-year data from the INSPIRIS RESILIA valve demonstrate good safety and excellent haemodynamic performance as well as an early QoL improvement. CLINICALTRIALS NUMBER NCT03666741

Concomitant ablation of atrial fibrillation in octogenarians: an observational study

<p>Abstract</p> <p>Background</p> <p>Cardiac surgery is increasingly required in octogenarians. These patients frequently present atrial fibrillation (AF), a significant factor for stroke and premature death. During the last decade, AF ablation has become an effective procedure in cardiac surgery. Because the results of concomitant AF ablation in octogenarians undergoing cardiac surgery are still not clear, we evaluated the outcome in these patients.</p> <p>Methods</p> <p>Among 200 patients undergoing concomitant AF ablation (87% persistent AF), 28 patients were ≥ 80 years (82 ± 2.4 years). The outcome was analysed by prospective follow up after 3, 6, 12 months and annually thereafter. Freedom from AF was calculated according to the Kaplan-Meier method.</p> <p>Results</p> <p>Octogenarians were similar to controls regarding AF duration (48 ± 63.2 versus 63 ± 86.3 months, n.s.) and left atrial diameter (49 ± 6.1 versus 49 ± 8.8 mm, n.s.), but differed in EuroSCORE (17.3 ± 10.93 versus 7.4 ± 7.31%, p < 0.001), prevalence of paroxysmal AF (25.0 versus 11.0%, p = 0.042) and aortic valve disease (67.8 versus 28.5%, p < 0.001). ICU stay (8 ± 16.9 versus 4 ± 7.2 days, p = 0.027), hospital stay (20 ± 23.9 versus 14 ± 30.8 days, p < 0.05), and 30-d-mortality (14.3 versus 4.6%, p = 0.046) were increased. After 12 ± 6.1 months of follow-up (95% complete), 14 octogenarians (82%) and 101 controls (68%, n.s.) were in sinus rhythm; 59% without antiarrhythmic drugs in either group (n.s.). Sinus rhythm restoration was associated with improved NYHA functional class and renormalization of left atrial size. Cumulative freedom from AF demonstrated no difference between groups. Late mortality was higher in octogenarians (16.7 versus 6.1%, p = 0.065).</p> <p>Conclusion</p> <p>Sinus rhythm restoration rate and functional improvement are satisfactory in octogenarians undergoing concomitant AF ablation. Hence, despite an increased perioperative risk, this procedure should be considered even in advanced age.</p

Durability of bioprosthetic aortic valves in patients under the age of 60 years - Rationale and design of the international INDURE registry

Background: There is an ever-growing number of patients requiring aortic valve replacement (AVR). Limited data is available on the long-term outcomes and structural integrity of bioprosthetic valves in younger patients undergoing surgical AVR. Methods: The INSPIRIS RESILIA Durability Registry (INDURE) is a prospective, open-label, multicentre, international registry with a follow-up of 5 years to assess clinical outcomes of patients younger than 60 years who undergo surgical AVR using the INS

Vascular relaxation of canine visceral arteries after ischemia by means of supraceliac aortic cross-clamping followed by reperfusion

<p>Abstract</p> <p>Background</p> <p>The supraceliac aortic cross-clamping can be an option to save patients with hipovolemic shock due to abdominal trauma. However, this maneuver is associated with ischemia/reperfusion (I/R) injury strongly related to oxidative stress and reduction of nitric oxide bioavailability. Moreover, several studies demonstrated impairment in relaxation after I/R, but the time course of I/R necessary to induce vascular dysfunction is still controversial. We investigated whether 60 minutes of ischemia followed by 30 minutes of reperfusion do not change the relaxation of visceral arteries nor the plasma and renal levels of malondialdehyde (MDA) and nitrite plus nitrate (NOx).</p> <p>Methods</p> <p>Male mongrel dogs (n = 27) were randomly allocated in one of the three groups: sham (no clamping, n = 9), ischemia (supraceliac aortic cross-clamping for 60 minutes, n = 9), and I/R (60 minutes of ischemia followed by reperfusion for 30 minutes, n = 9). Relaxation of visceral arteries (celiac trunk, renal and superior mesenteric arteries) was studied in organ chambers. MDA and NOx concentrations were determined using a commercially available kit and an ozone-based chemiluminescence assay, respectively.</p> <p>Results</p> <p>Both acetylcholine and calcium ionophore caused relaxation in endothelium-intact rings and no statistical differences were observed among the three groups. Sodium nitroprusside promoted relaxation in endothelium-denuded rings, and there were no inter-group statistical differences. Both plasma and renal concentrations of MDA and NOx showed no significant difference among the groups.</p> <p>Conclusion</p> <p>Supraceliac aortic cross-clamping for 60 minutes alone and followed by 30 minutes of reperfusion did not impair relaxation of canine visceral arteries nor evoke biochemical alterations in plasma or renal tissue.</p

Private trade and monopoly structures : the East India Companies and the commodity trade to Europe in the eighteenth century

Our research is about the trade in material goods from Asia to Europe over this period, and its impact on Europe’s consumer and industrial cultures. It entails a comparative study of Europe’s East India Companies and the private trade from Asia over the period. The commodities trade was heavily dependent on private trade. The historiography to date has left a blind spot in this area, concentrating instead on corruption and malfeasance. Taking a global history approach we investigate the trade in specific consumer goods in many qualities and varieties that linked merchant communities and stimulated information flows. We set out how private trade functioned alongside and in connection with the various European East India companies; we investigate how this changed over time, how it drew on the Company infrastructure, and how it took the risks and developed new and niche markets for specific Asian commodities that the Companies could not sustain

Quantification des incertitudes d'une exploitation d'un gisement d'uranium par Récupération In Situ

Uranium In Situ Recovery (ISR) is based on the direct leaching of the uranium ore in the deposit by a mining solution. Fluid flow and geochemical reaction in the reservoir are difficult to predict due to geological, petrophysical and geochemical uncertainties. The reactive transport simulation code used to model ISR is very sensitive to the spatial distribution of the physical and chemical properties of the deposit. Geostatistical models are used to represent the uncertainty of the spatial distribution of geological properties. The direct propagation of geological uncertainties by multiple ISR mining simulations is intractable in an industrial context. This work presents a way to propagate geological uncertainties into uranium production uncertainties at a reduced computational cost, thanks to a scenario reduction method. A subset of geostatistical simulations is built to approximate the variability of a larger set. The selection is obtained using a proxy of reactive transport simulation. The main contribution of this work is the development of different proxys to approximate the uranium leaching. They allow the discrimination of geostatistical realizations in terms of potential uranium production.Then, the ISR simulation carried out with the selected geostatistical realizations gives an approximation of the uranium production variability over the whole set of geostatistical simulations. This approximation is then used to quantify the uncertainties on the uranium production. The proposed approach is assessed on real case studies. Finally, the propagation of the uranium production uncertainty, assessed by the scenario reduction method, on mining operation planning is developped. Furthermore, an exploratory work about the use of statistical meta-models as chemistry solvers is also presented.La Lixiviation In-Situ d’uranium, ou In-Situ Recovery (ISR), est basée sur la lixiviation directe des minéraux uranifères au coeur du gisement par une solution minière injectée. Les résultats des écoulements et des réactions chimiques dans le réservoir sont difficiles à prédire en raison des incertitudes géochimiques, pétrophysiques et géologiques. Les codes de simulation de transport réactif utilisés pour modéliser l’ISR sont particulièrement sensibles à la distribution spatiale des propriétés physiques et chimiques dans le dépôt. Ainsi, la modélisation géostatistique est utilisée pour représenter l’incertitude de la répartition spatiale des propriétés géologiques. On peut représenter cette incertitude par un grand nombre de réalisations du modèle géostatistique. La propagation directe des incertitudes géologiques est difficile à résoudre en contexte industriel en raison du temps CPU nécessaire pour effectuer une simulation de l’ISR. Les travaux réalisés dans cette thèse présentent différents moyens de propager l’incertitude géologique en incertitude sur la production d’uranium avec un coût en temps de calcul réduit. On utilise pour cela la méthode de réduction de scénarios, qui permet de propager parcimonieusement l’incertitude. Un sous-ensemble de simulations géostatistiques est sélectionné pour approximer la variabilité d’un ensemble plus large. La sélection est obtenue en utilisant un proxy de la simulation de transport réactif. La principale contribution de ce travail est la construction de différents proxys pour approximer la lixiviation de l’uranium. Ils permettent de reproduire la dissimilarité des réalisations en terme de production d’uranium. Ensuite, les simulations de l’ISR effectuées dans les réalisations géostatistiques sélectionnées donnent une approximation de la variabilité de production d’uranium de l’ensemble des réalisations. Cette approximation est enfin utilisée pour quantifier les incertitudes de la production d’uranium sur des cas réels. Finalement, la propagation de l’incertitude de production de l’échelle du bloc de production à l’échelle de la mine est développée. Par ailleurs, un travail exploratoire a été mené dans le but d’utiliser des modèles de substitution du solveur de la chimie pour accélérer les simulations de transport réactif