658 research outputs found
Radio-responsive recA promoter significantly increases TNF alpha production in recombinant clostridia after 2 Gy irradiation
Specific targeting of cytosine deaminase to solid tumors by engineered Clostridium acetobutylicum
Flow cytometric characterization of freshly isolated and culture expanded human synovial cell populations in patients with chronic arthritis
A Golf Programme for People with Severe and Enduring Mental Health Problems
This article reports a pioneering golf programme for people with severe and enduring mental health problems. Following a discussion of the problems and possibilities of golf as a form of physical activity for this group, we outline the structure, organisation, and ethos of the golf programme. Through an analysis of qualitative case study data collected during the programme, we discuss the response to the programme from service users and mental health professionals. We conclude by highlighting aspects of the programme which were critical to its success and offering suggestions for further initiatives in this area
In vivo antitumor effect of vascular targeting combined with either ionizing radiation or anti-angiogenesis treatment
Colonisation of Clostridium in the body is restricted to hypoxic and necrotic areas of tumours
The use of gene therapy is one of the most recent molecular strategies for the treatment of cancer. It is essential, however, to have an efficient transfer system by which the desired gene can be delivered to the correct environment. The experiments described in this report investigate apathogenic Clostridium as a possible vector to transfer a specific gene product into the extracellular microenvironment of the tumour which is hypoxic/necrotic in parts, using WAG/Rij rats with transplantable rhabdomyosarcomas as a model. Our data show that Clostridium, after systemic administration of at least 10(7) spores, specifically colonises the hypoxic/necrotic areas of our tumour model, the most efficient species being C. acetobutylicum (NI-4082) and C. oncolyticum. Although spores were also detected in normal tissues for up to 4 weeks, they did not germinate in these tissues. We conclude that it seems likely that these bacteria can be used as a selective transfer system into the extracellular environment of tumours which have hypoxic regions. This strategy would be more tumour-specific than various other strategies that are currently being investigated in anti-cancer gene therapy. (C) 1998 Academic Press.</p
Herziening van de indeling in ecologische soortengroepen voor Nederland en Vlaanderen
Herziening van de indeling, zoals die in 1987 werd gepresenteerd (Gorteria, vol. 13, pp. 277-359
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