Evaluation of the Atlas of Honduras (Atlas Mitch)

In October 1998, the Seeds of Hope project contributed to the production of 2,000 copies of the “Mitch Atlas”, containing fundamental maps on population, land use, roads, rivers, topography, and soils. The Atlas was freely distributed to institutions for post-Hurricane Mitch emergency response and reconstruction. Two years later, the Seeds of Hope project conducted an impact assessment of the Atlas in order to gauge the role of geographic information on decision-making. The results of this impact assessment are presented in this report. The methods used to assess the impact of the Atlas combined case study analysis and descriptive statistics. We interviewed 20 Atlas users and received 43 completed questionnaires. Based on user responses, the Atlas of Honduras made a significant contribution to disaster response, agricultural development, and natural resource management in Honduras. Overall, 97.7% of the respondents said they thought the Atlas was a useful tool, and 84.8% thought the Atlas was the best compilation of geographic information available in Honduras. Seventy four percent of the respondents found the Atlas easy to use, and 90.5% used the Atlas interface itself, rather than copying the data to be used with their own GIS software. This indicates that the interface itself was well designed. The Atlas was used for a range of applications, from basic mapping to more strategic planning, predominantly within the agricultural and natural resources management sectors. Nearly all those who participated in this evaluation indicated that the Atlas improved the quality and efficiency of decision-making. However, a number of Atlas users mentioned that the Atlas was one of a range of tools and information sources, so they were reluctant to assert that the Atlas had a direct impact on their decision-making. The Atlas was instrumental in raising awareness of the value of geographic information and need to share information. With the Atlas now 2 years old, 100% of the users sampled expressed an interest in having an updated version produced, and 92.7% said they would be willing to contribute to it. 88.1% of the sampled users said they expect to use geographic information frequently in the next five years, indicating that geographic information will have a prominent role in the future

Solving non-uniqueness in agglomerative hierarchical clustering using multidendrograms

In agglomerative hierarchical clustering, pair-group methods suffer from a problem of non-uniqueness when two or more distances between different clusters coincide during the amalgamation process. The traditional approach for solving this drawback has been to take any arbitrary criterion in order to break ties between distances, which results in different hierarchical classifications depending on the criterion followed. In this article we propose a variable-group algorithm that consists in grouping more than two clusters at the same time when ties occur. We give a tree representation for the results of the algorithm, which we call a multidendrogram, as well as a generalization of the Lance and Williams' formula which enables the implementation of the algorithm in a recursive way.Comment: Free Software for Agglomerative Hierarchical Clustering using Multidendrograms available at http://deim.urv.cat/~sgomez/multidendrograms.ph

Isolating a light Higgs boson from the di-photon background at the LHC

We compute the QCD corrections to the gluon fusion subprocess gg to gamma gamma, which forms an important component of the background to the search for a light Higgs boson at the LHC. We study the dependence of the improved pp to gamma gamma X background calculation on the factorization and renormalization scales, on various choices for photon isolation cuts, and on the rapidities of the photons. We also investigate ways to enhance the statistical significance of the Higgs signal in the di-photon channel.Comment: Additional reference included, 17 pages, 16 figure files, revte

Two-Loop Helicity Amplitudes for Quark-Gluon Scattering in QCD and Gluino-Gluon Scattering in Supersymmetric Yang-Mills Theory

We present the two-loop QCD helicity amplitudes for quark-gluon scattering, and for quark-antiquark annihilation into two gluons. These amplitudes are relevant for next-to-next-to-leading order corrections to (polarized) jet production at hadron colliders. We give the results in the `t Hooft-Veltman and four-dimensional helicity (FDH) variants of dimensional regularization. The transition rules for converting the amplitudes between the different variants are much more intricate than for the previously discussed case of gluon-gluon scattering. Summing our two-loop expressions over helicities and colors, and converting to conventional dimensional regularization, gives results in complete agreement with those of Anastasiou, Glover, Oleari and Tejeda-Yeomans. We describe the amplitudes for 2 to 2 scattering in pure N=1 supersymmetric Yang-Mills theory, obtained from the QCD amplitudes by modifying the color representation and multiplicities, and verify supersymmetry Ward identities in the FDH scheme.Comment: 77 pages. v2: corrected errors in eqs. (3.7) and (3.8) for one-loop assembly; remaining results unaffecte

Human endogenous retrovirus transcription profiles of the kidney and kidney-derived cell lines.

The human genome comprises approximately 8-9 % of human endogenous retroviruses (HERVs) that are transcribed with tissue specificity. However, relatively few organs have been examined in detail for individual differences in HERV transcription pattern, nor have tissue-to-cell culture comparisons been frequently performed. Using an HERV-specific DNA microarray, a core HERV transcription profile was established for the human kidney comparing 10 tissue samples. This core represents HERV groups expressed uniformly or nearly so in non-tumour kidney tissue. The profiles obtained from non-tumour tissues were compared to 10 renal tumour tissues (renal cell carcinoma, RCC) derived from the same individuals and additionally, to 22 RCC cell lines. No RCC cell line or tumour-specific differences were observed, suggesting that HERV transcription is not altered in RCC. However, when comparing tissue transcription to cell line transcription, there were consistent differences. The differences were irrespective of cancer state and included cell lines derived from non-tumour kidney tissue, suggesting that a specific alteration of HERV transcription occurs when establishing cell lines. In contrast to previous publications, all known HERV-derived tumour antigens, including those identified in RCC, were expressed both in multiple RCC cell lines and several non-tumour tissue-derived cell lines, a result that contrasts with findings from patient samples. The results establish the core kidney transcription pattern of HERVs and reveal differences between cell culture lines and tissue samples

Time Lags between Exanthematous Illness Attributed to Zika Virus, Guillain-Barré Syndrome, and Microcephaly, Salvador, Brazil

Zika virus infection emerged as a public health emergency after increasing evidence for its association with neurologic disorders and congenital malformations. In Salvador, Brazil, outbreaks of acute exanthematous illness (AEI) attributed to Zika virus, Guillain-Barré syndrome (GBS), and microcephaly occurred in 2015. We investigated temporal correlations and time lags between these outbreaks to identify a common link between them by using epidemic curves and time series cross-correlations. Number of GBS cases peaked after a lag of 5–9 weeks from the AEI peak. Number of suspected cases of microcephaly peaked after a lag of 30–33 weeks from the AEI peak, which corresponded to time of potential infections of pregnant mothers during the first trimester. These findings support the association of GBS and microcephaly with Zika virus infection and provide evidence for a temporal relationship between timing of arboviral infection of pregnant women during the first trimester and birth outcome