Inertial waves and modes excited by the libration of a rotating cube

We report experimental measurements of the flow in a cubic container submitted to a longitudinal libration, i.e. a rotation modulated in time. Velocity fields in a vertical and a horizontal plane are measured in the librating frame using a corotating particle image velocimetry system. When the libration frequency $\sigma_0$ is smaller than twice the mean rotation rate $\Omega_0$, inertial waves can propagate in the interior of the fluid. At arbitrary excitation frequencies $\sigma_0<2\Omega_0$, the oscillating flow shows two contributions: (i) a basic flow induced by the libration motion, and (ii) inertial wave beams propagating obliquely upward and downward from the horizontal edges of the cube. In addition to these two contributions, inertial modes may also be excited at some specific resonant frequencies. We characterize in particular the resonance of the mode of lowest order compatible with the symmetries of the forcing, noted [2,1,+]. By comparing the measured flow fields to the expected inviscid inertial modes computed numerically [L.R.M. Maas, Fluid Dyn. Res. \textbf{33}, 373 (2003)], we show that only a subset of inertial modes, matching the symmetries of the forcing, can be excited by the libration.Comment: Phys. Fluids (in press

Aerodynamics in the open channel of the Sistan-type wind-mill with vertical axis wind turbine

International Journal of Numerical Methods for Heat and Fluid FlowThe purpose of this paper is to examine the details of the air mass flow and aerodynamical phenoména across a channel containing a large vertical axis wind turbine. The considered model reproduces as closely as possible the real assembly of the Sistan-type wind-mill whose top is open. The technical results of this work could be used for the restoration and operation of this assembly whose historical and architectural values are recognized.L'objectif de cet article est d’examiner les détails d'un écoulement dans un canal contenant une turbine à axe vertical. Les résultats techniques de ce travail pourront être utilisés pour la restauration et la mise en service de ce dispositif dont la valeur historique et architecturale est reconnue

Large-Eddy Simulations of Magnetohydrodynamic Turbulence in Heliophysics and Astrophysics

We live in an age in which high-performance computing is transforming the way we do science. Previously intractable problems are now becoming accessible by means of increasingly realistic numerical simulations. One of the most enduring and most challenging of these problems is turbulence. Yet, despite these advances, the extreme parameter regimes encountered in space physics and astrophysics (as in atmospheric and oceanic physics) still preclude direct numerical simulation. Numerical models must take a Large Eddy Simulation (LES) approach, explicitly computing only a fraction of the active dynamical scales. The success of such an approach hinges on how well the model can represent the subgrid-scales (SGS) that are not explicitly resolved. In addition to the parameter regime, heliophysical and astrophysical applications must also face an equally daunting challenge: magnetism. The presence of magnetic fields in a turbulent, electrically conducting fluid flow can dramatically alter the coupling between large and small scales, with potentially profound implications for LES/SGS modeling. In this review article, we summarize the state of the art in LES modeling of turbulent magnetohydrodynamic (MHD) ows. After discussing the nature of MHD turbulence and the small-scale processes that give rise to energy dissipation, plasma heating, and magnetic reconnection, we consider how these processes may best be captured within an LES/SGS framework. We then consider several special applications in heliophysics and astrophysics, assessing triumphs, challenges,and future directions

Damping inertial modes excitation in a closed grid turbulence experiment under rotation

We report an experimental study of the decay of grid-generated turbulence in a confined geometry submitted to a global rotation. Turbulence is generated by rapidly towing a grid in a parallelepipedic water tank. The velocity fields of a large number of independent decays are measured in a vertical plane parallel to the rotation axis using a corotating Particle Image Velocimetry system. We first show that, when a “simple” grid is used, a significant amount of the kinetic energy (typically 50%) is stored in a reproducible flow composed of resonant inertial modes. The possible coupling between these modes and turbulence suggests that turbulence cannot be considered as freely decaying in this configuration. We demonstrate however that these inertial modes may be significantly reduced (down to 15% of the total energy) by adding a set of inner tanks attached to the grid. These results suggest that it is possible to produce an effectively freely decaying rotating turbulence in a confined geometry

Alterations in Ca2+ Signalling via ER-mitochondria contact site remodelling in cancer

Inter-organellar contact sites establish microdomains for localised Ca2+-signalling events. One of these microdomains is established between the ER and the mitochondria. Importantly, the so-called mitochondria-associated ER membranes (MAMs) contain, besides structural proteins and proteins involved in lipid exchange, several Ca2+-transport systems, mediating efficient Ca2+ transfer from the ER to the mitochondria. These Ca2+ signals critically control several mitochondrial functions, thereby impacting cell metabolism, cell death and survival, proliferation and migration. Hence, the MAMs have emerged as critical signalling hubs in physiology, while their dysregulation is an important factor that drives or at least contributes to oncogenesis and tumour progression. In this book chapter, we will provide an overview of the role of the MAMs in cell function and how alterations in the MAM composition contribute to oncogenic features and behaviours