825 research outputs found
Dynamical Casimir Effect in a Designed Leaky Cavity
The phenomenon of particle creation within a resonantly vibrating lossy
cavity is investigated for the example of a massless scalar field at finite
temperature. Leakage is provided by insertion of a dispersive mirror into a
larger ideal cavity. Via the rotating wave approximation we demonstrate that
for the case of parametric resonance the exponential growth of the number of
created particles and the strong enhancement at finite temperatures are
preserved in the presence of reasonable losses. The relevance for experimental
tests of quantum radiation via the dynamical Casimir effect is addressed.Comment: 1 figur
Dynamical Casimir effect at finite temperature
Thermal effects on the creation of particles under the influence of
time-dependent boundary conditions are investigated. The dominant temperature
correction to the energy radiated by a moving mirror is derived by means of
response theory. For a resonantly vibrating cavity the thermal effect on the
number of created photons is obtained non-perturbatively. Finite temperatures
can enhance the pure vacuum effect by several orders of magnitude. The
relevance of finite temperature effects for the experimental verification of
the dynamical Casimir effect is addressed.Comment: 9 LaTex page
Observation of the Dynamical Casimir Effect in a Superconducting Circuit
One of the most surprising predictions of modern quantum theory is that the
vacuum of space is not empty. In fact, quantum theory predicts that it teems
with virtual particles flitting in and out of existence. While initially a
curiosity, it was quickly realized that these vacuum fluctuations had
measurable consequences, for instance producing the Lamb shift of atomic
spectra and modifying the magnetic moment for the electron. This type of
renormalization due to vacuum fluctuations is now central to our understanding
of nature. However, these effects provide indirect evidence for the existence
of vacuum fluctuations. From early on, it was discussed if it might instead be
possible to more directly observe the virtual particles that compose the
quantum vacuum. 40 years ago, Moore suggested that a mirror undergoing
relativistic motion could convert virtual photons into directly observable real
photons. This effect was later named the dynamical Casimir effect (DCE). Using
a superconducting circuit, we have observed the DCE for the first time. The
circuit consists of a coplanar transmission line with an electrical length that
can be changed at a few percent of the speed of light. The length is changed by
modulating the inductance of a superconducting quantum interference device
(SQUID) at high frequencies (~11 GHz). In addition to observing the creation of
real photons, we observe two-mode squeezing of the emitted radiation, which is
a signature of the quantum character of the generation process.Comment: 12 pages, 3 figure
Dynamical Casimir Effect in a Leaky Cavity at Finite Temperature
The phenomenon of particle creation within an almost resonantly vibrating
cavity with losses is investigated for the example of a massless scalar field
at finite temperature. A leaky cavity is designed via the insertion of a
dispersive mirror into a larger ideal cavity (the reservoir). In the case of
parametric resonance the rotating wave approximation allows for the
construction of an effective Hamiltonian. The number of produced particles is
then calculated using response theory as well as a non-perturbative approach.
In addition we study the associated master equation and briefly discuss the
effects of detuning. The exponential growth of the particle numbers and the
strong enhancement at finite temperatures found earlier for ideal cavities turn
out to be essentially preserved. The relevance of the results for experimental
tests of quantum radiation via the dynamical Casimir effect is addressed.
Furthermore the generalization to the electromagnetic field is outlined.Comment: 48 pages, 8 figures typos corrected & references added and update
Trembling cavities in the canonical approach
We present a canonical formalism facilitating investigations of the dynamical
Casimir effect by means of a response theory approach. We consider a massless
scalar field confined inside of an arbitaray domain , which undergoes
small displacements for a certain period of time. Under rather general
conditions a formula for the number of created particles per mode is derived.
The pertubative approach reveals the occurance of two generic processes
contributing to the particle production: the squeezing of the vacuum by
changing the shape and an acceleration effect due to motion af the boundaries.
The method is applied to the configuration of moving mirror(s). Some properties
as well as the relation to local Green function methods are discussed.
PACS-numbers: 12.20; 42.50; 03.70.+k; 42.65.Vh Keywords: Dynamical Casimir
effect; Moving mirrors; Cavity quantum field theory; Vibrating boundary
Acetylcholine receptors (muscarinic) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
Muscarinic acetylcholine receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [45]) are GPCRs of the Class A, rhodopsin-like family where the endogenous agonist is acetylcholine. In addition to the agents listed in the table, AC-42, its structural analogues AC-260584 and 77-LH-28-1, N-desmethylclozapine, TBPB and LuAE51090 have been described as functionally selective agonists of the M1 receptor subtype via binding in a mode distinct from that utilized by non-selective agonists [243, 242, 253, 155, 154, 181, 137, 11, 230]. There are two pharmacologically characterised allosteric sites on muscarinic receptors, one defined by it binding gallamine, strychnine and brucine, and the other defined by the binding of KT 5720, WIN 62,577, WIN 51,708 and staurosporine [161, 162]
Acetylcholine receptors (muscarinic) in GtoPdb v.2021.3
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [50]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for many disorders. Functionally, M1, M3, and M5 mAChRs preferentially couple to Gq/11 proteins, whilst M2 and M4 mAChRs predominantly couple to Gi/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic agents such as organophosphates
Acetylcholine receptors (muscarinic) in GtoPdb v.2023.1
Muscarinic acetylcholine receptors (mAChRs) (nomenclature as agreed by the NC-IUPHAR Subcommittee on Muscarinic Acetylcholine Receptors [53]) are activated by the endogenous agonist acetylcholine. All five (M1-M5) mAChRs are ubiquitously expressed in the human body and are therefore attractive targets for many disorders. Functionally, M1, M3, and M5 mAChRs preferentially couple to Gq/11 proteins, whilst M2 and M4 mAChRs predominantly couple to Gi/o proteins. Both agonists and antagonists of mAChRs are clinically approved drugs, including pilocarpine for the treatment of elevated intra-ocular pressure and glaucoma, and atropine for the treatment of bradycardia and poisoning by muscarinic agents such as organophosphates. Of note, it has been observed that mAChRs dimerise reversibly [134] and that dimerisation/oligomerisation can be affected by ligands [183, 196]
Density correlations and dynamical Casimir emission of Bogoliubov phonons in modulated atomic Bose-Einstein condensates
We present a theory of the density correlations that appear in an atomic
Bose-Einstein condensate as a consequence of the dynamical Casimir emission of
pairs of Bogoliubov phonons when the atom-atom scattering length is modulated
in time. Different regimes as a function of the temporal shape of the
modulation are identified and a simple physical picture of the phenomenon is
discussed. Analytical expressions for the density correlation function are
provided for the most significant limiting cases. This theory is able to
explain some unexpected features recently observed in numerical calculations of
Hawking radiation from analog black holes
- …