France and Language(s): Old Policies and New Challenges in Education. Towards a Renewed Framework?

Article de synthèse publié dans le yearbook du CIDREEThis article is concerned with the way the French education system deals with new challenges in terms of language, while referring to the (traditional) general framework of language planning in the country. The same principles and mindset that governed the way regional minority languages were treated in the past are now largely determining the way the languages of immigrants and their speakers are treated and considered. We thus seek to remind readers how the theoretical and practical background to language planning in education functions in France, showing how historical factors led to considering linguistic diversity as an unnecessary heritage rather than as an asset. We then move on to examine the state of language teaching generally speaking in the education system, in order to provide a general outlook on the subject. Finally, we show that albeit seemingly monolithic at first, the French system can also accommodate diversity to a certain extent, through looking at two particular contexts

Quantitative Skills and Reasoning (Armstrong)

This Grants Collection for Quantitative Skills and Reasoning was created under a Round Five ALG Textbook Transformation Grant. Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Reporthttps://oer.galileo.usg.edu/mathematics-collections/1021/thumbnail.jp

Sociolinguistique et éducation. Une approche ethnographique

Les travaux présentés dans cette Habilitation à Diriger des Recherches s’inscrivent dans le champ d’une sociolinguistique d’inspiration ethnographique dans le domaine de l’éducation. Ce positionnement en sciences du langage procède d’un cheminement personnel, conceptuel et méthodologique dont le mémoire de synthèse rend compte en s’appuyant sur des recherches individuelles et collectives qui s’échelonnent sur une dizaine d’années. Organisé selon trois axes thématiques, ce volume dresse un bil..

Evaluation of the Chlorophyll/Fluorescence Sensor of the YSI Multiprobe: Comparison to an Acetone Extraction Procedure

The purpose of this study was to examine the suitability of the YSI model 6600 Environmental Monitoring System (multiprobe) for long term deployment at a site in Lewisville Lake, Texas. Specifically, agreement between a laboratory extraction procedure and the multiprobe chlorophyll/fluorescence readings was examined. Preliminary studies involved determining the best method for disrupting algal cells prior to analysis and examining the precision and linearity of the acetone extraction procedure. Cell disruption by mortar and pestle grinding was preferable to bath sonication. Comparison of the chlorophyll/fluorescence readings from the multiprobe and the extraction procedure indicated that they were significantly correlated but temperature dependent

Le langage aux frontières du travail et de l’école. Une ethnographie des ateliers des lycées professionnels français

Les lycées professionnels français constituent, pour l’étude du langage et de la formation, un terrain aux frontières des champs du travail et de l’école. Dispositif emblématique de la position intermédiaire de ces lycées, l’« atelier d’école » est l’espace dans lequel se déroule l’enseignement pratique du métier. Les différentes contributions des réalités langagières aux apprentissages et à la socialisation des élèves y sont encore peu étudiées et mal connues. Afin de combler ce manque, nous avons entrepris la réalisation d’une série d’études de cas. Celles-ci constitueront à terme un « répertoire de configurations » fondé sur l’analyse d’un éventail de situations, d’évènements singuliers et de pratiques langagières en ateliers d’école. L’objectif de cet article est d’esquisser les motifs et les contours d’un tel répertoire

Purification and Studies of Methylglyoxal Reductase from Sheep Liver

The objectives of these investigations were (1) the purification of MG reductase from sheep liver and (2) studies of some of its characteristics. MG reductase was purified 40 fold and showed a single band on SDS-PAGE. Molecular weight estimations with SDS-PAGE showed a molecular weight of 44,000; although gel filtration with Sephadex G-150 gave a molecular weight of 87,000 indicating that the enzyme might be a dimer. The Km for MG is 1.42 mM and for NADH it is 0.04 mM. The pH optimum for the purified enzyme is pH 7.0. Isoelectric focusing experiments showed a pI of 9.3. In vivo experiments involving rats treated with 3,3',5-triiodothyronine (T_3) and 6-n-propyl-2-thiouracil (PTU) indicated that MG reductase was depressed by T_3 and elevated by PTU

An Abbreviated NAGPRA Inventory of the North Carolina Archaeological Collection

The Research Laboratories of Archaeology's inventory of human skeletal remains and associated and unassociated funerary objects from Native American sites in the North Carolina Archaeological Collection at the University of North Carolina at Chapel Hill

Epidemiological Agent-Based Modelling Software (Epiabm)

Epiabm is a fully tested, open-source software package for epidemiological agent-based modelling, re-implementing the well-known CovidSim model from the MRC Centre for Global Infectious Disease Analysis at Imperial College London. It has been developed as part of the first-year training programme in the EPSRC SABS:R3 Centre for Doctoral Training at the University of Oxford. The model builds an age-stratified, spatially heterogeneous population and offers a modular approach to configure and run epidemic scenarios, allowing for a broad scope of investigative and comparative studies. Two simulation backends are provided: a pedagogical Python backend (with full functionality) and a high performance C++ backend for use with larger population simulations. Both are highly modular, with comprehensive testing and documentation for ease of understanding and extensibility. Epiabm is publicly available through GitHub at https://github.com/SABS-R3-Epidemiology/epiabm.Comment: Submitted to Journal of Open Research Softwar

a4-Containing GABA _A Receptors on DRD2 Neurons of the Nucleus Accumbens Mediate Instrumental Responding for Conditioned Reinforcers and Its Potentiation by Cocaine

Extrasynaptic GABA A receptors (GABA ARs) composed of a4, b, and d subunits mediate GABAergic tonic inhibition and are potential molecular targets in the modulation of behavioral responses to natural and drug rewards. These GABA ARs are highly expressed within the nucleus accumbens (NAc), where they influence the excitability of the medium spiny neurons. Here, we explore their role in modulating behavioral responses to food-conditioned cues and the behavior-potentiating effects of cocaine. a4-Subunit constitutive knock-out mice (a4 /) showed higher rates of instrumental responding for reward-paired stimuli in a test of conditioned reinforcement (CRf). A similar effect was seen fol-lowing viral knockdown of GABA AR a4 subunits within the NAc. Local infusion of the a4b d-GABA AR-preferring agonist THIP (4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol; Gaboxadol) into the NAc had no effect on responding when given alone but reduced cocaine potentiation of responding for conditioned reinforcers in wild-type, but not a4 / mice. Finally, specific deletion of a4-subunits from dopamine D2, but not D1, receptor-expressing neurons (DRD2 and DRD1 neurons), mimicked the phenotype of the constitutive knockout, potentiating CRf responding, and blocking intra-accumbal THIP attenuation of cocaine-potentiated CRf responding. These data demonstrate that a4-GABA AR-mediated inhibition of DRD2 neurons reduces instrumental responding for a conditioned reinforcer and its po-tentiation by cocaine and emphasize the importance of GABAergic signaling within the NAc in mediating the effects of cocaine.</p

HOXA1 binds RBCK1/HOIL-1 and TRAF2 and modulates the TNF/NF-κB pathway in a transcription-independent manner

HOX proteins define a family of key transcription factors regulating animal embryogenesis. HOX genes have also been linked to oncogenesis and HOXA1 has been described to be active in several cancers, including breast cancer. Through a proteome-wide interaction screening, we previously identified the TNFR-associated proteins RBCK1/HOIL-1 and TRAF2 as HOXA1 interactors suggesting that HOXA1 is functionally linked to the TNF/NF-κB signaling pathway. Here, we reveal a strong positive correlation between expression of HOXA1 and of members of the TNF/NF-κB pathway in breast tumor datasets. Functionally, we demonstrate that HOXA1 can activate NF-κB and operates upstream of the NF-κB inhibitor IκB. Consistently, we next demonstrate that the HOXA1-mediated activation of NF-κB is non-transcriptional and that RBCK1 and TRAF2 influences on NF-κB are epistatic to HOXA1. We also identify an 11 Histidine repeat and the homeodomain of HOXA1 to be required both for RBCK1 and TRAF2 interaction and NF-κB stimulation. Finally, we highlight that activation of NF-κB is crucial for HOXA1 oncogenic activity