Satisfaction degree of elderly fully edentulous patients after insertion of a new fixed or removable full denture An integrative systematic review

Introdução: Progressivamente ao longo dos anos, o número de idosos tem vindo a aumentar. Nesta faixa etária, os problemas dentários tendem a ser mais persistentes e severos, por terem sido muitas das vezes negligenciamos em prol de outras urgências sanitárias. Neste sentido, é crucial compreender como melhorar a atual qualidade de vida e determinar se os problemas e tratamentos dentários têm um impacto sobre ela. Objectivo: Avaliar o grau de satisfação de pacientes idosos totalmente edêntulos após a inserção de uma nova prótese total fixa ou removível. Materiais e métodos: Foi realizada uma pesquisa bibliográfica nas bases de dados Pubmed, Scielo, Cochrane, Science direct e EBSCO, utilizando a seguinte combinação de termos de pesquisa "Quality of life" OR "Satisfaction" AND "Elderly" OR "Aged"AND "Complete denture" AND "Edentulous". Resultados: Foram seleccionados um total de 17 artigos publicados entre os anos 2012 e 2023, por cumprirem os critérios previamente definidos. Discussão: Perceber os factores psicossociais que afectam a eficácia dos cuidados terapêuticos e a qualidade de vida dos pacientes edêntulos é crucial para melhorar o seu bem-estar. Estudos demonstraram que a satisfação do paciente com as novas dentaduras completas está significativamente associada a uma melhor qualidade de vida relacionada com a saúde oral, enquanto as próteses sobre implantes podem proporcionar maior estabilidade, força de mordida e satisfação, levando a uma melhor qualidade de vida global. Conclusão: A qualidade de vida da população idosa total edêntula poderia ser melhorada através da realização de novas próteses totais.Introduction: Progressively over the years, the number of elderly people has been increasing. In this age group, dental issues tend to be more persistent and severe, because they have often been neglected in favour of other health emergencies. In this sense, it is crucial to understand how to improve the current elderly people quality of life and determine whether dental issues and treatments have an impact on it. Aim: Evaluate the satisfaction degree of elderly fully edentulous patients after insertion of a new fixed or removable full denture. Materials and methods: A literature search was conducted in the Pubmed, Scielo, Cochrane, Science direct and EBSCO databases, using the following combination of search terms "Quality of life" OR "Satisfaction" AND "Elderly" OR "Aged "AND "Complete denture" AND "Edentulous". Results: Were selected a total of 17 articles, published between the years 2012 and 2023, in order to meet the previously defined criteria. Discussion: Understanding the psychosocial factors that impact the effectiveness of therapeutic care and quality of life for edentulous patients is crucial for improving their well-being. Studies have shown that patient satisfaction with new complete dentures is significantly associated with improved oral health-related quality of life, while implant overdentures can provide enhanced stability, bite force and satisfaction, leading to improved overall quality of life. Conclusion: The quality of life of the total edentulous elderly population could be improved through the realisation of new total prostheses

Epstein–Barr Virus-Associated T- and NK-Cell Lymphoproliferative Diseases: A Review of Clinical and Pathological Features

Epstein–Barr virus (EBV) is a ubiquitous virus detected in up to 95% of the general population. Most people are asymptomatic, while some may develop a wide range of EBV-associated lymphoproliferative disorders (LPD). Among them, EBV-positive T/NK LPD are uncommon diseases defined by the proliferation of T- or NK-cells infected by EBV. The 2017 World Health Organization (WHO) classification recognizes the following entities characterized by different outcomes: chronic active EBV infection of T- or NK-cell types (cutaneous and systemic forms), systemic EBV-positive T-cell lymphoma of childhood, EBV-positive aggressive NK-cell leukemia, extra nodal NK/T-cell lymphoma nasal type, and the new provisional entity known as primary EBV-positive nodal T/NK-cell lymphoma. In addition, EBV associated-hemophagocytic lymphohistiocytosis is part of EBV-positive T/NK LPD, but has not been included in the WHO classification due to its reactive nature. Despite novel insights from high-throughput molecular studies, EBV-positive NK/T-cell LPD diagnoses remain challenging, especially because of their rarity and overlap. Until now, an accurate EBV-positive NK/T LPD diagnosis has been based on its clinical presentation and course correlated with its histological features. This review aims to summarize clinical, pathological and molecular features of EBV-positive T/NK LPD subtypes and to provide an overview of new understandings regarding these rare disorders

Histological Subtypes Drive Distinct Prognostic Immune Signatures in Classical Hodgkin Lymphoma

International audienceSimple Summary Classical Hodgkin lymphoma (cHL) is a highly curable disease, with about 80% of patients cured using standard first-line chemotherapy. However, outcomes for relapsed/refractory patients remain unfavorable and there is a critical lack of predictive biomarkers for early identification of these patients who may benefit from new therapeutic strategies. Here we evaluated the dynamic expression of 586 immune-related genes in a cohort of 42 cHL patients using NanoString technology. We identified a 19-gene immune signature predictive of relapse at the time of diagnosis, which was found to be strongly dependent on histological subtype. Moreover, comparative analyses between paired diagnostic/relapsed biopsies of nodular sclerosis cHL showed 118 differentially expressed genes, highlighting an immune contexture shift at relapse not found in mixed-cellularity cases. Overall, these results strongly suggest that the predictive value of immune signature in cHL is influenced by histological subtype, a criterion that should be considered when assessing new immunotherapy strategies. Despite the success of standard front-line chemotherapy, 20% of classical Hodgkin lymphoma (cHL) patients still relapse or have refractory disease (r/r), and a subset of them die due to disease progression. There is a critical lack of predictive factors for early identification of those r/r patients who may benefit from new therapeutic strategies. This study aimed to evaluate the dynamic expression of 586 immune-related genes in a cohort of 42 cHL patients including 30 r/r cHL after first-line chemotherapy. Gene expression profiling (GEP) using NanoString technology identified a 19-gene immune signature at diagnosis predictive of cHL relapse, but dependent on histological subtypes. Genes related to tumor survival were found upregulated while genes related to B-lineage were downregulated at diagnosis in r/r nodular sclerosis cHL. In contrast to the mixed-cellularity subtype, comparative GEP analyses between paired diagnosis/relapse biopsies of nodular sclerosis cHL showed 118 differentially expressed genes, supporting an immune contexture switch at relapse with upregulation of immunosuppressive cytokines, such as LGALS1 and TGFB1, and downregulation of the T-cell co-stimulatory receptor ICOS. These results indicate that the predictive value of immune signature in cHL is strongly influenced by histological subtype which should be considered when assessing new immunotherapy target strategies