23,929 research outputs found
Hybrid biomedical intelligent systems
"Copyright © 2012 Maysam Abbod et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited."The purpose of this special issue is to promote research and developments of the best work in the field of hybrid intelligent systems for biomedical applications
Understanding the role of chromatin remodeling in the regulation of circadian transcription in Drosophila.
Circadian clocks enable organisms to anticipate daily changes in the environment and coordinate temporal rhythms in physiology and behavior with the 24-h day-night cycle. The robust cycling of circadian gene expression is critical for proper timekeeping, and is regulated by transcription factor binding, RNA polymerase II (RNAPII) recruitment and elongation, and post-transcriptional mechanisms. Recently, it has become clear that dynamic alterations in chromatin landscape at the level of histone posttranslational modification and nucleosome density facilitate rhythms in transcription factor recruitment and RNAPII activity, and are essential for progression through activating and repressive phases of circadian transcription. Here, we discuss the characterization of the BRAHMA (BRM) chromatin-remodeling protein in Drosophila in the context of circadian clock regulation. By dissecting its catalytic vs. non-catalytic activities, we propose a model in which the non-catalytic activity of BRM functions to recruit repressive factors to limit the transcriptional output of CLOCK (CLK) during the active phase of circadian transcription, while the primary function of the ATP-dependent catalytic activity is to tune and prevent over-recruitment of negative regulators by increasing nucleosome density. Finally, we divulge ongoing efforts and investigative directions toward a deeper mechanistic understanding of transcriptional regulation of circadian gene expression at the chromatin level
Ion collection by oblique surfaces of an object in a transversely-flowing strongly-magnetized plasma
The equations governing a collisionless obliquely-flowing plasma around an
ion-absorbing object in a strong magnetic field are shown to have an exact
analytic solution even for arbitrary (two-dimensional) object-shape, when
temperature is uniform, and diffusive transport can be ignored. The solution
has an extremely simple geometric embodiment. It shows that the ion collection
flux density to a convex body's surface depends only upon the orientation of
the surface, and provides the theoretical justification and calibration of
oblique `Mach-probes'. The exponential form of this exact solution helps
explain the approximate fit of this function to previous numerical solutions.Comment: Four pages, 2 figures. Submitted to Phys. Rev. Letter
Phase II of the ASCE Benchmark Study on SHM
The task group on structural health monitoring of the Dynamic Committee of ASCE was formed in
1999 at the 12
th
Engineering Mechanics Conference. The task group has designed a number of analytical
studies on a benchmark structure and there are plans to follow these with an experimental program. The
first phase of the analytical studies was completed in 2001. The second phase, initiated in the summer of
2001, was formulated in the light of the experience gained on phase I and focuses on increasing realism in
the simulation of the discrepancies between the actual structure and the mathematical model used in the
analysis. This paper describes the rational that lead the SHM task group to the definition of phase II and
presents the details of the cases that are being considered
Finite Symmetry of Leptonic Mass Matrices
We search for possible symmetries present in the leptonic mixing data from
SU(3) subgroups of order up to 511. Theoretical results based on symmetry are
compared with global fits of experimental data in a chi-squared analysis,
yielding the following results. There is no longer a group that can produce all
the mixing data without a free parameter, but a number of them can accommodate
the first or the second column of the mixing matrix. The only group that fits
the third column is . It predicts and
, in good agreement with experimental results.Comment: Version to appear in Physical Review
Implementing Unitarity in Perturbation Theory
Unitarity cannot be perserved order by order in ordinary perturbation theory
because the constraint UU^\dagger=\1 is nonlinear. However, the corresponding
constraint for , being , is linear so it can be
maintained in every order in a perturbative expansion of . The perturbative
expansion of may be considered as a non-abelian generalization of the
linked-cluster expansion in probability theory and in statistical mechanics,
and possesses similar advantages resulting from separating the short-range
correlations from long-range effects. This point is illustrated in two QCD
examples, in which delicate cancellations encountered in summing Feynman
diagrams of are avoided when they are calculated via the perturbative expansion
of . Applications to other problems are briefly discussed.Comment: to appear in Phys. Rev.
Direct measurement of penetration length in ultra-thin and/or mesoscopic superconducting structures
We describe a method for direct measurement of the magnetic penetration
length in thin (10 - 100 nm) superconducting structures having overall
dimensions in the range 1 to 100 micrometers. The method is applicable for
broadband magnetic fields from dc to MHz frequencies.Comment: Accepted by Journal of Applied P:hysics (Jun 2006).5 pages, 5 figure
Schubert Polynomials for the affine Grassmannian of the symplectic group
We study the Schubert calculus of the affine Grassmannian Gr of the
symplectic group. The integral homology and cohomology rings of Gr are
identified with dual Hopf algebras of symmetric functions, defined in terms of
Schur's P and Q-functions. An explicit combinatorial description is obtained
for the Schubert basis of the cohomology of Gr, and this is extended to a
definition of the affine type C Stanley symmetric functions. A homology Pieri
rule is also given for the product of a special Schubert class with an
arbitrary one.Comment: 45 page
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