2.5 D Cavity Balancing

Cavity balancing is the process of altering the flow front within a cavity through thickness and design changes such that the desired fill pattern is achieved. The 2 dimensional (2D) cavity-balancing algorithm, developed by Lam and Seow [1] can only handle 2D geometry. This represents a major drawback as most, if not all of the practical injected parts are not 2D parts. To overcome this difficulty, the present investigation has developed a 2.5 dimensional (2.5D) cavity balancing optimization routine implemented within a 2.5 D finite elements domain. The aim of the automated cavity balancing routine is to reduce product development time and to improve product quality. This will lower the level of prerequisite expert knowledge necessary for successful mold and part design. The automated cavity balancing routine has been developed using the concept of flow paths. The hill-climbing algorithm of Lam and Seow is utilized but modified for the generation of flow paths for 2.5D parts. The algorithm has been implemented in a computer program running as an external loop to the MOLDFLOW software. Case studies are provided to demonstrate the efficiency of this routine.Singapore-MIT Alliance (SMA

An Analytical Solution on Convective and Diffusive Transport of Analyte in Laminar Flow of Microfluidic Slit

Microfluidic devices could find applications in many areas, such as BioMEMs, miniature fuel cells and microfluidic cooling of electronic circuitry. One of the important considerations of microfluidic device in analytical and bioanalytical chemistry is the dispersion of solute. In this study, we have developed an analytical solution, which considers the axial dispersion of a solute along the flow direction, to simulate convection and diffusion transport in a pressure driven creeping flow for a rectangular shape slit. During flow, the balance of competing effects of diffusion (especially cross-section diffusion) and convective diffusion in the flow direction are investigated.Singapore-MIT Alliance (SMA

Electroosmotic Flow in Microchannel with Black Silicon Nanostructures

Although electroosmotic flow (EOF) has been applied to drive fluid flow in microfluidic chips, some of the phenomena associated with it can adversely affect the performance of certain applications such as electrophoresis and ion preconcentration. To minimize the undesirable effects, EOF can be suppressed by polymer coatings or introduction of nanostructures. In this work, we presented a novel technique that employs the Dry Etching, Electroplating and Molding (DEEMO) process along with reactive ion etching (RIE), to fabricate microchannel with black silicon nanostructures (prolate hemispheroid-like structures). The effect of black silicon nanostructures on EOF was examined experimentally by current monitoring method, and numerically by finite element simulations. The experimental results showed that the EOF velocity was reduced by 13 ± 7%, which is reasonably close to the simulation results that predict a reduction of approximately 8%. EOF reduction is caused by the distortion of local electric field at the nanostructured surface. Numerical simulations show that the EOF velocity decreases with increasing nanostructure height or decreasing diameter. This reveals the potential of tuning the etching process parameters to generate nanostructures for better EOF suppression. The outcome of this investigation enhances the fundamental understanding of EOF behavior, with implications on the precise EOF control in devices utilizing nanostructured surfaces for chemical and biological analyses

The Transverse Particle Migration of Highly Filled Polymer Fluid Flow in a Pipe

Shear-induced particle migration was investigated by using a continuum diffusive -flux model for the creep flow of nickel powder filled polymers, which are viscous with shear-thinning characteristic. The model, together with flow equations, was employed for solving the non-Newtonian flow patterns and non-uniform particle concentration distribution of mono-modal suspensions in a pressure-driven tube flow. Particle volume fraction and velocity fields for the non-homogenous shear flow field were predicted for 40% particle volume fraction. The model captures the trends found in experimental investigations.Singapore-MIT Alliance (SMA

Review of bio-particle manipulation using dielectrophoresis

During the last decade, large and costly instruments are being replaced by system based on microfluidic devices. Microfluidic devices hold the promise of combining a small analytical laboratory onto a chip-sized substrate to identify, immobilize, separate, and purify cells, bio-molecules, toxins, and other chemical and biological materials. Compared to conventional instruments, microfluidic devices would perform these tasks faster with higher sensitivity and efficiency, and greater affordability. Dielectrophoresis is one of the enabling technologies for these devices. It exploits the differences in particle dielectric properties to allow manipulation and characterization of particles suspended in a fluidic medium. Particles can be trapped or moved between regions of high or low electric fields due to the polarization effects in non-uniform electric fields. By varying the applied electric field frequency, the magnitude and direction of the dielectrophoretic force on the particle can be controlled. Dielectrophoresis has been successfully demonstrated in the separation, transportation, trapping, and sorting of various biological particles.Singapore-MIT Alliance (SMA

Particle Migration of Quasi-Steady Flow in Concentrated Suspension for Powder Injection Molding

A hybrid FEM/FDM algorithm for particle migration of quasi-steady flow in concentrated suspension materials is proposed in this study. This hybrid FEM/FDM algorithm in which the planar variables, such as pressure field, are described in terms of finite element method, and gapwise variables of temperature, density concentration and time derivatives are expressed by finite difference method. The particle concentration inhomogeneities can be predicted, which is ignored by the existing injection molding simulation packages. Simulation results indicated that powder concentration variation could be significant in practical processing in PIM.Singapore-MIT Alliance (SMA

Particle Transportation Using Programmable Electrode Arrays

This study presents a technique to manipulate particles in microchannels using arrays of individually excitable electrodes. These electrodes were energized sequentially to form a non-uniform electric field that moved along the microchannel. The non-uniform electric field caused dielectrophoresis to make polarized particles move. This technique was demonstrated using viable yeast cells in a suspending medium with different conductivities. The viable yeast cells experienced positive dielectrophoresis and negative dielectrophoresis in medium conductivity of 21.5 μS/cm and 966 μS/cm respectively. The experimental results indicate that the cells can be transported in either condition using the proposed technique.Singapore-MIT Alliance (SMA

Numerical Simulation of Electroosmotic Flow with Step Change in Zeta Potential

Electroosmotic flow is a convenient mechanism for transporting polar fluid in a microfluidic device. The flow is generated through the application of an external electric field that acts on the free charges that exists in a thin Debye layer at the channel walls. The charge on the wall is due to the chemistry of the solid-fluid interface, and it can vary along the channel, e.g. due to modification of the wall. This investigation focuses on the simulation of the electroosmotic flow (EOF) profile in a cylindrical microchannel with step change in zeta potential. The modified Navier-Stoke equation governing the velocity field and a non-linear two-dimensional Poisson-Boltzmann equation governing the electrical double-layer (EDL) field distribution are solved numerically using finite control-volume method. Continuities of flow rate and electric current are enforced resulting in a non-uniform electrical field and pressure gradient distribution along the channel. The resulting parabolic velocity distribution at the junction of the step change in zeta potential, which is more typical of a pressure-driven velocity flow profile, is obtained.Singapore-MIT Alliance (SMA

Generation of Dielectrophoretic Force under Uniform Electric Field

Effective dipole moment method has been widely accepted as the de facto technique in predicting the dielectrophoretic force due to the non-uniform electric field. In this method, a finite-particle is modeled as an equivalent point-dipole that would induce a same electric field under the external electric field. This approach is only valid when the particle size is significantly smaller than the characteristic length of interest. This assumption is often violated in a microfluidic device, where the thickness or width of the microchannel can be as small as the particle. It is shown in this numerical study that when the dimensions of the particle were in the same order of magnitude as the characteristic length of the device, dielectrophoretic force can be induced even in a uniform electric field. This force arises due to the disturbance of the particle and the bounding wall.Singapore-MIT Alliance (SMA