Large Mixing Induced by the Strong Coupling with a Single Bulk Neutrinos

Neutrino is a good probe of extra dimensions. Large mixing and the apparent lack of very complicated oscillation patterns may be an indication of large couplings between the brane and a single bulk neutrino. A simple and realistic five-dimensional model of this kind is discussed. It requires a sterile in addition to three active neutrinos on the brane, all coupled strongly to one common bulk neutrino, but not directly among themselves. Mindful that sterile neutrinos are disfavored in the atmospheric and solar data, we demand induced mixing to occur among the active neutrinos, but not between the active and the sterile. The size $R$ of the extra dimension is arbitrary in this model, otherwise it contains six parameters which can be used to fit the three neutrino masses and the three mixing angles. However, in the model those six parameters must be suitably ordered, so a successful fit is not guaranteed. It turns out that not only the data can be fitted, but as a result of the ordering, a natural connection between the smallness of the reactor angle $\theta_{13}$ and the smallness of the mass-gap ratio $\Delta M^2_{solar}/\Delta M^2_{atmospheric}$ can be derived.Comment: Misprints above eq. (22) corrected. To appear in PR

Tri-Bimaximal Mixing from Twisted Friedberg-Lee Symmetry

We investigate the Friedberg-Lee (FL) symmetry and its promotion to include the $\mu - \tau$ symmetry, and call that the twisted FL symmetry.Based on the twisted FL symmetry, two possible schemes are presented toward the realistic neutrino mass spectrum and the tri-bimaximal mixing.In the first scheme, we suggest the semi-uniform translation of the FL symmetry.The second one is based on the $S_3$ permutation family symmetry.The breaking terms, which are twisted FL symmetric, are introduced.Some viable models in each scheme are also presented.Comment: 14 pages, no figure. v2: 16 pages, modified some sentences, appendix added, references added. v3: 14 pages, composition simplified, accepted version in EPJ

Interaction of Akt-Phosphorylated Ataxin-1 with 14-3-3 Mediates Neurodegeneration in Spinocerebellar Ataxia Type 1

AbstractSpinocerebellar ataxia type 1 (SCA1) is one of several neurological disorders caused by a CAG repeat expansion. In SCA1, this expansion produces an abnormally long polyglutamine tract in the protein ataxin-1. Mutant polyglutamine proteins accumulate in neurons, inducing neurodegeneration, but the mechanism underlying this accumulation has been unclear. We have discovered that the 14-3-3 protein, a multifunctional regulatory molecule, mediates the neurotoxicity of ataxin-1 by binding to and stabilizing ataxin-1, thereby slowing its normal degradation. The association of ataxin-1 with 14-3-3 is regulated by Akt phosphorylation, and in a Drosophila model of SCA1, both 14-3-3 and Akt modulate neurodegeneration. Our finding that phosphatidylinositol 3-kinase/Akt signaling and 14-3-3 cooperate to modulate the neurotoxicity of ataxin-1 provides insight into SCA1 pathogenesis and identifies potential targets for therapeutic intervention

Turner syndrome: skin, liver, eyes, dental and ENT evaluation should be improved.

Turner syndrome association with multi-organ system comorbidities highlights the need for effective implementation of follow-up guidelines. We aimed to assess the adequacy of care with international guidelines published in 2007 and 2017 and to describe the phenotype of patients. In this multicenter retrospective descriptive cohort study, we collected growth and pubertal parameters, associated comorbidities, treatment, and karyotype in patients diagnosed at age <18 years between 1993 and 2022. We assessed age-appropriate recommendation follow-up (children, adolescents and adults) according to the 2007 guidelines if the last visit was before 2017 (18 recommendations) and the 2017 guidelines if the last visit was after 2017 (19 recommendations). We included 68 patients followed at Lausanne University Hospital (n=64) and at Neuchatel Regional Hospital (RHNe) (n=4). 2.9% of patients underwent all recommended investigations.Overall, 68.9 ± 22.5% and 78.5 ± 20.6% of the recommendations were followed, before and after 2017 respectively. High implementation rates were found for height, weight and BMI (100%), cardiac (80 to 100%) and renal (90 to 100%) imaging. Low implementation rates were found for Ear, Nose and Throat (ENT) (56.5%), skin (38.5%), dental (23.1%), ophthalmological (10%) and cholestasis (0 to 29%) assessments, depending on age and time of visit. In adults (n=33), the mean proportion of followed recommendations was lower before than after 2017: 63.5 ± 25.8% vs. 78.7 ± 23.4%, p=0.039. Growth parameters, cardiac and renal imaging are well followed. However, efforts should be made for dental, ENT, ophthalmological, skin and cholestasis assessments. Adequacy of follow-up improved with the quality of transition to adult care

Renormalization Group Running of Lepton Mixing Parameters in See-Saw Models with S4S_4 Flavor Symmetry

We study the renormalization group running of the tri-bimaximal mixing predicted by the two typical $S_4$ flavor models at leading order. Although the textures of the mass matrices are completely different, the evolution of neutrino mass and mixing parameters is found to display approximately the same pattern. For both normal hierarchy and inverted hierarchy spectrum, the quantum corrections to both atmospheric and reactor neutrino mixing angles are so small that they can be neglected. The evolution of the solar mixing angle $\theta_{12}$ depends on $\tan\beta$ and neutrino mass spectrum, the deviation from its tri-bimaximal value could be large. Taking into account the renormalization group running effect, the neutrino spectrum is constrained by experimental data on $\theta_{12}$ in addition to the self-consistency conditions of the models, and the inverted hierarchy spectrum is disfavored for large $\tan\beta$. The evolution of light-neutrino masses is approximately described by a common scaling factor.Comment: 23 pages, 6figure

Nuclear effects in the Drell-Yan process at very high energies

We study Drell-Yan (DY) dilepton production in proton(deuterium)-nucleus and in nucleus-nucleus collisions within the light-cone color dipole formalism. This approach is especially suitable for predicting nuclear effects in the DY cross section for heavy ion collisions, as it provides the impact parameter dependence of nuclear shadowing and transverse momentum broadening, quantities that are not available from the standard parton model. For p(D)+A collisions we calculate nuclear shadowing and investigate nuclear modification of the DY transverse momentum distribution at RHIC and LHC for kinematics corresponding to coherence length much longer than the nuclear size. Calculations are performed separately for transversely and longitudinally polarized DY photons, and predictions are presented for the dilepton angular distribution. Furthermore, we calculate nuclear broadening of the mean transverse momentum squared of DY dileptons as function of the nuclear mass number and energy. We also predict nuclear effects for the cross section of the DY process in heavy ion collisions. We found a substantial nuclear shadowing for valence quarks, stronger than for the sea.Comment: 46 pages, 18 figures, title changed and some discussion added, accepted for publication in PR

Constraints on Large Extra Dimensions with Bulk Neutrinos

We consider right-handed neutrinos propagating in $\delta$ (large) extra dimensions, whose only coupling to Standard Model fields is the Yukawa coupling to the left-handed neutrino and the Higgs boson. These theories are attractive as they can explain the smallness of the neutrino mass, as has already been shown. We show that if $\delta$ is bigger than two, there are strong constraints on the radius of the extra dimensions, resulting from the experimental limit on the probability of an active state to mix into the large number of sterile Kaluza-Klein states of the bulk neutrino. We also calculate the bounds on the radius resulting from requiring that perturbative unitarity be valid in the theory, in an imagined Higgs-Higgs scattering channel.Comment: 24 pages, 4 figures, revtex4. v2: Minor typos corrected, references adde

Dual Vortex Theory of Strongly Interacting Electrons: Non-Fermi Liquid to the (Hard) Core

As discovered in the quantum Hall effect, a very effective way for strongly-repulsive electrons to minimize their potential energy is to aquire non-zero relative angular momentum. We pursue this mechanism for interacting two-dimensional electrons in zero magnetic field, by employing a representation of the electrons as composite bosons interacting with a Chern-Simons gauge field. This enables us to construct a dual description in which the fundamental constituents are vortices in the auxiliary boson fields. The resulting formalism embraces a cornucopia of possible phases. Remarkably, superconductivity is a generic feature, while the Fermi liquid is not -- prompting us to conjecture that such a state may not be possible when the interactions are sufficiently strong. Many aspects of our earlier discussions of the nodal liquid and spin-charge separation find surprising incarnations in this new framework.Comment: Modified dicussion of the hard-core model, correcting several mistake

B-cell dysregulation in Crohn's disease is partially restored with infliximab therapy

Background: B-cell depletion can improve a variety of chronic inflammatory diseases, but does not appear beneficial for patients with Crohn's disease. Objective: To elucidate the involvement of B cells in Crohn's disease, we here performed an 'in depth' analysis of intestinal and blood B-cells in this chronic inflammatory disease. Methods: Patients with Crohn's disease were recruited to study B-cell infiltrates in intestinal biopsies (n = 5), serum immunoglobulin levels and the phenotype and molecular characteristics of blood B-cell subsets (n = 21). The effects of infliximab treatment were studied in 9 patients. Results: Granulomatous tissue showed infiltrates of B lymphocytes rather than Ig-secreting plasma cells. Circulating transitional B cells and CD21low B cells were elevated. IgM memory B cells were reduced and natural effector cells showed decreased replication histories and somatic hypermutation (SHM) levels. In contrast, IgG and IgA memory B cells were normally present and their Ig gene transcripts carried increased SHM levels. The numbers of transitional and natural effector cells were normal in patients who responded clinically well to infliximab. Conclusions: B cells in patients with Crohn's disease showed signs of chronic stimulation with localization to granulomatous tissue and increased molecular maturation of IgA and IgG. Therapy with TNFα-blockers restored the defect in IgM memory B-cell generation and normalized transitional B-cell levels, making these subsets candidate markers for treatment monitoring. Together, these results suggest a chronic, aberrant B-cell response in patients with Crohn's disease, which could be targeted with new therapeutics that specifically regulate B-cell function