3,949 research outputs found
The Prognostic Value of Eight Immunohistochemical Markers Expressed in the Tumor Microenvironment and on Hodgkin Reed-Sternberg Cells in Pediatric Patients With Classical Hodgkin Lymphoma
Immunohistochemical markers are associated with treatment outcome in adults with classical Hodgkin Lymphoma (cHL). Studies in children are scarce and inconsistent. We investigated in 67 children with cHL, whether the expression of CD15, CD30, PAX5, PD-1, PD-L1, CD68, CD163 and TARC at diagnosis is associated with disease free survival (DFS) and with interim remission status. Low CD15 and low TARC expression were associated with relapsed disease. Low expression of PD-L1 was associated with complete remission at interim PET-scan. Our data suggest a difference between pediatric and adult cHL. This underlines the importance of future research into specific prognostic factors in pediatric cHL, indispensable for improvement of treatment in this population
Case report:a fatal combination of hemophagocytic lymphohistiocytosis with extensive pulmonary microvascular damage in COVID-19 pneumonia
Flavor Symmetry L_mu - L_tau and quasi-degenerate Neutrinos
Current data implies three simple forms of the neutrino mass matrix, each
corresponding to the conservation of a non-standard lepton charge. While models
based on L_e and L_e - L_mu - L_tau are well-known, little attention has been
paid to L_mu - L_tau. A low energy mass matrix conserving L_mu - L_tau implies
quasi-degenerate light neutrinos. Moreover, it is mu-tau symmetric and
therefore (in contrast to L_e and L_e - L_mu - L_tau) automatically predicts
maximal atmospheric neutrino mixing and zero U_{e3}. A see-saw model based on
L_mu - L_tau is investigated and testable predictions for the neutrino mixing
observables are given. Renormalization group running below and in between the
see-saw scales is taken into account in our analysis, both numerically and
analytically.Comment: 15 pages, 2 figures. Prepared for 5th International Conference on
Nonaccelerator New Physics (NANP 05), Dubna, Russia, 20-25 Jun 200
Discrete symmetries and models of flavor mixing
Evidences of a discrete symmetry behind the pattern of lepton mixing are
analyzed. The program of "symmetry building" is outlined. Generic features and
problems of realization of this program in consistent gauge models are
formulated. The key issues include the flavor symmetry breaking, connection of
mixing and masses, {\it ad hoc} prescription of flavor charges, "missing"
representations, existence of new particles, possible accidental character of
the TBM mixing. Various ways are considered to extend the leptonic symmetries
to the quark sector and to reconcile them with Grand Unification. In this
connection the quark-lepton complementarity could be a viable alternative to
TBM. Observational consequences of the symmetries and future experimental tests
of their existence are discussed.Comment: 14 pages, 5 figures. Talk given at the Symposium "DISCRETE 2010", 6 -
11 December 2010, La Sapienza, Rome, Ital
Renormalization Group Running of Lepton Mixing Parameters in See-Saw Models with Flavor Symmetry
We study the renormalization group running of the tri-bimaximal mixing
predicted by the two typical flavor models at leading order. Although the
textures of the mass matrices are completely different, the evolution of
neutrino mass and mixing parameters is found to display approximately the same
pattern. For both normal hierarchy and inverted hierarchy spectrum, the quantum
corrections to both atmospheric and reactor neutrino mixing angles are so small
that they can be neglected. The evolution of the solar mixing angle
depends on and neutrino mass spectrum, the deviation
from its tri-bimaximal value could be large. Taking into account the
renormalization group running effect, the neutrino spectrum is constrained by
experimental data on in addition to the self-consistency
conditions of the models, and the inverted hierarchy spectrum is disfavored for
large . The evolution of light-neutrino masses is approximately
described by a common scaling factor.Comment: 23 pages, 6figure
Towards Minimal S4 Lepton Flavor Model
We study lepton flavor models with the flavor symmetry. We construct
simple models with smaller numbers of flavon fields and free parameters, such
that we have predictions among lepton masses and mixing angles. The model with
a triplet flavon is not realistic, but we can construct realistic models
with two triplet flavons, or one triplet and one doublet flavons.Comment: 18 pages, 4 figures, references are adde
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Mechanochromic, Structurally Colored, and Edible Hydrogels Prepared from Hydroxypropyl Cellulose and Gelatin
Abstract: Hydroxypropyl cellulose (HPC) is an edible, costâeffective and widely used derivative of cellulose. Under lyotropic conditions in water, HPC forms a photonic, liquid crystalline mesophase with an exceptional mechanochromic response. However, due to insufficient physical crossâlinking photonic HPC can flow freely as a viscous liquid, preventing the exploitation of this mechanochromic material in the absence of any external encapsulation or structural confinement. Here this challenge is addressed by mixing HPC and gelatin in water to form a selfâsupporting, viscoelastic, and edible supramolecular photonic hydrogel. It is demonstrated that the structural coloration, mechanochromism and nonâNewtonian shearâthinning behavior of the lyotropic HPC solutions can all be retained into the gel state. Moreover, the rigidity of the HPCâgel provides a 69% shorter mechanochromic relaxation time back to its initial color when compared to the liquid HPCâwater only system, broadening the dynamic color range of HPC by approximately 2.5Ă in response to a compressive pressure. Finally, the ability to formulate the HPCâgels in a scalable fashion from only water and âfoodâgradeâ constituents unlocks a wide range of potential applications, from responseâtunable mechanochromic materials and colorantâfree food decoration, to shortâterm sensors in, for example, biodegradable âsmart labelsâ for food packaging
Strong coupling, discrete symmetry and flavour
We show how two principles - strong coupling and discrete symmetry - can work
together to generate the flavour structure of the Standard Model. We propose
that in the UV the full theory has a discrete flavour symmetry, typically only
associated with tribimaximal mixing in the neutrino sector. Hierarchies in the
particle masses and mixing matrices then emerge from multiple strongly coupled
sectors that break this symmetry. This allows for a realistic flavour
structure, even in models built around an underlying grand unified theory. We
use two different techniques to understand the strongly coupled physics:
confinement in N=1 supersymmetry and the AdS/CFT correspondence. Both
approaches yield equivalent results and can be represented in a clear,
graphical way where the flavour symmetry is realised geometrically.Comment: 31 pages, 5 figures, updated references and figure
The Drosophila melanogaster PeptideAtlas facilitates the use of peptide data for improved fly proteomics and genome annotation
<p>Abstract</p> <p>Background</p> <p>Crucial foundations of any quantitative systems biology experiment are correct genome and proteome annotations. Protein databases compiled from high quality empirical protein identifications that are in turn based on correct gene models increase the correctness, sensitivity, and quantitative accuracy of systems biology genome-scale experiments.</p> <p>Results</p> <p>In this manuscript, we present the <it>Drosophila melanogaster </it>PeptideAtlas, a fly proteomics and genomics resource of unsurpassed depth. Based on peptide mass spectrometry data collected in our laboratory the portal <url>http://www.drosophila-peptideatlas.org</url> allows querying fly protein data observed with respect to gene model confirmation and splice site verification as well as for the identification of proteotypic peptides suited for targeted proteomics studies. Additionally, the database provides consensus mass spectra for observed peptides along with qualitative and quantitative information about the number of observations of a particular peptide and the sample(s) in which it was observed.</p> <p>Conclusion</p> <p>PeptideAtlas is an open access database for the <it>Drosophila </it>community that has several features and applications that support (1) reduction of the complexity inherently associated with performing targeted proteomic studies, (2) designing and accelerating shotgun proteomics experiments, (3) confirming or questioning gene models, and (4) adjusting gene models such that they are in line with observed <it>Drosophila </it>peptides. While the database consists of proteomic data it is not required that the user is a proteomics expert.</p
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