Higher education systems and industrial innovation: Final report of contract n° SOE 1-1054 - Project n° 1297 funded under the Targeted Socio-economic research (TSER) Programme-directorate general Science, Research and Development - Directorate F European Commission

Co-ordinator of project SESI : Eric Verdier - LEST (France). Partners : Alice Lam - CBS (United Kingdom) ; Christoph Buechtemann – CRIS (Germany) ; Helena Lopes - DINAMIA (Portugal) ; Lorenz Lassnigg - IHS (Austria) ; Jean-Michel Plassard - LIRHE (France)356 p.The objective of the research was to gather empirical evidence about efficient ways of organising the linkages and interfaces between higher education institutions (including research units) and private sector firms in order to spur industrial innovation. One of the project's principal aims was to combine two dimensions which are often considered separately : firstly, the construction of the competences and the professionalities of the actors involved in innovation, and, secondly, transfers of knowledge from higher education to firms and vice versa. Five European countries (Austria, France, Germany, Portugal, UK) were selected in order to provide, at least by way of an initial hypothesis, national systems that were sufficiently disparate from the point of view of the resources "offered" to companies, be it in terms of institutions, organisations or actors. It was essential to include the United States. Indeed, the relations between higher education and companies which have evolved in that country are undoubtedly an international point of reference Three sectors were chosen in each country as being representative of the new challenges emerging for the relationship between higher education and industry in key sectors where generic technologies are tending to develop, albeit in different ways. The investigations within more than 40 firms form the empirical basis of this project. The main results could be summarized as follows :1.The type of skills and competence profiles required of R&D workers are now more demanding in multiple dimensions, particularly in the combination of technical disciplinary expertise with a broad range of business, management and social skills. Emerging evidence suggests that firms are developing 'extended internal labour markets' (EILMs ) through closer links with key universities. The social networks embedded in such EILMs facilitate training and rapid transmission of evolving (uncodified) knowledge. 2. The sample of multinational firms we have selected enables us to take stock of the moves towards industrial rationalization taken by firms seeking to develop their technological globalization strategies by exploiting a diversity of cognitive resources. Preparation for the recruitment and integration of young graduates play crucial roles in the absorption of knowledge. 3. We found six coherent types of science industry relations that we describe precisely. These results further confirm the criticality of research agendas compatibility, favouring two different ways of collaborating associating an industrial partner and an academic one. 4. The analysis identifies four main types of intermediate actors : those actors who are the medium for an economic relationship between the firm and the HERS; the "gatekeepers", who work for a firm or a HERS ; the hybrid actors have been through the process of aligning the practices, rules and values of their "home" system (industry or academia) with those of their partner ; those who are involved in the trilateral network but are independent or on the road to being independent of the partners. 5. Labour-market entry of graduates is one of the factors which allows us to introduce all the signalling/human capital/network problematics and relate it to the emergence of an new form of labour market which combines the mechanisms of the internal and external markets. In spite of this diversity of practices, however, we maintain the hypothesis that it is possible to identify dominant forms of these relations which differ from one country to another. 6. Nevertheless the report insists on the increasing human capital mobility in high tech sectors and supply some evidence of an emerging European innovation systems. 7. Considering a US-Germany comparison, we infer that in IPR matters, German public research institutes – representative of the European continental situation - are facing a dilemma: they need to provide more pre-development type services for industry, involving stricter IPR claims from corporate partners and they also need to retain IPR in core areas of expertise in order to prevent a "bleeding out" and remain a partner for industry in the future.Finally the report provides different policy formulations and recommendations. We underline that for firms, the main objective is to resolve the problems posed by the transition from knowledge to competences. With an OLM of PhD level, the firms, especially very small ones, enable to have easier access to a suitably trained workforce. By promoting the circulation of knowledge, these markets help to reduce the previous conceptual gaps and to promote the creation of greater absorptive capacities at firms, as well as sustaining the spirit of mutual trust and reciprocity in which these networks were founded.At the national level, the lessons learned by public policy makers will be dealt with them in the generalfollowing order :- The United Kingdom, where the policies and regulations are typically market oriented is undergoing a process of specialization.- In France and Germany, where the relations between Science and Industry are facing fairly similar challenges, the scenario tends to alternated between radical change and a process of accommodation.- Austria and Portugal, which have rather different technological and industrial structures, but are both facing the special challenge of adapting the small scale national systems of innovation to the European Union and world-wide competition in general

Higher education systems and industrial innovation: Final report of contract n° SOE 1-1054 - Project n° 1297 funded under the Targeted Socio-economic research (TSER) Programme-directorate general Science, Research and Development - Directorate F European Commission

Co-ordinator of project SESI : Eric Verdier - LEST (France). Partners : Alice Lam - CBS (United Kingdom) ; Christoph Buechtemann – CRIS (Germany) ; Helena Lopes - DINAMIA (Portugal) ; Lorenz Lassnigg - IHS (Austria) ; Jean-Michel Plassard - LIRHE (France)356 p.The objective of the research was to gather empirical evidence about efficient ways of organising the linkages and interfaces between higher education institutions (including research units) and private sector firms in order to spur industrial innovation. One of the project's principal aims was to combine two dimensions which are often considered separately : firstly, the construction of the competences and the professionalities of the actors involved in innovation, and, secondly, transfers of knowledge from higher education to firms and vice versa. Five European countries (Austria, France, Germany, Portugal, UK) were selected in order to provide, at least by way of an initial hypothesis, national systems that were sufficiently disparate from the point of view of the resources "offered" to companies, be it in terms of institutions, organisations or actors. It was essential to include the United States. Indeed, the relations between higher education and companies which have evolved in that country are undoubtedly an international point of reference Three sectors were chosen in each country as being representative of the new challenges emerging for the relationship between higher education and industry in key sectors where generic technologies are tending to develop, albeit in different ways. The investigations within more than 40 firms form the empirical basis of this project. The main results could be summarized as follows :1.The type of skills and competence profiles required of R&D workers are now more demanding in multiple dimensions, particularly in the combination of technical disciplinary expertise with a broad range of business, management and social skills. Emerging evidence suggests that firms are developing 'extended internal labour markets' (EILMs ) through closer links with key universities. The social networks embedded in such EILMs facilitate training and rapid transmission of evolving (uncodified) knowledge. 2. The sample of multinational firms we have selected enables us to take stock of the moves towards industrial rationalization taken by firms seeking to develop their technological globalization strategies by exploiting a diversity of cognitive resources. Preparation for the recruitment and integration of young graduates play crucial roles in the absorption of knowledge. 3. We found six coherent types of science industry relations that we describe precisely. These results further confirm the criticality of research agendas compatibility, favouring two different ways of collaborating associating an industrial partner and an academic one. 4. The analysis identifies four main types of intermediate actors : those actors who are the medium for an economic relationship between the firm and the HERS; the "gatekeepers", who work for a firm or a HERS ; the hybrid actors have been through the process of aligning the practices, rules and values of their "home" system (industry or academia) with those of their partner ; those who are involved in the trilateral network but are independent or on the road to being independent of the partners. 5. Labour-market entry of graduates is one of the factors which allows us to introduce all the signalling/human capital/network problematics and relate it to the emergence of an new form of labour market which combines the mechanisms of the internal and external markets. In spite of this diversity of practices, however, we maintain the hypothesis that it is possible to identify dominant forms of these relations which differ from one country to another. 6. Nevertheless the report insists on the increasing human capital mobility in high tech sectors and supply some evidence of an emerging European innovation systems. 7. Considering a US-Germany comparison, we infer that in IPR matters, German public research institutes – representative of the European continental situation - are facing a dilemma: they need to provide more pre-development type services for industry, involving stricter IPR claims from corporate partners and they also need to retain IPR in core areas of expertise in order to prevent a "bleeding out" and remain a partner for industry in the future.Finally the report provides different policy formulations and recommendations. We underline that for firms, the main objective is to resolve the problems posed by the transition from knowledge to competences. With an OLM of PhD level, the firms, especially very small ones, enable to have easier access to a suitably trained workforce. By promoting the circulation of knowledge, these markets help to reduce the previous conceptual gaps and to promote the creation of greater absorptive capacities at firms, as well as sustaining the spirit of mutual trust and reciprocity in which these networks were founded.At the national level, the lessons learned by public policy makers will be dealt with them in the generalfollowing order :- The United Kingdom, where the policies and regulations are typically market oriented is undergoing a process of specialization.- In France and Germany, where the relations between Science and Industry are facing fairly similar challenges, the scenario tends to alternated between radical change and a process of accommodation.- Austria and Portugal, which have rather different technological and industrial structures, but are both facing the special challenge of adapting the small scale national systems of innovation to the European Union and world-wide competition in general

Higher education systems and industrial innovation : January 1998 to 31 May 2001

Co-ordinator of project SESI : Eric Verdier - LEST (France). Partners : Alice Lam - CBS (United Kingdom) ; Christoph Buechtemann – CRIS (Germany) ; Helena Lopes - DINAMIA (Portugal) ; Lorenz Lassnigg - IHS (Austria) ; Jean-Michel Plassard - LIRHE (France)132 p.The objective of the research was to gather empirical evidence about efficient ways of organising the linkages and interfaces between higher education institutions (including research units) and private sector firms in order to spur industrial innovation. One of the project's principal aims was to combine two dimensions which are often considered separately : firstly, the construction of the competences and the professionalities of the actors involved in innovation, and, secondly, transfers of knowledge from higher education to firms and vice versa. Five European countries (Austria, France, Germany, Portugal, UK) were selected in order to provide, at least by way of an initial hypothesis, national systems that were sufficiently disparate from the point of view of the resources "offered" to companies, be it in terms of institutions, organisations or actors. It was essential to include the United States. Indeed, the relations between higher education and companies which have evolved in that country are undoubtedly an international point of reference Three sectors were chosen in each country as being representative of the new challenges emerging for the relationship between higher education and industry in key sectors where generic technologies are tending to develop, albeit in different ways. The investigations within more than 40 firms form the empirical basis of this project. The main results could be summarized as follows :1.The type of skills and competence profiles required of R&D workers are now more demanding in multiple dimensions, particularly in the combination of technical disciplinary expertise with a broad range of business, management and social skills. Emerging evidence suggests that firms are developing 'extended internal labour markets' (EILMs ) through closer links with key universities. The social networks embedded in such EILMs facilitate training and rapid transmission of evolving (uncodified) knowledge. 2. The sample of multinational firms we have selected enables us to take stock of the moves towards industrial rationalization taken by firms seeking to develop their technological globalization strategies by exploiting a diversity of cognitive resources. Preparation for the recruitment and integration of young graduates play crucial roles in the absorption of knowledge. 3. We found six coherent types of science industry relations that we describe precisely. These results further confirm the criticality of research agendas compatibility, favouring two different ways of collaborating associating an industrial partner and an academic one. 4. The analysis identifies four main types of intermediate actors : those actors who are the medium for an economic relationship between the firm and the HERS; the "gatekeepers", who work for a firm or a HERS ; the hybrid actors have been through the process of aligning the practices, rules and values of their "home" system (industry or academia) with those of their partner ; those who are involved in the trilateral network but are independent or on the road to being independent of the partners. 5. Labour-market entry of graduates is one of the factors which allows us to introduce all the signalling/human capital/network problematics and relate it to the emergence of an new form of labour market which combines the mechanisms of the internal and external markets. In spite of this diversity of practices, however, we maintain the hypothesis that it is possible to identify dominant forms of these relations which differ from one country to another. 6. Nevertheless the report insists on the increasing human capital mobility in high tech sectors and supply some evidence of an emerging European innovation systems. 7. Considering a US-Germany comparison, we infer that in IPR matters, German public research institutes – representative of the European continental situation - are facing a dilemma: they need to provide more pre-development type services for industry, involving stricter IPR claims from corporate partners and they also need to retain IPR in core areas of expertise in order to prevent a "bleeding out" and remain a partner for industry in the future.Finally the report provides different policy formulations and recommendations. We underline that for firms, the main objective is to resolve the problems posed by the transition from knowledge to competences. With an OLM of PhD level, the firms, especially very small ones, enable to have easier access to a suitably trained workforce. By promoting the circulation of knowledge, these markets help to reduce the previous conceptual gaps and to promote the creation of greater absorptive capacities at firms, as well as sustaining the spirit of mutual trust and reciprocity in which these networks were founded.At the national level, the lessons learned by public policy makers will be dealt with them in the generalfollowing order :- The United Kingdom, where the policies and regulations are typically market oriented is undergoing a process of specialization.- In France and Germany, where the relations between Science and Industry are facing fairly similar challenges, the scenario tends to alternated between radical change and a process of accommodation.- Austria and Portugal, which have rather different technological and industrial structures, but are both facing the special challenge of adapting the small scale national systems of innovation to the European Union and world-wide competition in general

Transarterial RAdioembolization versus ChemoEmbolization for the treatment of hepatocellular carcinoma (TRACE) : study protocol for a randomized controlled trial

Background: Hepatocellular carcinoma is a primary malignant tumor of the liver that accounts for an important health problem worldwide. Only 10 to 15% of hepatocellular carcinoma patients are suitable candidates for treatment with curative intent, such as hepatic resection and liver transplantation. A majority of patients have locally advanced, liver restricted disease (Barcelona Clinic Liver Cancer (BCLC) staging system intermediate stage). Transarterial loco regional treatment modalities offer palliative treatment options for these patients; transarterial chemoembolization (TACE) is the current standard treatment. During TACE, a catheter is advanced into the branches of the hepatic artery supplying the tumor, and a combination of embolic material and chemotherapeutics is delivered through the catheter directly into the tumor. Yttrium-90 radioembolization (Y-90-RE) involves the transarterial administration of minimally embolic microspheres loaded with Yttrium-90, a beta-emitting isotope, delivering selective internal radiation to the tumor. Y-90-RE is increasingly used in clinical practice for treatment of intermediate stage hepatocellular carcinoma, but its efficacy has never been prospectively compared to that of the standard treatment (TACE). In this study, we describe the protocol of a multicenter randomized controlled trial aimed at comparing the effectiveness of TACE and Y-90-RE for treatment of patients with unresectable (BCLC intermediate stage) hepatocellular carcinoma. Methods/design: In this pragmatic randomized controlled trial, 140 patients with unresectable (BCLC intermediate stage) hepatocellular carcinoma, with Eastern Cooperative Oncology Group performance status 0 to 1 and Child-Pugh A to B will be randomly assigned to either Y-90-RE or TACE with drug eluting beads. Patients assigned to Y-90-RE will first receive a diagnostic angiography, followed by the actual transarterial treatment, which can be divided into two sessions in case of bilobar disease. Patients assigned to TACE will receive a maximum of three consecutive transarterial treatment sessions. Patients will undergo structural follow-up for a timeframe of two years post treatment. Post procedural magnetic resonance imaging (MRI) will be performed at one and three months post trial entry and at three-monthly intervals thereafter for two years to assess tumor response. Primary outcome will be time to progression. Secondary outcomes will be overall survival, tumor response according to the modified RECIST criteria, toxicities/adverse events, treatment related effect on total liver function, quality of life, treatment-related costs and cost-effectiveness

Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model

► Global levels of ubiquitinated proteins increased in the hippocampus of Tg2576 mice. ► No global changes in either SUMO-1 or SUMO-2/3 conjugation in any brain regions analysed. ► SUMO conjugating and deconjugating enzymes, UBC9 and SENP-1, unaltered in Tg2576 mice. ► Total levels of AMPA and kainate receptors were also unaffected in Tg2576 mice. ► Posttranslational modification by ubiquitin may play a role in Alzheimer's disease

Physical activity, respiratory physiotherapy practices, and nutrition among people with primary ciliary dyskinesia in Switzerland - a cross-sectional survey.

AIMS OF THE STUDY We know little about the level of physical activity, respiratory physiotherapy practices and nutritional status of people with primary ciliary dyskinesia (PCD), although these are important aspects of patients with chronic respiratory disease. We assessed physical activity, respiratory physiotherapy practices and nutritional status among people with primary ciliary dyskinesia in Switzerland, investigated how these vary by age and identified factors associated with regular physical activity. METHODS We sent a postal questionnaire survey to people with primary ciliary dyskinesia enrolled in the Swiss PCD registry (CH-PCD), based on the standardised FOLLOW-PCD patient questionnaire. We collected information about physical activity, physiotherapy, respiratory symptoms and nutritional status. We calculated the metabolic equivalent (MET) to better reflect the intensity of the reported physical activities. To assess nutritional status, we extracted information from CH-PCD and calculated participants' body mass index (BMI). RESULTS Of the 86 questionnaires we sent, 74 (86% response rate) were returned from 24 children and 50 adults. The median age at survey completion was 23 years (IQR [interquartile range] 15-51), and 51% were female. Among all 74 participants, 48 (65%) performed sports regularly. Children were vigorously active (median MET 9.1; IQR 7.9-9.6) and adults were moderately active (median MET 5.5; IQR 4.3-6.9). Fifty-nine participants (80%) reported performing some type of respiratory physiotherapy. However, only 30% of adults saw a professional physiotherapist, compared with 75% of children. Half of the participants had normal BMI; one child (4%) and two adults (4%) were underweight. People who were regularly physically active reported seeing a physiotherapist more often. CONCLUSIONS Our study is the first to provide patient-reported data about physical activity, respiratory physiotherapy and nutrition among people with primary ciliary dyskinesia. Our results highlight that professional respiratory physiotherapy, exercise recommendations and nutritional advice are often not implemented in the care of people with primary ciliary dyskinesia in Switzerland. Multidisciplinary care in specialised centres by teams including physiotherapists and nutrition consultants could improve the quality of life of people with primary ciliary dyskinesia

Physical activity, respiratory physiotherapy practices, and nutrition among people with primary ciliary dyskinesia in Switzerland – a cross-sectional survey

Aims of the study: We know little about the level of physical activity, respiratory physiotherapy practices and nutritional status of people with primary ciliary dyskinesia (PCD), although these are important aspects of patients with chronic respiratory disease. We assessed physical activity, respiratory physiotherapy practices and nutritional status among people with primary ciliary dyskinesia in Switzerland, investigated how these vary by age and identified factors associated with regular physical activity. Methods: We sent a postal questionnaire survey to people with primary ciliary dyskinesia enrolled in the Swiss PCD registry (CH-PCD), based on the standardised FOLLOW-PCD patient questionnaire. We collected information about physical activity, physiotherapy, respiratory symptoms and nutritional status. We calculated the metabolic equivalent (MET) to better reflect the intensity of the reported physical activities. To assess nutritional status, we extracted information from CH-PCD and calculated participants' body mass index (BMI). Results: Of the 86 questionnaires we sent, 74 (86% response rate) were returned from 24 children and 50 adults. The median age at survey completion was 23 years (IQR [interquartile range] 15-51), and 51% were female. Among all 74 participants, 48 (65%) performed sports regularly. Children were vigorously active (median MET 9.1; IQR 7.9-9.6) and adults were moderately active (median MET 5.5; IQR 4.3-6.9). Fifty-nine participants (80%) reported performing some type of respiratory physiotherapy. However, only 30% of adults saw a professional physiotherapist, compared with 75% of children. Half of the participants had normal BMI; one child (4%) and two adults (4%) were underweight. People who were regularly physically active reported seeing a physiotherapist more often. Conclusions: Our study is the first to provide patient-reported data about physical activity, respiratory physiotherapy and nutrition among people with primary ciliary dyskinesia. Our results highlight that professional respiratory physiotherapy, exercise recommendations and nutritional advice are often not implemented in the care of people with primary ciliary dyskinesia in Switzerland. Multidisciplinary care in specialised centres by teams including physiotherapists and nutrition consultants could improve the quality of life of people with primary ciliary dyskinesia

Respiratory symptoms of Swiss people with primary ciliary dyskinesia.

Background Mostly derived from chart reviews, where symptoms are recorded in a nonstandardised manner, clinical data about primary ciliary dyskinesia (PCD) are inconsistent, which leads to missing and unreliable information. We assessed the prevalence and frequency of respiratory and ear symptoms and studied differences by age and sex among an unselected population of Swiss people with PCD. Methods We sent a questionnaire that included items from the FOLLOW-PCD standardised questionnaire to all Swiss PCD registry participants. Results We received questionnaires from 74 (86%) out of 86 invited persons or their caregivers (median age 23 years, range 3-73 years), including 68% adults (≥18 years) and 51% females. Among participants, 70 (94%) reported chronic nasal symptoms; most frequently runny nose (65%), blocked nose (55%) or anosmia (38%). Ear pain and hearing problems were reported by 58% of the participants. Almost all (99%) reported cough and sputum production. The most common chronic cough complications were gastro-oesophageal reflux (n=11; 15%), vomiting (n=8; 11%) and urinary incontinence (n=6; 8%). Only nine (12%) participants reported frequent wheeze, which occurred mainly during infection or exercise, while 49 (66%) reported shortness of breath, and 9% even at rest or during daily activities. Older patients reported more frequent nasal symptoms and shortness of breath. We found no difference by sex or ultrastructural ciliary defect. Conclusion This is the first study to describe patient-reported PCD symptoms. The consistent collection of standardised clinical data will allow us to better characterise the phenotypic variability of the disease and study disease course and prognosis

Respiratory symptoms of Swiss people with primary ciliary dyskinesia

BACKGROUND Mostly derived from chart reviews, where symptoms are recorded in a nonstandardised manner, clinical data about primary ciliary dyskinesia (PCD) are inconsistent, which leads to missing and unreliable information. We assessed the prevalence and frequency of respiratory and ear symptoms and studied differences by age and sex among an unselected population of Swiss people with PCD. METHODS We sent a questionnaire that included items from the FOLLOW-PCD standardised questionnaire to all Swiss PCD registry participants. RESULTS We received questionnaires from 74 (86%) out of 86 invited persons or their caregivers (median age 23 years, range 3-73 years), including 68% adults (≥18 years) and 51% females. Among participants, 70 (94%) reported chronic nasal symptoms; most frequently runny nose (65%), blocked nose (55%) or anosmia (38%). Ear pain and hearing problems were reported by 58% of the participants. Almost all (99%) reported cough and sputum production. The most common chronic cough complications were gastro-oesophageal reflux (n=11; 15%), vomiting (n=8; 11%) and urinary incontinence (n=6; 8%). Only nine (12%) participants reported frequent wheeze, which occurred mainly during infection or exercise, while 49 (66%) reported shortness of breath, and 9% even at rest or during daily activities. Older patients reported more frequent nasal symptoms and shortness of breath. We found no difference by sex or ultrastructural ciliary defect. CONCLUSION This is the first study to describe patient-reported PCD symptoms. The consistent collection of standardised clinical data will allow us to better characterise the phenotypic variability of the disease and study disease course and prognosis

Internet of things–Enabled technologies as an intervention for childhood obesity: A systematic review

Childhood obesity is one of the most serious public health challenges of the 21st century, with consequences lasting into adulthood. Internet of Things (IoT)-enabled devices have been studied and deployed for monitoring and tracking diet and physical activity of children and adolescents as well as a means of providing remote, ongoing support to children and their families. This review aimed to identify and understand current advances in the feasibility, system designs, and effectiveness of IoT-enabled devices to support weight management in children. We searched Medline, PubMed, Web of Science, Scopus, ProQuest Central and the IEEE Xplore Digital Library for studies published after 2010 using a combination of keywords and subject headings related to health activity tracking, weight management, youth and Internet of Things. The screening process and risk of bias assessment were conducted in accordance with a previously published protocol. Quantitative analysis was conducted for IoT-architecture related findings and qualitative analysis was conducted for effectiveness-related measures. Twenty-three full studies are included in this systematic review. The most used devices were smartphone/mobile apps (78.3%) and physical activity data (65.2%) from accelerometers (56.5%) were the most commonly tracked data. Only one study embarked on machine learning and deep learning methods in the service layer. Adherence to IoT-based approaches was low but game-based IoT solutions have shown better effectiveness and could play a pivotal role in childhood obesity interventions. Researcher-reported effectiveness measures vary greatly amongst studies, highlighting the importance for improved development and use of standardised digital health evaluation frameworks.</jats:p