Fidgeting in Hong Kong adolescents and its associations with physical activity and weight status

Li Ka Shing Faculty of Medicine Frontiers SeriesSymposia Theme: ‘MOOCs in Postmodern Asia’ (Oct 27, 2014) and ‘Big Data and Precision Medicine’ (Oct 28, 2014)e-Posterpostprin

Assessing Transboundary-Local Aerosols Interaction Over Complex Terrain Using a Doppler LiDAR Network

This is the final version. Available from Wiley via the DOI in this recordData Availability Statement: Surface metrological data sets in Hong Kong are available at Hong Kong Observatory’s website: https://www.hko.gov.hk/en/cis/climat.htm. PM2.5 concentrations data sets can be obtained from Hong Kong Environmental Protection Department: https://www.aqhi.gov.hk/en.html. Processed 3DREAMS LiDAR data set and HKIA LiDAR data sets can be obtained in the repository: https://figshare.com/s/78e928f29c57ff86b5eeTransboundary-local aerosols interaction requires to be comprehensively understood in urban air quality research. A year-long intensive observation of the atmospheric boundary layer (ABL) at multiple sites in Hong Kong was conducted using a four-Doppler Light Detection and Ranging (LiDAR) network with different scanning modes. Results show that heterogeneity of the ABL in terms of mixing layer height and wind shear was induced by orographic topography. Interaction between local and advected aerosol layers during a transboundary air pollution (TAP) episode was identified by the network. During TAP episode, downward transport of transboundary aerosol relied on small scale eddies with weak wind speed in nighttime, while the transport of surface local aerosol to upper level was the dominated process in daytime, but the heterogeneity of the ABL affected by terrain determined the capacity of the mixing, eventually resulting in the opposite transport direction of aerosols in the transboundary-local aerosols interaction.Dr. Stanley Ho Medicine Development FoundationVice-Chancellor’s Discretionary Fund of The Chinese University of Hong Kon

Chimeric HBV/CCNE1 gene in hepatocellular carcinoma

Session 13.a: HCC Basic Science: abstract 2011Theme: Transforming Science to Clinical PracticeHepatocellular carcinoma (HCC) is the most common liver cancer worldwide and hepatitis B virus (HBV) infection remains the major etiological factor leading to high prevalence of HCC in Asia-Pacific regions. HBV carriers suffer from increa..

Overexpression of transferrin receptor CD71 and its tumorigenic properties in esophageal squamous cell carcinoma

Esophageal squamous cell carcinoma (ESCC) is the predominant type of esophageal cancer in endemic Asian regions. In the present study, we investigated the clinical implication and role of transferrin receptor CD71 in ESCC. CD71 has a physiological role in cellular iron intake and is implicated in the carcinogenesis of various types of tumors. In our cohort, more than a 2-fold upregulation of the CD71 transcript was detected in 61.5% of patients using quantitative polymerase chain reaction. Immunohistochemical analysis also showed strong membranous and cytoplasmic localization of CD71 in paraffin-embedded tumors. Staining parallel tumor sections with the proliferative marker Ki-67 revealed that the pattern of Ki-67 staining was associated with CD71 expression. Analysis of clinicopathological data indicated that CD71 overexpression can be used as an indicator for advanced T4 stage (P=0.0307). These data suggested a strong link between CD71 and ESCC. Subsequent in vitro assays using short interfering RNA (siRNA) to suppress CD71 expression confirmed the tumorigenic properties of CD71 in ESCC; cell growth inhibition and cell cycle arrest at S phase were observed in CD71-suppressed cells. The underlying mechanism involved activation of the MEK/ERK pathway. In summary, the present study provides evidence showing the tumorigenic properties of CD71 in ESCC with clinical correlations and suggests targeting CD71 as a strategy for the treatment of ESCC