" Développer une nouvelle approche pédagogique ", questionnement autour du cas de PicoLibre

International audienceCe papier s'intéresse à la problématique de mise en place d'une démarche pédagogique innovante dans le cadre des technologies de l'information et de la communication (TIC). Le sujet de cette analyse est une expérience qui a commencé voilà 2 à 3 ans au GET (Groupe des Ecoles des Télécommunication). Au terme de cette période, nous pointons un certain nombre d'observations et de réflexions par rapport à notre démarche même

Effect of the acrylic acid content on the permeability and water uptake of latex films

Acrylic acid (AA) is a monomer commonly employed in emulsion polymerization to provide electrostatic colloidal stability and improve specific film performance. The addition of AA not only modifies the kinetics of the polymerization, but also it takes part in the interaction between colloidal particles, which has a strong influence on their packing and consequent latex film properties. In this contribution a theoretical modeling of the latex film formation is presented and compared to experimental results: water vapor permeability and latex film capacitance are studied as a function of AA content. It has been shown that water uptake is mainly affected by film morphology which in turn is defined by intercolloidal interaction and drying rate.Comment: 16 pages, 7 figure

Rubber Cord Adhesion Inflation Test: Effect of constitutive rubber model on evaluation of Gc

The Rubber Cord Adhesion Inflation Test (RCAIT) is a recently proposed test protocol to study tyre rubber-steel cord fracture (Kane et al., 2019). As in the traditional blister test, a pressurised fluid is injected between the two adherends to propagate fracture. The fracture energy, Gc, is directly related to the strain energy stored in the inflated rubber. It was shown that evaluation of Gc for RCAIT depends intimately on how well the hyperelastic model is capable of predicting the rubber inflation condition (Kane et al., 2020). Here, a thick tube inflation model is proposed for a generalised, phenomenological, hyperelastic material. It is subsequently applied to RCAIT in order to study which data processing technique is likely to be the most reliable to evaluate the critical strain energy release rate of the specimen

Lysyl oxidase activity regulates oncogenic stress response and tumorigenesis

International audienceCellular senescence, a stable proliferation arrest, is induced in response to various stresses. Oncogenic stress-induced senescence (OIS) results in blocked proliferation and constitutes a fail-safe program counteracting tumorigenesis. The events that enable a tumor in a benign senescent state to escape from OIS and become malignant are largely unknown. We show that lysyl oxidase activity contributes to the decision to maintain senescence. Indeed, in human epithelial cell the constitutive expression of the LOX or LOXL2 protein favored OIS escape, whereas inhibition of lysyl oxidase activity was found to stabilize OIS. The relevance of these in vitro observations is supported by in vivo findings: in a transgenic mouse model of aggressive pancreatic ductal adenocarcinoma (PDAC), increasing lysyl oxidase activity accelerates senescence escape, whereas inhibition of lysyl oxidase activity was found to stabilize senescence, delay tumorigenesis, and increase survival. Mechanistically, we show that lysyl oxidase activity favors the escape of senescence by regulating the focal-adhesion kinase. Altogether, our results demonstrate that lysyl oxidase activity participates in primary tumor growth by directly impacting the senescence stability

Intermediate-conductance Ca2+-activated K+ channels (IKCa1) regulate human prostate cancer cell proliferation through a close control of calcium entry

International audienceAccumulating data point to K þ channels as relevant players in controlling cell cycle progression and proliferation of human cancer cells, including prostate cancer (PCa) cells. However, the mechanism(s) by which K þ channels control PCa cell proliferation remain illusive. In this study, using the techniques of molecular biology, biochemistry, electrophysiology and calcium imaging, we studied the expression and functionality of intermediate-conductance calcium-activated potassium channels (IK Ca1) in human PCa as well as their involvement in cell proliferation. We showed that IK Ca1 mRNA and protein were preferentially expressed in human PCa tissues, and inhibition of the IK Ca1 potassium channel suppressed PCa cell proliferation. The activation of IK Ca1 hyperpolarizes membrane potential and, by promoting the driving force for calcium, induces calcium entry through TRPV6, a cation channel of the TRP (Transient Receptor Potential) family. Thus, the overexpression of the IK Ca1 channel is likely to promote carcinogenesis in human prostate tissue

DEDICAT 6G - Dynamic coverage extension and distributed intelligence for human centric applications with assured security, privacy and trust:From 5G to 6G

5G networks offer unparalleled data rates and features. However these are still far from what a hyperconnected society and industry needs. Future wireless connectivity Beyond 5G (B5G)/6G will require a smart and green platform that is ultra-fast, highly adaptive, and dependable to support innovative, human-centric applications securely. This is the focus of the EU-funded DEDICAT 6G project, the vision and methodology of which is presented in this paper. DEDICAT 6G investigates enablers for dynamic distribution of intelligence to improve task execution time, energy efficiency, and ultimately, reduce end-to-end latency. The project also examines solutions for dynamic coverage extensions utilizing robots, connected vehicles and drones. The scope also comprises methods for security, privacy, and trust assurance including enablers for novel interaction between humans and digital systems exploiting innovative interfaces and devices, like smart glasses. DEDICAT 6G focuses on four representative 6G use cases: Smart Warehousing, Enhanced Experience, Public Safety and Smart Highway. The developed solutions will be demonstrated and tested in these use cases through experiments in laboratory environments, and larger field evaluations utilizing diverse assets and testing facilities. The aim is to derive results that will showcase substantial improvements in terms of intelligent network load balancing and resource allocation, extended coverage, enhanced security, privacy and trust and human-machine applications, </p