426 research outputs found

    PUK27 ERYTHROPOIESIS-STIMULATING AGENT DOSING AND HEMOGLOBIN TRENDS OVER TIME IN CHRONIC KIDNEY DISEASE PATIENTS NOT ON DIALYSIS

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    Pseudogap phase of cuprate superconductors confined by Fermi surface topology

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    The properties of cuprate high-temperature superconductors are largely shaped by competing phases whose nature is often a mystery. Chiefly among them is the pseudogap phase, which sets in at a doping p∗p^* that is material-dependent. What determines p∗p^* is currently an open question. Here we show that the pseudogap cannot open on an electron-like Fermi surface, and can only exist below the doping pFSp_{FS} at which the large Fermi surface goes from hole-like to electron-like, so that p∗p^* ≤\leq pFSp_{FS}. We derive this result from high-magnetic-field transport measurements in La1.6−x_{1.6-x}Nd0.4_{0.4}Srx_xCuO4_4 under pressure, which reveal a large and unexpected shift of p∗p^* with pressure, driven by a corresponding shift in pFSp_{FS}. This necessary condition for pseudogap formation, imposed by details of the Fermi surface, is a strong constraint for theories of the pseudogap phase. Our finding that p∗p^* can be tuned with a modest pressure opens a new route for experimental studies of the pseudogap.Comment: 15 pages, 5 figures, 7 supplemental figure

    Field-angle dependence of sound velocity in the Weyl semimetal TaAs

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    The elastic modulus c44c_{44} of a single crystal of the Weyl semimetal TaAs was investigated by measuring relative changes in the sound velocity under application of a magnetic field up to 10 T. Using an ultrasonic pulsed-echo technique, we studied the shear response of the crystal when the angle between the sound wave propagation and the magnetic field is changed. We observe a broken tetragonal symmetry at fields above 6 T, an anisotropy that is likely related to a longitudinal negative magnetoresistance and therefore might provide evidence of the chiral anomaly, one of the main topological signatures of this class of materials. We also observe quantum oscillations in the sound velocity whose frequencies vary with magnetic field orientation. A fan diagram of Landau level indices reveals topological and trivial Berry phases, depending on the field orientation, indicating a sensitivity to different Fermi surface pockets that do or do not enclose Weyl nodes respectively

    Field-dependent heat transport in the Kondo insulator SmB6 : phonons scattered by magnetic impurities

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    The thermal conductivity κ\kappa of the Kondo insulator SmB6_6 was measured at low temperature, down to 70 mK, in magnetic fields up to 15 T, on single crystals grown using both the floating-zone and the flux methods. The residual linear term κ0/T\kappa_0/T at T→0T \to 0 is found to be zero in all samples, for all magnetic fields, in agreement with previous studies. There is therefore no clear evidence of fermionic heat carriers. In contrast to some prior data, we observe a large enhancement of κ(T)\kappa(T) with increasing field. The effect of field is anisotropic, depending on the relative orientation of field and heat current (parallel or perpendicular), and with respect to the cubic crystal structure. We interpret our data in terms of heat transport predominantly by phonons, which are scattered by magnetic impurities.Comment: publish versio

    What historical landfast ice observations tell us about projected ice conditions in Arctic archipelagoes and marginal seas under anthropogenic forcing

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    Arctic landfast ice extent and duration are examined from observations, ice assimilations, ocean reanalyses and coupled models. From observations and assimilations, it is shown that in areas where landfast ice conditions last more than 5 months the first-year ice typically grows to more than 2&thinsp;m and is rarely less than 1&thinsp;m. The observed spatial distribution of landfast ice closely matches assimilation products but less so for ocean reanalyses and coupled models. Although models generally struggle to represent the landfast ice necessary to emulate the observed import/export of sea ice in regions favourable to landfast ice conditions, some do exhibit both a realistic climatology and a realistic decline of landfast ice extent under an anthropogenic forcing scenario. In these more realistic simulations, projections show that an extensive landfast ice cover should remain for at least 5 months of the year, well into the end of the 21st century. This is in stark contrast with the simulations that have an unrealistic emulation of landfast ice conditions. In these simulations, slow and packed ice conditions shrink markedly over the same period. In all simulations and in areas with landfast ice that lasts more than 5 months, the end-of-winter sea ice thickness remains between 1 and 2&thinsp;m, well beyond the second half of the century. It is concluded that in the current generation of climate models, projections of winter sea ice conditions in the Canadian Arctic Archipelago and the Laptev Sea are overly sensitive to the representation of landfast ice conditions and that ongoing development in landfast ice parameterization will likely better constrain these projections.</p

    Secretion of functional papain precursor from insect cells. Requirement for N-glycosylation of the pro-region.

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    The synthetic gene coding for the precursor of the cysteine protease papain (EC 3.4.22.2) has been expressed using the baculovirus/insect cell system. The prepropapain gene was cloned into the transfer vector IpDC125 behind the polyhedrin promoter. The recombinant construct was then incorporated by homologous recombination into the Autographa californiaca nuclear polyhedrosis virus genome. The host Spodoptera frugiperda Sf9 cells infected with the recombinant baculovirus secrete an enzymatically inactive N-glycosylated papain precursor. This zymogen could be activated in vitro to yield about 400 nmol of active papain per liter of culture. The recombinant active mature papain was enzymatically indistinguishable from natural papain but the precursor was not processed to the same amino acid residue. The insect cells also accumulated prepropapain and glycosylated propapain intracellularly. This accumulation was an indication that there are rate-limiting steps in the secretion of proteins from insect cells in this expression system. Characterization of mutants of the precursor has shown that entry into the secretory pathway and addition of carbohydrate are prerequisite conditions for the production and secretion of functional propapain
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