97 research outputs found
A two-mass expanding exact space-time solution
In order to understand how locally static configurations around
gravitationally bound bodies can be embedded in an expanding universe, we
investigate the solutions of general relativity describing a space-time whose
spatial sections have the topology of a 3-sphere with two identical masses at
the poles. We show that Israel junction conditions imply that two spherically
symmetric static regions around the masses cannot be glued together. If one is
interested in an exterior solution, this prevents the geometry around the
masses to be of the Schwarzschild type and leads to the introduction of a
cosmological constant. The study of the extension of the Kottler space-time
shows that there exists a non-static solution consisting of two static regions
surrounding the masses that match a Kantowski-Sachs expanding region on the
cosmological horizon. The comparison with a Swiss-Cheese construction is also
discussed.Comment: 15 pages, 5 figures. Replaced to match the published versio
Vortex Rings in two Component Bose-Einstein Condensates
We study the structure of the vortex core in two-component Bose-Einstein
condensates. We demonstrate that the order parameter may not vanish and the
symmetry may not be restored in the core of the vortex. In this case such
vortices can form vortex rings known as vortons in particle physics literature.
In contrast with well-studied superfluid , where similar vortex rings can
be stable due to Magnus force only if they move, the vortex rings in
two-component BECs can be stable even if they are at rest. This beautiful
effect was first discussed by Witten in the cosmic string context, where it was
shown that the stabilization occurs due to condensation of the second component
of the field in the vortex core. This second condensate trapped in the core may
carry a current along the vortex ring counteracting the effect of string
tension that causes the loop to shrink. We speculate that such vortons may have
been already observed in the laboratory. We also speculate that the
experimental study of topological structures in BECs can provide a unique
opportunity to study cosmology and astrophysics by doing laboratory
experiments.Comment: 21 pages, 2 figure
Competing orders in a magnetic field: spin and charge order in the cuprate superconductors
We describe two-dimensional quantum spin fluctuations in a superconducting
Abrikosov flux lattice induced by a magnetic field applied to a doped Mott
insulator. Complete numerical solutions of a self-consistent large N theory
provide detailed information on the phase diagram and on the spatial structure
of the dynamic spin spectrum. Our results apply to phases with and without
long-range spin density wave order and to the magnetic quantum critical point
separating these phases. We discuss the relationship of our results to a number
of recent neutron scattering measurements on the cuprate superconductors in the
presence of an applied field. We compute the pinning of static charge order by
the vortex cores in the `spin gap' phase where the spin order remains
dynamically fluctuating, and argue that these results apply to recent scanning
tunnelling microscopy (STM) measurements. We show that with a single typical
set of values for the coupling constants, our model describes the field
dependence of the elastic neutron scattering intensities, the absence of
satellite Bragg peaks associated with the vortex lattice in existing neutron
scattering observations, and the spatial extent of charge order in STM
observations. We mention implications of our theory for NMR experiments. We
also present a theoretical discussion of more exotic states that can be built
out of the spin and charge order parameters, including spin nematics and phases
with `exciton fractionalization'.Comment: 36 pages, 33 figures; for a popular introduction, see
http://onsager.physics.yale.edu/superflow.html; (v2) Added reference to new
work of Chen and Ting; (v3) reorganized presentation for improved clarity,
and added new appendix on microscopic origin; (v4) final published version
with minor change
Spin Susceptibility in Underdoped
We report a comprehensive polarized and unpolarized neutron scattering study
of the evolution of the dynamical spin susceptibility with temperature and
doping in three underdoped single crystals of the \YBCO{6+x} high temperature
superconductor: \YBCO{6.5} (Tc = 52 K), \YBCO{6.7} (Tc = 67 K), and \YBCO{6.85}
(T_c = 87 K). Theoretical implications of these data are discussed, and a
critique of recent attempts to relate the spin excitations to the
thermodynamics of high temperature superconductors is given.Comment: minor revisions, to appear in PR
Low-frequency dilatational wave propagation through unsaturated porous media containing two immiscible fluids
Reforming Watershed Restoration: Science in Need of Application and Applications in Need of Science
Effect of short period feed supplementation during early lactation on performance of cows and calves raised in extensive system
Para-infectious brain injury in COVID-19 persists at follow-up despite attenuated cytokine and autoantibody responses
To understand neurological complications of COVID-19 better both acutely and for recovery, we measured markers of brain injury, inflammatory mediators, and autoantibodies in 203 hospitalised participants; 111 with acute sera (1–11 days post-admission) and 92 convalescent sera (56 with COVID-19-associated neurological diagnoses). Here we show that compared to 60 uninfected controls, tTau, GFAP, NfL, and UCH-L1 are increased with COVID-19 infection at acute timepoints and NfL and GFAP are significantly higher in participants with neurological complications. Inflammatory mediators (IL-6, IL-12p40, HGF, M-CSF, CCL2, and IL-1RA) are associated with both altered consciousness and markers of brain injury. Autoantibodies are more common in COVID-19 than controls and some (including against MYL7, UCH-L1, and GRIN3B) are more frequent with altered consciousness. Additionally, convalescent participants with neurological complications show elevated GFAP and NfL, unrelated to attenuated systemic inflammatory mediators and to autoantibody responses. Overall, neurological complications of COVID-19 are associated with evidence of neuroglial injury in both acute and late disease and these correlate with dysregulated innate and adaptive immune responses acutely
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
BACKGROUND: Most studies of immunity to SARS-CoV-2 focus on circulating antibody, giving limited insights into mucosal defences that prevent viral replication and onward transmission. We studied nasal and plasma antibody responses one year after hospitalisation for COVID-19, including a period when SARS-CoV-2 vaccination was introduced. METHODS: In this follow up study, plasma and nasosorption samples were prospectively collected from 446 adults hospitalised for COVID-19 between February 2020 and March 2021 via the ISARIC4C and PHOSP-COVID consortia. IgA and IgG responses to NP and S of ancestral SARS-CoV-2, Delta and Omicron (BA.1) variants were measured by electrochemiluminescence and compared with plasma neutralisation data. FINDINGS: Strong and consistent nasal anti-NP and anti-S IgA responses were demonstrated, which remained elevated for nine months (p < 0.0001). Nasal and plasma anti-S IgG remained elevated for at least 12 months (p < 0.0001) with plasma neutralising titres that were raised against all variants compared to controls (p < 0.0001). Of 323 with complete data, 307 were vaccinated between 6 and 12 months; coinciding with rises in nasal and plasma IgA and IgG anti-S titres for all SARS-CoV-2 variants, although the change in nasal IgA was minimal (1.46-fold change after 10 months, p = 0.011) and the median remained below the positive threshold determined by pre-pandemic controls. Samples 12 months after admission showed no association between nasal IgA and plasma IgG anti-S responses (R = 0.05, p = 0.18), indicating that nasal IgA responses are distinct from those in plasma and minimally boosted by vaccination. INTERPRETATION: The decline in nasal IgA responses 9 months after infection and minimal impact of subsequent vaccination may explain the lack of long-lasting nasal defence against reinfection and the limited effects of vaccination on transmission. These findings highlight the need to develop vaccines that enhance nasal immunity. FUNDING: This study has been supported by ISARIC4C and PHOSP-COVID consortia. ISARIC4C is supported by grants from the National Institute for Health and Care Research and the Medical Research Council. Liverpool Experimental Cancer Medicine Centre provided infrastructure support for this research. The PHOSP-COVD study is jointly funded by UK Research and Innovation and National Institute of Health and Care Research. The funders were not involved in the study design, interpretation of data or the writing of this manuscript
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