Sliding mode approach for control and observation of a three phase AC-DC pulse-width modulation rectifier

Introduction. For AC-DC conversion systems, the electrical systems typically use thyristor or diode bridge rectifiers, which have relatively poor performance. Nowadays, three-phase pulse-width modulation rectifiers are widely applied in various applications for their well-known intrinsic benefits, such as adjustable DC link voltage, unity power factor, bidirectional power flow and very low total harmonic distortion. Purpose. The objective of this work is to achieve better stability and dynamic performance using sliding mode strategy for control and observation. Methods. For that purpose, first a sliding mode controller is introduced on the DC-link side to ensure a fast and accurate response of the output load voltage. Then, the sliding mode approach is employed to control the quadrature and direct components of power to maintain the input power factor at unity. Finally, this approach is used to design two observers for grid voltage estimation and online variation of load resistance. To overcome the problem associated with the use of the classical low-pass filter, an adaptive compensation algorithm is used to compensate the attenuation of the amplitude and phase delay of the observed grid voltages. This algorithm is based on the use of the two low-pass filters in cascade and ensures the minimization of chattering. Results. Comparative studies have been carried out between sliding mode control method for controlling the three-phase AC-DC pulse-width modulation rectifier and other conventional techniques. The validation by simulation and the tests carried out gave very satisfactory results and proved the effectiveness and feasibility of the sliding mode for both control and observation of three phase pulse-width modulation rectifier.Вступ. Для AC-DC систем перетворення електричні системи зазвичай використовують тиристорні або діодні мостові випрямлячі, які мають відносно погані характеристики. В даний час трифазні випрямлячі з широтно-імпульсною модуляцією широко застосовуються з різними цілями завдяки їх добре відомим внутрішнім перевагам, таким як регульована напруга у ланці постійного струму, одиничний коефіцієнт потужності, двонаправлений потік потужності та дуже низькі загальні гармонічні спотворення. Метою даної роботи є досягнення кращої стабільності та динамічних характеристик з використанням стратегії ковзного режиму для контролю та спостереження. Методи. З цією метою спочатку на стороні ланки постійного струму вводиться регулятор режиму ковзання, щоб забезпечити швидку і точну реакцію на вихідну напругу навантаження. Потім використовується метод ковзного режиму для управління квадратурною та прямою складовими потужності, щоб підтримувати вхідний коефіцієнт потужності рівним одиниці. Нарешті цей підхід використовується для розробки двох спостерігачів для оцінки напруги мережі та зміни опору навантаження в режимі онлайн. Для подолання проблеми, пов'язаної з використанням класичного низькочастотного фільтру, використовується алгоритм адаптивної компенсації, що компенсує загасання амплітуди і фазової затримки напруг мережі, що спостерігаються. Цей алгоритм заснований на використанні двох низькочастотних фільтрів у каскаді та забезпечує мінімізацію брязкоту. Результати. Були проведені порівняльні дослідження між методом керування ковзним режимом для керування трифазним випрямлячем AC-DC з широтно-імпульсною модуляцією та іншими традиційними методами. Перевірка за допомогою моделювання та проведені випробування дали дуже задовільні результати та довели ефективність та здійсненність ковзного режиму як для управління, так і для спостереження за трифазним випрямлячем з широтно-імпульсною модуляцією

Mild cognitive impairment is associated with poor physical function but not bone structure or density in late adulthood:Findings from the Hertfordshire Cohort Study

Mini Abstract This study investigated the association between mild cognitive impairment (MCI) and physical function and bone health in older adults. MCI was associated with poor physical performance but not bone mineral density or bone microarchitecture. Abstract Purpose: Cross-sectional study to investigate the association between mild cognitive impairment (MCI) and physical performance, and bone health, in a community-dwelling cohort of older adults. Methods: Cognitive function of 222 men and 221 women (mean age 75.5 and 75.8 years in men and women, respectively) was assessed by the Strawbridge questionnaire and Mini Mental State Exam (MMSE). Participants underwent dual-energy x-ray absorptiometry (DXA), peripheral-quantitative computed tomography (pQCT) and high-resolution peripheral-quantitative computed tomography (HR-pQCT) scans to assess their bone density, strength and microarchitecture. Their physical function was assessed and a physical performance (PP) score was recorded. Results: 11.8% of women and 8.1% of men in the study were cognitive impaired on the MMSE (score<24). 24% of women were deemed cognitively impaired on the Strawbridge questionnaire, compared to 22.3% of men. Cognitive impairment on the Strawbridge questionnaire was associated with poorer physical performance score in men but not women in the unadjusted analysis. MMSE <24 was strongly associated with the risk of low physical performance in men (OR 12.9, 95% CI 1.67, 99.8, p=0.01) Higher MMSE score was associated with better physical performance in both sexes. Poorer cognitive function, whether assessed by the Strawbridge questionnaire, or by MMSE score, was not associated with bone density, shape or microarchitecture, in either sex. Conclusion: MCI in older adults was associated with poor physical performance, but not bone density, shape or microarchitecture

Advanced CT bone imaging in osteoporosis

Non-invasive and/or non-destructive techniques can provide structural information about bone, beyond simple bone densitometry. While the latter provides important information about osteoporotic fracture risk, many studies indicate that BMD only partly explains bone strength. Quantitative assessment of macro- and microstructural features may improve our ability to estimate bone strength. Methods for quantitatively assessing macrostructure include (besides conventional radiographs) DXA and CT, particularly volumetric quantitative CT (vQCT). Methods for assessing microstructure of trabecular bone non-invasively and/or non-destructively include high-resolution CT (hrCT), microCT (μCT), high-resolution magnetic resonance (hrMR) and microMR (μMR). vQCT, hrCT and hrMR are generally applicable in vivo; μCT and μMR are principally applicable in vitro. Despite recent progress made with these advanced imaging techniques, certain issues remain. The important balances between spatial resolution and sampling size, or between signal-to-noise and radiation dose or acquisition time, need further consideration, as do the complexity and expense of the methods vs their availability and accessibility. Clinically, the challenges for bone imaging include balancing the advantages of simple bone densitometry vs the more complex architectural features of bone or the deeper research requirements vs the broader clinical needs. The biological differences between the peripheral appendicular skeleton and the central axial skeleton must be further addressed. Finally, the relative merits of these sophisticated imaging techniques must be weighed with respect to their applications as diagnostic procedures, requiring high accuracy or reliability, compared with their monitoring applications, requiring high precision or reproducibility

Synergistic Inhibition of Endothelial Cell Proliferation, Tube Formation, and Sprouting by Cyclosporin A and Itraconazole

Pathological angiogenesis contributes to a number of diseases including cancer and macular degeneration. Although angiogenesis inhibitors are available in the clinic, their efficacy against most cancers is modest due in part to the existence of alternative and compensatory signaling pathways. Given that angiogenesis is dependent on multiple growth factors and a broad signaling network in vivo, we sought to explore the potential of multidrug cocktails for angiogenesis inhibition. We have screened 741 clinical drug combinations for the synergistic inhibition of endothelial cell proliferation. We focused specifically on existing clinical drugs since the re-purposing of clinical drugs allows for a more rapid and cost effective transition to clinical studies when compared to new drug entities. Our screen identified cyclosporin A (CsA), an immunosuppressant, and itraconazole, an antifungal drug, as a synergistic pair of inhibitors of endothelial cell proliferation. In combination, the IC50 dose of each drug is reduced by 3 to 9 fold. We also tested the ability of the combination to inhibit endothelial cell tube formation and sprouting, which are dependent on two essential processes in angiogenesis, endothelial cell migration and differentiation. We found that CsA and itraconazole synergistically inhibit tube network size and sprout formation. Lastly, we tested the combination on human foreskin fibroblast viability as well as Jurkat T cell and HeLa cell proliferation, and found that endothelial cells are selectively targeted. Thus, it is possible to combine existing clinical drugs to synergistically inhibit in vitro models of angiogenesis. This strategy may be useful in pursuing the next generation of antiangiogenesis therapy

Bone Degeneration and Recovery after Early and Late Bisphosphonate Treatment of Ovariectomized Wistar Rats Assessed by In Vivo Micro-Computed Tomography

Bisphosphonates are antiresorptive drugs commonly used to treat osteoporosis. It is not clear, however, what the influence of the time point of treatment is. Recently developed in vivo micro-computed tomographic (CT) scanners offer the possibility to study such effects on bone microstructure in rats. The aim of this study was to determine the influence of early and late zoledronic acid treatment on bone in ovariectomized rats, using in vivo micro-CT. Twenty-nine female Wistar rats were divided into the following groups: ovariectomy (OVX, n = 5), OVX and zoledronic acid (ZOL) at week 0 (n = 8), OVX and ZOL at week 8 (n = 7), and sham (n = 9). CT scans were made of the proximal tibia at weeks 0, 2, 4, 8, 12, and 16; and bone structural parameters were determined in the metaphysis. Two fluorescent labels were administered to calculate dynamic histomorphometric parameters. At week 16, all groups were significantly different from each other in bone volume fraction (BV/TV), connectivity density, and trabecular number (Tb.N), except for the early ZOL and control groups which were not significantly different for any structural parameter. After ZOL treatment at week 8, BV/TV, structure model index, Tb.N, and trabecular thickness significantly improved in the late ZOL group. The OVX and ZOL groups showed, respectively, higher and lower bone formation rates than the control group. Early ZOL treatment inhibited all bone microstructural changes seen after OVX. Late ZOL treatment significantly improved bone microstructure, although the structure did not recover to original levels. Early ZOL treatment resulted in a significantly better microstructure than late treatment. However, late treatment was still significantly better than no treatment