Depression and anxiety in prostate cancer: a systematic review and meta-analysis of prevalence rates

ObjectivesTo systematically review the literature pertaining to the prevalence of depression and anxiety in patients with prostate cancer as a function of treatment stage.DesignSystematic review and meta-analysis.Participants4494 patients with prostate cancer from primary research investigations.Primary outcome measureThe prevalence of clinical depression and anxiety in patients with prostate cancer as a function of treatment stage.ResultsWe identified 27 full journal articles that met the inclusion criteria for entry into the meta-analysis resulting in a pooled sample size of 4494 patients. The meta-analysis of prevalence rates identified pretreatment, on-treatment and post-treatment depression prevalences of 17.27% (95% CI 15.06% to 19.72%), 14.70% (95% CI 11.92% to 17.99%) and 18.44% (95% CI 15.18% to 22.22%), respectively. Pretreatment, on-treatment and post-treatment anxiety prevalences were 27.04% (95% CI 24.26% to 30.01%), 15.09% (95% CI 12.15% to 18.60%) and 18.49% (95% CI 13.81% to 24.31%), respectively.ConclusionsOur findings suggest that the prevalence of depression and anxiety in men with prostate cancer, across the treatment spectrum, is relatively high. In light of the growing emphasis placed on cancer survivorship, we consider that further research within this area is warranted to ensure that psychological distress in patients with prostate cancer is not underdiagnosed and undertreated

Spatiotemporal Patterns and Predictability of Cyberattacks

Y.C.L. was supported by Air Force Office of Scientific Research (AFOSR) under grant no. FA9550-10-1-0083 and Army Research Office (ARO) under grant no. W911NF-14-1-0504. S.X. was supported by Army Research Office (ARO) under grant no. W911NF-13-1-0141. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.Peer reviewedPublisher PD

Two-dimensional viscous flow computations of hypersonic scramjet nozzle flowfields at design and off-design conditions

The PARC2D code has been selected to analyze the flowfields of a representative hypersonic scramjet nozzle over a range of flight conditions from Mach 3 to 20. The flowfields, wall pressures, wall skin friction values, heat transfer values and overall nozzle performance are presented

A compressible near-wall turbulence model for boundary layer calculations

A compressible near-wall two-equation model is derived by relaxing the assumption of dynamical field similarity between compressible and incompressible flows. This requires justifications for extending the incompressible models to compressible flows and the formulation of the turbulent kinetic energy equation in a form similar to its incompressible counterpart. As a result, the compressible dissipation function has to be split into a solenoidal part, which is not sensitive to changes of compressibility indicators, and a dilational part, which is directly affected by these changes. This approach isolates terms with explicit dependence on compressibility so that they can be modeled accordingly. An equation that governs the transport of the solenoidal dissipation rate with additional terms that are explicitly dependent on the compressibility effects is derived similarly. A model with an explicit dependence on the turbulent Mach number is proposed for the dilational dissipation rate. Thus formulated, all near-wall incompressible flow models could be expressed in terms of the solenoidal dissipation rate and straight-forwardly extended to compressible flows. Therefore, the incompressible equations are recovered correctly in the limit of constant density. The two-equation model and the assumption of constant turbulent Prandtl number are used to calculate compressible boundary layers on a flat plate with different wall thermal boundary conditions and free-stream Mach numbers. The calculated results, including the near-wall distributions of turbulence statistics and their limiting behavior, are in good agreement with measurements. In particular, the near-wall asymptotic properties are found to be consistent with incompressible behavior; thus suggesting that turbulent flows in the viscous sublayer are not much affected by compressibility effects

A near-wall two-equation model for compressible turbulent flows

A near-wall two-equation turbulence model of the K - epsilon type is developed for the description of high-speed compressible flows. The Favre-averaged equations of motion are solved in conjunction with modeled transport equations for the turbulent kinetic energy and solenoidal dissipation wherein a variable density extension of the asymptotically consistent near-wall model of So and co-workers is supplemented with new dilatational models. The resulting compressible two-equation model is tested in the supersonic flat plate boundary layer - with an adiabatic wall and with wall cooling - for Mach numbers as large as 10. Direct comparisons of the predictions of the new model with raw experimental data and with results from the K - omega model indicate that it performs well for a wide range of Mach numbers. The surprising finding is that the Morkovin hypothesis, where turbulent dilatational terms are neglected, works well at high Mach numbers, provided that the near wall model is asymptotically consistent. Instances where the model predictions deviate from the experiments appear to be attributable to the assumption of constant turbulent Prandtl number - a deficiency that will be addressed in a future paper

Squeezing and entanglement of matter-wave gap solitons

We study quantum squeezing and entanglement of gap solitons in a Bose-Einstein condensate loaded into a one-dimensional optical lattice. By employing a linearized quantum theory we find that quantum noise squeezing of gap solitons, produced during their evolution, is enhanced compared with the atomic solitons in a lattice-free case due to intra-soliton structure of quantum correlations induced by the Bragg scattering in the periodic potential. We also show that nonlinear interaction of gap solitons in dynamically stable bound states can produce strong soliton entanglement.Comment: 4 pages, 5 figure

On the Possible Enhancement of the Magnetic Field by Neutrino Reemission Processes in the Mantle of a Supernova

URCA neutrino reemission processes under the conditions in the mantle of a supernova with a strong toroidal magnetic field are investigated. It is shown that parity violation in these processes can be manifested macroscopically as a torque that rapidly spins up the region of the mantle occupied by such a field. Neutrino spin-up of the mantle can strongly affect the mechanism of further generation of the toroidal field, specifically, it can enhance the field in a small neighborhood of the rigid-body-rotating core of the supernova remnant.Comment: 8 pages, late

Polarized X-rays from Magnetized Neutron Stars

We review the polarization properties of X-ray emission from highly magnetized neutron stars, focusing on emission from the stellar surfaces. We discuss how x-ray polarization can be used to constrain neutron star magnetic field and emission geometry, and to probe strong-field quantum electrodynamics and possibly constrain the properties of axions.Comment: to appear in "X-ray Polarimetry: A New Window in Astrophysics", edited by R. Bellazzini, E. Costa, G. Matt and G. Tagliaferri (Cambridge University Press