1,593 research outputs found
How do bidders’ organism reactions mediate auction stimuli and bidder loyalty in online auctions? The case of Taobao in China
© 2016 Elsevier B.V.Currently, it is critical to nurture bidder loyalty in the highly competitive online auction business. This study investigated the mediating effect of consumer perceptions between technological/brand stimuli and bidder loyalty to an online auction website by applying the traditional and evolutionary stimulus-organism-response models. We tested these models using 449 bidders from Taobao, an online auction service provider in China. Based on the results of covariance-based structural equation modelling, we showed that consumer perceptions fully mediate technological stimuli, but only partially mediate brand stimuli, and bidder loyalty. These results can be used to further improve the related research and practice.Link_to_subscribed_fulltex
Role of polymorphisms of the inflammatory response genes and DC-SIGNR in genetic susceptibility to SARS and other infections.
Research Fund for the Control of Infectious Diseases: Research Dissemination Reports (Series 2)1. A genetic risk-association study involving more than 1200 subjects showed individuals homozygous for L-SIGN tandem repeats are less susceptible to SARS infection. 2. This was supported by in vitro binding studies that demonstrated homozygous L-SIGN, compared to heterozygous, had higher binding capacity for SARS coronavirus (SARS-CoV), with higher proteasome-dependent viral degradation. In contrast, homozygous L-SIGN demonstrated lower binding capacity for HIV1-gp120.3. Genetic-association studies for single nucleotide polymorphisms of the inflammatory response genes, namely TNF-alpha, INF-alpha, INF-beta, INF-gamma, IL1-alpha, IL1-beta, IL-4, IL-6 and iNOS, failed to show a significant association with SARS clinical outcomes or susceptibility.published_or_final_versio
Understanding social inequalities in children being bullied: UK Millennium Cohort Study findings
BACKGROUND: Children living in disadvantaged socio-economic circumstances (SEC) are more commonly victims of bullying, but pathways leading to social inequalities in being bullied are unclear. We assess how early life risk factors might mediate the increased risk of being bullied at age seven for children living in disadvantaged circumstances. MATERIAL AND METHODS: Using data from 5,857 children in the UK Millennium Cohort Study (MCS) we calculate risk ratios (RR) for being bullied at age seven (child-reported), by household income quintile. Socially patterned risk factors for being bullied relating to social networks, family relationships and child characteristics from birth to age five were adjusted for to assess if they mediated any association between SEC and being bullied. RESULTS: 48.6% of children reported having been bullied. Children living in the lowest income households were at 20% greater risk of being bullied compared to those from the highest (RR1.20, 95%CI 1.06,1.36). Controlling for social networks, family relationships and child characteristics attenuated the increased risk for children in low income households to aRR 1.19 (95%CI 1.05, 1.35), aRR 1.16 (95%CI 1.02,1.32) and aRR 1.13 (95%CI 1.00,1.28) respectively. Our final model adjusted for risk factors across all domains attenuated the RR by 45% (aRR 1.11,95%CI 0.97,1.26). CONCLUSIONS: About half of children reported being bullied by age seven with a clear social gradient. The excess risk in children growing up in disadvantaged circumstances was partially explained by differences in their early years relating to their social network, family relationships and the child’s own abilities and behaviours. Policies to reduce inequalities in these risk factors may also reduce inequalities in the risk of being bullied in childhood
Functional role of ICAM-3 polymorphism in genetic susceptibility to SARS infection.
Key Messages 1. Severe acute respiratory syndrome (SARS) patients who are homozygous for intercellular adhesion molecule-3 (ICAM-3) Gly143 showed significant association with higher lactate dehydrogenase levels and lower total white blood cell counts on admission. 2. In vitro functional studies demonstrated low level binding of ICAM-3 to DC-SIGN and a wide variation in T-cell response of the wild-type ICAM-3 genotype.published_or_final_versio
Association of a single nucleotide polymorphism in the CD209 (DC-SIGN) promoter with SARS severity.
published_or_final_versio
Phenomenology of event shapes at hadron colliders
We present results for matched distributions of a range of dijet event shapes
at hadron colliders, combining next-to-leading logarithmic (NLL) accuracy in
the resummation exponent, next-to-next-to leading logarithmic (NNLL) accuracy
in its expansion and next-to-leading order (NLO) accuracy in a pure alpha_s
expansion. This is the first time that such a matching has been carried out for
hadronic final-state observables at hadron colliders. We compare our results to
Monte Carlo predictions, with and without matching to multi-parton tree-level
fixed-order calculations. These studies suggest that hadron-collider event
shapes have significant scope for constraining both perturbative and
non-perturbative aspects of hadron-collider QCD. The differences between
various calculational methods also highlight the limits of relying on
simultaneous variations of renormalisation and factorisation scale in making
reliable estimates of uncertainties in QCD predictions. We also discuss the
sensitivity of event shapes to the topology of multi-jet events, which are
expected to appear in many New Physics scenarios.Comment: 70 pages, 25 figures, additional material available from
http://www.lpthe.jussieu.fr/~salam/pp-event-shapes
The need for nursing instruction in patients receiving steroid pulse therapy for the treatment of autoimmune diseases and the effect of instruction on patient knowledge
<p>Abstract</p> <p>Background</p> <p>Many patients who receive steroid pulse therapy go home the same day or the day after steroid administration. Nursing instructions are important for improving patient knowledge related to their diseases and treatments, but the short hospital stay often prevents complete education and guidance regarding the given therapy. The purpose of this study was to investigate the need for nursing instruction in patients receiving steroid pulse therapy for the treatment of autoimmune diseases and the effect of instruction on patient knowledge of their disease and treatment.</p> <p>Methods</p> <p>Patients with systemic lupus erythematosus (SLE) and systemic sclerosis receiving steroid pulse therapy (N = 63) were recruited from a medical center in Taipei. A structured questionnaire was used for data collection before and after nursing instruction, and 1 week as well as 2 weeks after therapy. The need for nursing instruction and knowledge levels were validated using Cronbach's α reliability test.</p> <p>Results</p> <p>There was a significant difference (<it>P </it>< 0.001) in the need for nursing instruction among the 4 time points. There was a positive correlation between the need for nursing instruction and body weight change, frequency of treatment, and distress, but there was a negative correlation with knowledge level (β = -0.012, <it>P </it>= 0.003) regarding symptoms. The knowledge level of subjects after nursing instruction was significantly higher than before nursing instruction (80 ± 14.31 vs. 70.06 ± 17.23, <it>P </it>< 0.001).</p> <p>Conclusions</p> <p>This study indicates that nursing instruction is needed by patients receiving steroid pulse therapy, and that by designing and administering nursing instructions according to the priority of patient symptoms, nurses can improve patient knowledge related to their diseases and treatments. In addition, the need for nursing instruction can be affected by patient characteristics.</p
Parton distributions with small-x resummation:evidence for BFKL dynamics in HERA data
We present a determination of the parton distribution functions of the proton
in which NLO and NNLO fixed-order calculations are supplemented by NLLx small-x
resummation. Deep inelastic structure functions are computed consistently at
NLO+NLLx or NNLO+NLLx, while for hadronic processes small-x resummation is
included only in the PDF evolution, with kinematic cuts introduced to ensure
the fitted data lie in a region where the fixed-order calculation of the hard
cross-sections is reliable. In all other respects, the fits use the same
methodology and are based on the same global dataset as the recent NNPDF3.1
analysis. We demonstrate that the inclusion of small-x resummation leads to a
quantitative improvement in the perturbative description of the HERA inclusive
and charm-production reduced cross-sections in the small x region. The impact
of the resummation in our fits is greater at NNLO than at NLO, because
fixed-order calculations have a perturbative instability at small x due to
large logarithms that can be cured by resummation. We explore the
phenomenological implications of PDF sets with small-x resummation for the
longitudinal structure function at HERA, for parton luminosities and LHC
benchmark cross-sections, for ultra-high energy neutrino-nucleus
cross-sections, and for future high-energy lepton-proton colliders such as the
LHeC.Comment: 70 pages, many figures. Discussion on uncertainties due to subleading
logarithmic contributions. Discussion on fits with pseudodata from future
high-energy lepton-proton colliders. Updated references. Version to be
published in EPJ
Circumstellar disks and planets. Science cases for next-generation optical/infrared long-baseline interferometers
We present a review of the interplay between the evolution of circumstellar
disks and the formation of planets, both from the perspective of theoretical
models and dedicated observations. Based on this, we identify and discuss
fundamental questions concerning the formation and evolution of circumstellar
disks and planets which can be addressed in the near future with optical and
infrared long-baseline interferometers. Furthermore, the importance of
complementary observations with long-baseline (sub)millimeter interferometers
and high-sensitivity infrared observatories is outlined.Comment: 83 pages; Accepted for publication in "Astronomy and Astrophysics
Review"; The final publication is available at http://www.springerlink.co
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